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公开(公告)号：US09005545B2
公开(公告)日：2015-04-14
申请号：US13708236
申请日：2012-12-07
Applicant: Digital Genomics Inc.
Inventor： Jae-Hoon Lee
IPC: G01N33/00 , G01N33/48 , G01N15/06 , G01N27/327 , G01N33/543
CPC classification number: G01N27/3276 , G01N33/54373 , Y10T436/11 , Y10T436/25 , Y10T436/2575
Abstract: The present invention relates to a method for detecting the presence and/or the reaction of a biomolecule by monitoring changes of electrical property accurately according to the biological, biochemical or chemical reaction of the biomolecule, and a biochip provided for this purpose.
Abstract translation: 本发明涉及通过根据生物分子的生物学，生物化学或化学反应以及为此目的提供的生物芯片来监测电性能的变化来检测生物分子的存在和/或反应的方法。
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公开(公告)号：US08354307B2
公开(公告)日：2013-01-15
申请号：US12922934
申请日：2009-01-20
Applicant: Jae-Hoon Lee
Inventor： Jae-Hoon Lee
CPC classification number: G01N27/3276 , G01N33/54373 , Y10T436/11 , Y10T436/25 , Y10T436/2575
Abstract: The present invention relates to a method for detecting the presence and/or the reaction of a biomolecule by monitoring changes of electrical property accurately according to the biological, biochemical or chemical reaction of the biomolecule, and a biochip provided for this purpose. The present invention provides a method for detecting the presence and/or the reaction of a biomolecule in a target sample, wherein the reaction of the target sample is performed under known reaction solution, in which a reference fluid having a high dielectric constant such as water is filled into a reaction chamber before the reaction to measure an impedance value or a capacitance value, after completing the reaction, the reaction solution is removed and said reference fluid having a high dielectric constant is refilled to measure an impedance value or a capacitance value, and then the impedance value or the capacitance value measured before and after the reaction is compared with each other.
Abstract translation: 本发明涉及通过根据生物分子的生物学，生物化学或化学反应以及为此目的提供的生物芯片来监测电性能的变化来检测生物分子的存在和/或反应的方法。 本发明提供了用于检测目标样品中生物分子的存在和/或反应的方法，其中靶样品的反应在已知的反应溶液中进行，其中具有高介电常数的参比流体如水 在反应之前填充到反应室中以测量阻抗值或电容值，在完成反应之后，除去反应溶液，并且重新填充具有高介电常数的所述参考流体以测量阻抗值或电容值， 然后将反应前后测得的阻抗值或电容值进行比较。
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Patent Agency Ranking
公开(公告)号：US20110024309A1
公开(公告)日：2011-02-03
申请号：US12922934
申请日：2009-01-20
Applicant: Jae-Hoon Lee
Inventor： Jae-Hoon Lee
IPC: G01N27/26
CPC classification number: G01N27/3276 , G01N33/54373 , Y10T436/11 , Y10T436/25 , Y10T436/2575
Abstract: The present invention relates to a method for detecting the presence and/or the reaction of a biomolecule by monitoring changes of electrical property accurately according to the biological, biochemical or chemical reaction of the biomolecule, and a biochip provided for this purpose. The present invention provides a method for detecting the presence and/or the reaction of a biomolecule in a target sample, wherein the reaction of the target sample is performed under known reaction solution, in which a reference fluid having a high dielectric constant such as water is filled into a reaction chamber before the reaction to measure an impedance value or a capacitance value, after completing the reaction, the reaction solution is removed and said reference fluid having a high dielectric constant is refilled to measure an impedance value or a capacitance value, and then the impedance value or the capacitance value measured before and after the reaction is compared with each other.
Abstract translation: 本发明涉及通过根据生物分子的生物学，生物化学或化学反应以及为此目的提供的生物芯片来监测电性能的变化来检测生物分子的存在和/或反应的方法。 本发明提供了用于检测目标样品中生物分子的存在和/或反应的方法，其中靶样品的反应在已知的反应溶液中进行，其中具有高介电常数的参比流体如水 在反应之前填充到反应室中以测量阻抗值或电容值，在完成反应之后，除去反应溶液，并且重新填充具有高介电常数的所述参考流体以测量阻抗值或电容值， 然后将反应前后测得的阻抗值或电容值进行比较。
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4.发明申请HIGHLY SENSITIVE BIOSENSOR, BIOCHIP COMPRISING THE SAME AND METHOD FOR MANUFACTURING THE SAME 审中-公开高敏感生物传感器，包含该生物传感器的生物传感器及其制造方法公开(公告)号：US20110017593A1
公开(公告)日：2011-01-27
申请号：US12934093
申请日：2009-01-20
Applicant: Jae-Hoon Lee
Inventor： Jae-Hoon Lee
CPC classification number: G01N33/54393 , G01N27/125
Abstract: The present invention has a feature to form a biocompatible dielectric thin film on the surface of a metal electrode in a biosensor constructing a biochip. When using such a biocompatible dielectric thin film, this non-specific adsorption between a protein such as enzyme and a metal electrode can be prevented. Therefore, the present invention can escape a phenomenon that inhibits the reaction of a biomolecule due to the non-specific adsorption on the surface of a metal electrode. In addition, when the dielectric thin film having a high dielectric constant, as a biocompatible dielectric thin film, is made on the surface of a metal electrode, the sensitivity of an electrical detection according to the reaction of a biomolecule can be improved.
Abstract translation: 本发明的特征在于，在构成生物芯片的生物传感器中，在金属电极的表面上形成生物相容性的电介质薄膜。 当使用这种生物相容的介电薄膜时，可以防止蛋白质如酶和金属电极之间的这种非特异性吸附。 因此，本发明可以避免由于金属电极表面上的非特异性吸附而抑制生物分子的反应的现象。 此外，当在金属电极的表面上形成具有高介电常数的介电薄膜作为生物相容介电薄膜时，可以提高根据生物分子的反应的电检测的灵敏度。
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公开(公告)号：US07871774B2
公开(公告)日：2011-01-18
申请号：US11815198
申请日：2005-01-31
Applicant: Jeong Ho Yoon , Se Nyun Kim , Jong Ho Park , Ja Eun Kim , Young-Hwa Song , Sung Han Kim , Dong Yoon Park
Inventor： Jeong Ho Yoon , Se Nyun Kim , Jong Ho Park , Ja Eun Kim , Young-Hwa Song , Sung Han Kim , Dong Yoon Park
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/158
Abstract: Disclosed is a diagnostic marker specific for lung cancer. Also, the present invention relates to a composition and a kit, comprising an agent measuring the presence of the marker, and a method of diagnosing lung cancer using the composition or kit.
Abstract translation: 公开了肺癌特异性的诊断标记物。 此外，本发明涉及组合物和试剂盒，其包含测量标记物的存在的试剂，以及使用该组合物或试剂盒诊断肺癌的方法。
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6.发明申请公开(公告)号：US20130143775A1
公开(公告)日：2013-06-06
申请号：US13708236
申请日：2012-12-07
Applicant: DIGITAL GENOMICS INC.
Inventor： Jae-Hoon LEE
IPC: G01N27/327
CPC classification number: G01N27/3276 , G01N33/54373 , Y10T436/11 , Y10T436/25 , Y10T436/2575
Abstract: The present invention relates to a method for detecting the presence and/or the reaction of a biomolecule by monitoring changes of electrical property accurately according to the biological, biochemical or chemical reaction of the biomolecule, and a biochip provided for this purpose.
Abstract translation: 本发明涉及通过根据生物分子的生物学，生物化学或化学反应以及为此目的提供的生物芯片来监测电性能的变化来检测生物分子的存在和/或反应的方法。
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公开(公告)号：US20080070793A1
公开(公告)日：2008-03-20
申请号：US11772048
申请日：2007-06-29
Applicant: Jeong Ho Yoon , Se Kim , Young-Hwa Song , Dong Park , Sung Kim , InKyung Shin , Yeo Koh
Inventor： Jeong Ho Yoon , Se Kim , Young-Hwa Song , Dong Park , Sung Kim , InKyung Shin , Yeo Koh
CPC classification number: G01N33/57426 , C12Q1/6886 , C12Q2600/112
Abstract: Disclosed are diagnostic markers specific for acute myeloid leukemia (AML), B-cell lineage acute lymphoblastic leukemia (B-ALL), and T-cell lineage acute lymphoblastic leukemia (T-ALL). Also disclosed are a composition and a kit, comprising an agent detecting the presence of the markers, and a method of diagnosing AML, B-ALL and T-ALL using the same.
Abstract translation: 公开了特异于急性骨髓性白血病（AML），B细胞谱系急性成淋巴细胞白血病（B-ALL）和T细胞谱系急性成淋巴细胞白血病（T-ALL）的诊断标志物。 还公开了组合物和试剂盒，其包含检测标记物的存在的试剂，以及使用其进行AML，B-ALL和T-ALL的诊断方法。
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