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公开(公告)号：US20250059550A1
公开(公告)日：2025-02-20
申请号：US18553006
申请日：2022-03-31
Applicant: Biological E Limited
Inventor： Pavan Reddy REGATTI , Ramesh Venkat MATUR , Narender Dev MANTENA , Mahima DATLA
IPC: C12N15/70 , C07K14/395 , C07K14/605 , C07K14/635
Abstract: The present invention relates to field of protein expression. It provides expression constructs and methods for increased expression of recombinant proteins. More particularly, it provides constructs and methods for enhanced expression of Lira-peptide in a recombinant host cell.
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2.发明授权公开(公告)号：US11547752B2
公开(公告)日：2023-01-10
申请号：US16369933
申请日：2019-03-29
Applicant: BIOLOGICAL E LIMITED
Inventor： Ramesh Venkat Matur , Rajan Sriraman , Deviprasanna Chakka , Satyam Naidu Sureddi , Rajendar Burki , Sreenivasa Rao Ganti , Narender Dev Mantena , Mahima Datla
IPC: A61K39/09 , A61K39/39 , A61K39/385 , A61K9/00 , A61K39/00
Abstract: The present disclosure relates to multivalent pneumococcal vaccine compositions comprising capsular pneumococcal polysaccharide serotypes each individually conjugated to carrier proteins. When conjugated, the combination of the capsular pneumococcal polysaccharide serotype and the carrier protein is referred to herein as a polysaccharide-protein conjugate. The pneumococcal vaccine compositions may further comprise one or more of the following; a pharmaceutically acceptable carrier, a pharmaceutically acceptable diluent, a buffer, a preservative, a stabilizer, an adjuvant, and/or a lyophilization excipient. Methods of making and administering the pneumococcal vaccine compositions described herein are also provided.
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公开(公告)号：US20220390423A1
公开(公告)日：2022-12-08
申请号：US17764351
申请日：2020-09-30
Applicant: Biological E Limited
Inventor： Rajendar BURKI , Ramesh Venkat MATUR , Narender Dev MANTENA , Mahima DATLA
Abstract: The present invention provides a colorimetric based method for quantifying carbohydrates in a given aqueous sample. The method provided by the invention uses 2-Phenoxyethanol as a novel reagent for quantifying carbohydrates in a given sample. The present invention is a rapid, sensitive, simple and direct method for carbohydrate quantification.
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公开(公告)号：US20220143166A1
公开(公告)日：2022-05-12
申请号：US17312820
申请日：2019-10-11
Applicant: Biological E Limited
Inventor： Rajendar BURKI , Rajan SRIRAMAN , Ramesh Venkat MATUR , Narender Dev MANTENA , Mahima DATLA , Balamurali MASILAMANI , Vivek Babu KANDIMALLA , Veerapandu SANGAREDDY
IPC: A61K39/09
Abstract: The present invention relates to multivalent pneumococcal polysaccharide-protein conjugates vaccine composition comprising pneumococcal capsular polysaccharide of one or more Streptococcus pneumoniae serotypes conjugated to one or more carrier proteins.
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公开(公告)号：US11147863B2
公开(公告)日：2021-10-19
申请号：US15772771
申请日：2016-06-21
Applicant: BIOLOGICAL E LIMITED
Inventor： Ramesh Venkat Matur , Nagarajan Thirumeni , Rajendar Burki , Narender Dev Mantena , Mahima Datla
Abstract: The present invention relates to a multivalent Pneumococcal conjugate vaccine (PCV) composition comprising: 1) at least 12 capsular polysaccharides selected from serotypes 1, 3, 4, 5, 6B, 7F, 9N, 9V, 15B, 14, 18C, 19A, 19F, 22F, 23F and 33F of S. pneumoniae activated with CDAP and conjugated to carrier protein selected from CRM197, pneumococcal surface protein A (PspA), pneumococcal adhesin protein (PsaA) or combination thereof and 2) a pharmaceutically acceptable carrier, wherein the composition does not contain capsular polysaccharide from serotype 6A.
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Patent Agency Ranking
公开(公告)号：US20210189019A1
公开(公告)日：2021-06-24
申请号：US16771098
申请日：2018-12-11
Applicant: Biological E Limited
IPC: C08B37/00
Abstract: The present invention provides an improved process for the preparation of Enoxaparin sodium. The process is simple, commercially viable and industrially advantageous.
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公开(公告)号：US20210040239A1
公开(公告)日：2021-02-11
申请号：US16968201
申请日：2019-02-14
Applicant: Biological E Limited
Inventor： Vamsee Krishna Chintakunta , Manohar Sarma Vedula , Narender Dev Mantena , Rajasekhar Kadaboina
Abstract: The present invention provides an improved process for the preparation of Dalteparin sodium. The process is simple, commercially viable and industrially advantageous.
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8.发明申请公开(公告)号：US20180155453A1
公开(公告)日：2018-06-07
申请号：US15568558
申请日：2016-04-25
Applicant: BIOLOGICAL E LIMITED
Inventor： Ramesh Venkat Matur , Vivek Babu Kandimalla , Narender Dev Mantena , Mahima Datla , Muthyala Venkateswara Reddy , Kantam Charan
CPC classification number: C08B37/0003 , A61K39/00 , A61K39/092 , C12P19/04 , Y02A50/484
Abstract: The invention relates to a method for the removal of protein and other impurities from microbial capsular polysaccharides. More particularly, the present invention relates to isolation of microbial capsular polysaccharides in pure form after removal of protein and other impurities.
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9.发明公开公开(公告)号：US20240230545A9
公开(公告)日：2024-07-11
申请号：US18277834
申请日：2022-02-25
Applicant: Biological E Limited
Inventor： Rajendar BURKI , Jaya Sheela PYDIGUMMALA , Sreenivasa Rao GANTI , Siva Prasad KANNURI , Shravan Kumar RENUKUNTLA , Ramesh Venkat MATUR , Narender Dev MANTENA , Mahima DATLA
Abstract: The present invention provides a novel reference standard, comprising of activated-quenched polysaccharide, for quantifying polysaccharide content in a vaccine composition using nephelometry. The invention also provides a method for preparing the activated-quenched polysaccharide, for use as a reference standard. Further, a nephelometry based method for quantifying the polysaccharides in a multivalent conjugate vaccine is also provided. The reference standard of the present invention, comprising of the activated-quenched polysaccharide, is stable and can be used for accurate quantification of polysaccharides through nephelometry.
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10.发明授权公开(公告)号：US11680111B2
公开(公告)日：2023-06-20
申请号：US17035037
申请日：2020-09-28
Applicant: Biological E Limited
Inventor： Ramesh Venkat Matur , Vivek Babu Kandimalla , Narender Dev Mantena , Mahima Datla , Muthyala Venkateswara Reddy , Kantam Charan
CPC classification number: C08B37/0003 , A61K39/092 , C12P19/04 , A61K39/00 , Y02A50/30
Abstract: The invention relates to a method for the removal of protein and other impurities from microbial capsular polysaccharides. More particularly, the present invention relates to isolation of microbial capsular polysaccharides in pure form after removal of protein and other impurities.
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