公开(公告)号：US20240350608A1

公开(公告)日：2024-10-24

申请号：US18634326

申请日：2024-04-12

申请人： Pfizer Inc.

发明人： Bishwa Raj Bhetuwal ,  Kaushik Dutta ,  Jianxin Gu ,  Sunayana Kapil ,  Jin-Hwan Kim ,  Justin Keith Moran ,  Suddham Singh ,  YuYing Yang

IPC分类号： A61K39/09 ,  A61K39/00 ,  A61K39/385 ,  A61K47/64

CPC分类号： A61K39/092 ,  A61K47/646 ,  A61K39/385 ,  A61K2039/55516

摘要： The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates), kits comprising said immunogenic compositions and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.

公开(公告)号：US20240342263A1

公开(公告)日：2024-10-17

申请号：US18757757

申请日：2024-06-28

申请人： Merck Sharp & Dohme LLC

发明人： Jitin Bajaj ,  Michael Albert Winters ,  Emily Wen ,  Jian He

IPC分类号： A61K39/09 ,  A61K39/385 ,  A61K39/00

CPC分类号： A61K39/092 ,  A61K39/385 ,  A61K2039/6037 ,  A61K2039/62

摘要： The present invention provides methods for making polysaccharide-protein conjugates in which polysaccharides, typically from bacteria, are conjugated to a carrier protein by reductive amination under conditions which improve conjugation reaction consistency, increase consumption of protein during conjugation reaction, generate conjugates of higher molecular weight, and/or reduce the levels of free cyanide in the conjugate reaction product. The polysaccharide-protein conjugates obtained using these methods are useful for inclusion in multivalent vaccines.

公开(公告)号：US20240325515A1

公开(公告)日：2024-10-03

申请号：US18621962

申请日：2024-03-29

申请人： Pfizer Inc.

发明人： Kaushik Dutta ,  Caitlyn Gallagher ,  Isis Kanevsky ,  Jin-hwan Kim ,  Justin Keith Moran ,  Suddham Singh ,  Abhishek Ravindra Vartak

IPC分类号： A61K39/09 ,  A61K39/00 ,  A61K47/42 ,  A61P31/04

CPC分类号： A61K39/092 ,  A61K47/42 ,  A61P31/04 ,  A61K2039/55505

摘要： The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates), kits comprising said immunogenic compositions and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.

公开(公告)号：US20240238399A1

公开(公告)日：2024-07-18

申请号：US18419900

申请日：2024-01-23

申请人： SANOFI PASTEUR INC. ,  SK BIOSCIENCE CO., LTD.

发明人： Kyungjun AN ,  Dongsoo HAM ,  Hun KIM ,  Sunghyun KIM ,  Jinhwan SHIN ,  Robert HOPFER ,  Richard D. KENSINGER ,  Moe KYAW ,  Philippe TALAGA

IPC分类号： A61K39/09 ,  A61K9/00 ,  A61K39/00

CPC分类号： A61K39/092 ,  A61K9/0019 ,  A61K2039/6031 ,  A61K2039/70

摘要： Provided are mixed carrier, multivalent pneumococcal conjugate compositions comprising 21 different pneumococcal capsular polysaccharide-protein conjugates, wherein each of the conjugates includes a capsular polysaccharide from a different serotype of Streptococcus pneumoniae conjugated to either tetanus toxoid (TT) or CRM197, wherein the Streptococcus pneumoniae serotypes are selected from 1, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F, where the capsular polysaccharides of two of serotypes 1, 3, and 5 and one or both of serotypes 15B and 22F are conjugated to TT and the remaining capsular polysaccharides are conjugated to CRM197. Also provided are methods of producing the mixed carrier, multivalent pneumococcal conjugate compositions and methods of using the same for prophylaxis against Streptococcus pneumoniae infection or disease in a subject.

公开(公告)号：US20240216491A1

公开(公告)日：2024-07-04

申请号：US18433142

申请日：2024-02-05

申请人： KORANEX CAPITAL

发明人： Tze Chieh SHIAO ,  Serge MOFFETT ,  Serge MIGNANI ,  Rene ROY

IPC分类号： A61K39/00 ,  A61K39/09 ,  A61K39/095 ,  A61K39/145 ,  A61K39/215 ,  A61K39/385 ,  A61K39/39

CPC分类号： A61K39/001169 ,  A61K39/092 ,  A61K39/095 ,  A61K39/145 ,  A61K39/215 ,  A61K39/385 ,  A61K39/39 ,  A61K39/00117 ,  A61K39/001172 ,  A61K2039/575 ,  A61K2039/6031 ,  A61K2039/6037 ,  A61K2039/6056 ,  A61K2039/627 ,  A61K2039/70

摘要： Neoglycoconjugates as immunogens and therapeutic/diagnostic tools are described herein. The neoglycoconjugates are produced by conjugating a carbohydrate antigen intermediate to a free amine group of a carrier material (e.g., carrier protein). The intermediate comprises a linker having a first end and a second end, the first end being conjugated to a carbohydrate antigen via a thio ether bond and the second end comprising a functional group reactable with a free amine group. Following coupling, the carbohydrate antigen becomes covalently bound to the carrier material via an amide, a carbamate, a sulfonamide, a urea, or a thiourea bond, thereby producing the neoglycoconjugate. Applications of the neoglycoconjugates as antigens, immunogens, vaccines, and in diagnostics are also described. Specifically, the use of (neo)glycoconjugates as vaccine candidates and other therapeutic tools against cancers, viruses such as SARS-CoV-2, and other diseases characterized by expression of aberrant glycosylation are also described.

公开(公告)号：US12005108B2

公开(公告)日：2024-06-11

申请号：US17643942

申请日：2021-12-13

申请人： PUKYONG NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION

发明人： Do-Hyung Kim ,  Thanh Luan Nguyen ,  Nam-Eun Kim

IPC分类号： A61K35/744 ,  A23K10/18 ,  A23K50/80 ,  A61K39/02 ,  A61K39/09 ,  C12N1/20 ,  A61K39/106

CPC分类号： A61K39/092 ,  A23K10/18 ,  A23K50/80 ,  A61K35/744 ,  A61K39/025 ,  A61K39/09 ,  C12N1/20 ,  A23V2400/231 ,  A61K2039/106

摘要： The present invention provides a Lactococcus lactis subspecies lactis isolate WFLU-12 with the accession number o KCTC 13180BP, and a use thereof.

公开(公告)号：US20240181043A1

公开(公告)日：2024-06-06

申请号：US18440735

申请日：2024-02-13

申请人： nference, Inc.

发明人： COLIN PAWLOWSKI ,  Venkataramanan Soundararajan ,  Arjun Puranik ,  Murali Aravamudan

IPC分类号： A61K39/215 ,  A61K39/00 ,  A61K39/09 ,  A61K39/116 ,  A61K39/145 ,  A61K39/25 ,  A61K39/29 ,  A61K39/295 ,  A61P31/14 ,  A61P37/04

CPC分类号： A61K39/215 ,  A61K39/092 ,  A61K39/116 ,  A61K39/145 ,  A61K39/25 ,  A61K39/29 ,  A61K39/292 ,  A61K39/295 ,  A61P31/14 ,  A61P37/04 ,  A61K2039/55

摘要： This application relates to methods for assessing patient populations and determining subpopulations vulnerable to viral infection, methods of reducing the risk of infection and/or inducing heterologous immunity to said viral infection.

公开(公告)号：US11998599B2

公开(公告)日：2024-06-04

申请号：US15859251

申请日：2017-12-29

申请人： Vaxcyte, Inc.

发明人： Jeffery Fairman ,  Jon H. Heinrichs ,  Wei Chan

IPC分类号： A61K39/385 ,  A61K39/09 ,  A61K47/64 ,  A61P29/00 ,  A61P31/04 ,  A61P37/00 ,  A61K39/00

CPC分类号： A61K39/385 ,  A61K39/092 ,  A61K47/6415 ,  A61K47/646 ,  A61P29/00 ,  A61P31/04 ,  A61P37/00 ,  A61K2039/575 ,  A61K2039/6037 ,  A61K2039/627

摘要： Methods for the production of immunogenic compositions containing a non-natural amino acid are disclosed. The non-natural amino acid can be a site for attachment of antigens, such as bacterial capsular polysaccharides, to make immunogenic conjugates. Bio-orthogonal attachment chemistry incorporated into the non-natural amino acids allows for more efficient and potent antigen presentation to the immune system, simplified purification, and more well-defined structure of these semi-synthetic immunogens.

公开(公告)号：US11981708B2

公开(公告)日：2024-05-14

申请号：US16945714

申请日：2020-07-31

申请人： CHILDREN'S MEDICAL CENTER CORPORATION

发明人： Richard Malley ,  Yingjie Lu ,  Fan Zhang

IPC分类号： C07K14/31 ,  A61K39/085 ,  A61K39/09 ,  A61K39/385 ,  A61K47/54 ,  A61K47/55 ,  A61K47/61 ,  A61P31/04 ,  A61K39/00

CPC分类号： C07K14/31 ,  A61K39/092 ,  A61K39/385 ,  A61K47/543 ,  A61K47/557 ,  A61K47/61 ,  A61P31/04 ,  A61K2039/55505 ,  A61K2039/6031 ,  A61K2039/6093 ,  A61K2039/625 ,  A61K2039/627 ,  A61K2039/645 ,  A61K2039/70 ,  C07K2319/00 ,  C07K2319/20 ,  Y02A50/30

摘要： The present embodiments provide for an immunogenic multiple antigen presenting system comprising a polymer to which antigens are associated by complementary affinity molecules. For example, the polymer can be a polysaccharide, or antigenic polysaccharide, to which protein or peptide antigens from the same or different pathogens are indirectly linked. The present immunogenic compositions can elicit both humoral and cellular immune responses to one or multiple antigens at the same time.

公开(公告)号：US11969474B2

公开(公告)日：2024-04-30

申请号：US15972758

申请日：2018-05-07

申请人： Wyeth LLC

发明人： A. Krishna Prasad

IPC分类号： A61K47/64 ,  A61K39/00 ,  A61K39/09

CPC分类号： A61K47/646 ,  A61K39/092 ,  A61K2039/55505 ,  A61K2039/6037 ,  A61K2039/70

摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Methods for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 19A polysaccharide are also provided in which the serotype 19A polysaccharide is co-lyophilized with a carrier protein and conjugation is carried out in dimethyl sulfoxide (DMSO) via a reductive amination mechanism.