公开(公告)号：US07344726B2

公开(公告)日：2008-03-18

申请号：US10362494

申请日：2001-08-17

Applicant: Alan Taylor ,  George Andrew Francis Roberts ,  Frances Ann Wood

Inventor： Alan Taylor ,  George Andrew Francis Roberts ,  Frances Ann Wood

IPC: A01N25/00 ,  A01N25/08 ,  A01N59/00 ,  A01N59/16

CPC classification number: A01N59/16 ,  A01N25/10 ,  A01N2300/00

Abstract: In a process for the preparation of an article having a contact biocidal property, there is provided a polymer solution which contains atomic/metallic silver in suspension or complexed with the polymer and/or which contains a silver compound in solution, in suspension or complexed with the polymer. This polymer solution is applied to a substrate by impregnation or surface deposition, thus coating the substrate. Alternatively, it is possible to convert the polymer solution to a fibre, film, powder or foam, effectively forming the article from the polymer solution instead of coating an existing article. In either case, any silver compound present is reduced to atomic/metallic silver, and the resultant article is dried.Chitosan is preferably used as the polymer, although poly(vinyl alcohol) and sodium alginate can also be used. The polymer may be cross-linked at a suitable point in the process to insolubilize it.

Abstract translation: 在制备具有接触杀生物性的制品的方法中，提供了一种聚合物溶液，其包含悬浮液中的原子/金属银或与聚合物络合的和/或在溶液中悬浮或与 聚合物。 通过浸渍或表面沉积将该聚合物溶液施加到基底上，从而涂覆基底。 或者，可以将聚合物溶液转化成纤维，膜，粉末或泡沫，从聚合物溶液中有效地形成制品而不是涂覆现有制品。 在任一种情况下，存在的任何银化合物都被还原为原子/金属银，并将所得制品干燥。 壳聚糖优选用作聚合物，尽管也可以使用聚（乙烯醇）和藻酸钠。 该聚合物可以在该方法的合适点处交联，以使其不溶胀。

公开(公告)号：US07700131B2

公开(公告)日：2010-04-20

申请号：US11183726

申请日：2005-07-18

Applicant: Alan Taylor ,  George Andrew Francis Roberts ,  Frances Ann Wood

Inventor： Alan Taylor ,  George Andrew Francis Roberts ,  Frances Ann Wood

IPC: A01N59/16 ,  A01N25/12 ,  A61K33/38 ,  A61K31/28 ,  A61K9/14

CPC classification number: A01N59/16 ,  A01N43/16 ,  A01N25/10 ,  A01N25/08 ,  A01N2300/00

Abstract: Powders having contact biocidal properties comprise a polysaccharide carrying atomic/metallic silver. The preferred polysaccharide is chitin, although other polysaccharides including chitosan, carboxymethyl celluloses and carrageenans can be used. The chitin may be obtained from deproteinated crustacean shells without demineralisation, thus being admixed with calcium carbonate and other naturally occurring minerals present in the shells, and may be enzyme deacetylated. The powders of the invention can be used as biocidal dusting powders, formulated into pastes, gels, hydrogels, creams, foams and aerosol sprays for pharmaceutical applications, or dissolved to form solutions for coating substrates such as skin, fabrics, glass, leather and paper to give a bactericidal surface. A particular application of such a solution is as a protective, post-wash treatment for workwear in a laundering process. The powders of the invention may be prepared by slurrying a polysaccharide, which is capable of interacting with silver ions and which is in powder form, in a liquid in which the polymer is insoluble, which liquid contains silver ions, filtering off the powder, washing the powder, reducing the silver ions which have interacted with the polysaccharide to atomic/metallic silver, and drying the powder. According to the polysaccharide chosen, the liquid is suitably water or aqueous ethanol. The silver ions may derive from silver nitrate. The reduction of the silver ions which have interacted with the polysaccharide to atomic/metallic silver can be effected photochemically through exposure to light. To hasten the reduction, however, the washed powder is preferably slurried in a solution of an alkali metal halide, irradiated under stirring with natural or artificial light containing an ultraviolet component, and again filtered off and washed, before drying it.

Abstract translation: 具有接触杀生物性质的粉末包含携带原子/金属银的多糖。 优选的多糖是几丁质，尽管可以使用包括壳聚糖，羧甲基纤维素和角叉菜胶的其它多糖。 几丁质可以从去蛋白化甲壳类壳体获得而不脱矿质，因此与壳中存在的碳酸钙和其它天然存在的矿物质混合，并且可以是酶脱乙酰化的。 本发明的粉末可用作生物杀菌粉剂，配制成糊剂，凝胶剂，水凝胶，霜剂，泡沫剂和用于药物应用的泡沫喷雾剂，或溶解形成用于涂覆底物例如皮肤，织物，玻璃，皮革和纸张的溶液 以产生杀菌表面。 这种解决方案的特殊应用是作为洗涤过程中工作服的保护性洗后处理。 本发明的粉末可以通过将能够与银离子相互作用并且呈粉末形式的多糖在聚合物不溶的液体中制浆，该液体含有银离子，过滤掉粉末，洗涤 粉末，将与多糖相互作用的银离子还原成原子/金属银，并干燥粉末。 根据所选择的多糖，液体适宜为水或乙醇水溶液。 银离子可以来自硝酸银。 与多糖与原子/金属银相互作用的银离子的还原可以通过曝光进行光化学反应。 然而，为了加速还原，洗涤的粉末优选在碱性金属卤化物的溶液中浆化，在搅拌下用包含紫外线成分的天然或人造光照射，并再次过滤并洗涤，然后干燥。