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公开(公告)号:US4471149A
公开(公告)日:1984-09-11
申请号:US493407
申请日:1983-05-11
申请人: Kenneth A. Adey , Frank S. Yates , John H. Young
发明人: Kenneth A. Adey , Frank S. Yates , John H. Young
CPC分类号: B01J23/74 , B01J23/76 , B01J23/862 , C07C37/16
摘要: A phenol is ortho-alkylated by reaction with an alkanol in the presence of a catalyst comprising at least 92% w/w, calculated as Fe.sub.2 O.sub.3, of an oxide of iron, and at least one other metal oxide. By way of example, phenol can thus be converted to o-cresol and/or 2,6-xylenol.
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公开(公告)号:US4375544A
公开(公告)日:1983-03-01
申请号:US217325
申请日:1979-06-08
申请人: Otto Meth-Cohn , Brahma Narine
发明人: Otto Meth-Cohn , Brahma Narine
IPC分类号: C07D215/18 , C07D215/20 , C07D215/26 , C07D471/00 , C07D471/04 , C07D495/00 , C07D495/04 , C07D495/14
CPC分类号: C07D471/04 , C07D215/18 , C07D215/20 , C07D215/26 , C07D495/04 , C07D495/14
摘要: Aromatic-.alpha.-halo-{b} fused pyridines are made by reacting an aromatic acetamide, acid halide and amide in particular proportions, with the acid halide always in excess. The process permits the production of compounds having a wide range of substituents, that are new compounds, and that are of value as intermediates in the synthesis of, for instance, pharmaceutical compounds.
摘要翻译: PCT No.PCT / GB79 / 00017 Sec。 371日期:1979年6月8日 102(e)1979年6月8日PCT PCT 1月24日PCT公布。 出版物WO79 / 00540 日期为1979年8月9日。芳族-α-卤代 - {b}稠合吡啶通过使芳族乙酰胺,酰卤和酰胺以特定比例与酰基卤总是过量反应制备。 该方法允许生产具有宽范围取代基的化合物,其是新化合物,并且在合成例如药物化合物中具有价值的中间体。
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公开(公告)号:US4250340A
公开(公告)日:1981-02-10
申请号:US971470
申请日:1978-12-20
申请人: Philip J. McMahon , Frank S. Yates
发明人: Philip J. McMahon , Frank S. Yates
CPC分类号: C07C41/22 , Y02P20/582
摘要: A process for chlorinating m-phenoxytoluene by reaction with sulphuryl chloride in the presence of an initiator, in which the initiator is added not only at the beginning of, but also during, the reaction, and/or in which the initiator is a tert-butyl peralkanoate, and/or in which the reaction solvent is perchloroethylene and/or in which the m-phenoxytoluene and sulphuryl chloride are used in substantially equimolar amounts.
摘要翻译: 在引发剂存在下,通过与磺酰氯反应来氯化间苯氧基甲苯的方法,其中引发剂不仅在反应开始时,而且在反应期间加入和/或其中引发剂是叔 - 和/或其中反应溶剂是全氯乙烯和/或其中间苯氧基甲苯和硫酰氯以基本上等摩尔量使用的那些。
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公开(公告)号:US4386226A
公开(公告)日:1983-05-31
申请号:US308730
申请日:1981-10-05
申请人: Kenneth A. Adey , Frank S. Yates , John H. Young
发明人: Kenneth A. Adey , Frank S. Yates , John H. Young
CPC分类号: B01J23/74 , B01J23/76 , B01J23/862 , C07C37/16
摘要: A phenol is ortho-alkylated by reaction with an alkanol in the presence of a catalyst comprising at least 87% w/w, calculated as Fe.sub.2 O.sub.3, of an oxide of iron, and at least one other metal oxide, in which the other metal is selected from As, Cd, Co, Hg, In, Ni, Pb, lanthanide rare earths, Sc, Sn, Ti and Zr. By way of example, phenol can thus be converted to o-cresol and/or 2,6-xylenol.
摘要翻译: 在催化剂存在下,通过与烷醇反应将苯酚原位烷基化,所述催化剂包含以Fe 2 O 3计的至少87%w / w的铁氧化物和至少一种其它金属氧化物,其中另一种金属是 选自As,Cd,Co,Hg,In,Ni,Pb,镧系稀土,Sc,Sn,Ti和Zr。 举例来说,苯酚因此可以转化为邻甲酚和/或2,6-二甲苯酚。
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