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1.
公开(公告)号:US20130129771A1
公开(公告)日:2013-05-23
申请号:US13811374
申请日:2011-07-21
申请人: Shai Yarkoni , Nadir Askenasy
发明人: Shai Yarkoni , Nadir Askenasy
IPC分类号: C12N5/0783 , A61K35/14
CPC分类号: C12N5/0637 , A61K35/16 , A61K35/17 , A61K35/26 , A61K39/0008 , A61K39/001 , A61K2039/5158 , C12N5/0006 , C12N2501/48
摘要: An isolated immune regulatory cell having an exogenous cell death-inducing moiety attached to a surface thereof is disclosed herein. Additionally, a molecule comprising a cell death-inducing moiety heterologously attached to an immune regulatory cell-specific binding moiety is disclosed herein. Methods of generating and using same as well as pharmaceutical compositions comprising same are also disclosed.
摘要翻译: 本文公开了具有连接到其表面的外源性细胞死亡诱导部分的分离的免疫调节细胞。 此外,本文公开了包含异源连接到免疫调节细胞特异性结合部分的细胞死亡诱导部分的分子。 还公开了产生和使用它们的方法以及包含其的药物组合物。
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公开(公告)号:US08435786B2
公开(公告)日:2013-05-07
申请号:US12227865
申请日:2007-05-31
申请人: Nadir Askenasy
发明人: Nadir Askenasy
IPC分类号: C12N5/00
CPC分类号: C12N5/0081 , A61K2035/124 , C12N5/0087 , C12N5/0606 , C12N5/0647 , C12N5/0663
摘要: A method of selecting stem cells from heterogeneous population of cells is disclosed. The method comprises contacting the population of cells with an apoptosis inducing agent under conditions which are apoptotic to non-stem cells and non-apoptotic to stem cells, thereby selecting the stem cells from the heterogeneous population of cells. The selected stem cells may then be used for a variety of applications including transportation and differentiation.
摘要翻译: 公开了从异种细胞群体中选择干细胞的方法。 该方法包括在凋亡至非干细胞和非细胞凋亡至干细胞的条件下使细胞群与凋亡诱导剂接触,从而从异源细胞群中选择干细胞。 所选择的干细胞然后可以用于各种应用,包括运输和分化。
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