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公开(公告)号：US20210355157A1
公开(公告)日：2021-11-18
申请号：US17256777
申请日：2019-07-03
发明人： Ian Edmonds , Edward J. Hessler
摘要： Neuroactive steroid anaesthetic agents, methods for their preparation and compositions comprising the same are disclosed. Also provided are scaled up and/or GMP methods for preparing neuroactive steroids, such as alfaxalone, alfadolone and alfadolone acetate.
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公开(公告)号：US20140066417A1
公开(公告)日：2014-03-06
申请号：US14069751
申请日：2013-11-01
IPC分类号： A61K47/40 , A61K31/57 , A61K31/573 , A61K31/56
CPC分类号： A61K47/40 , A61K31/56 , A61K31/57 , A61K31/573 , A61K47/6951 , B82Y5/00
摘要： The present invention relates generally to the field of drug delivery systems for neuroactive steroid anaesthetic agents. More particularly, anaesthetic and sedative formulations are provided in the form of host/guest preparations comprising one or more neuroactive steroid anaesthetics and a cyclodextrin. Particular cyclodextrins contemplated include sulfoalkyl ether cyclodextrins and modified forms thereof.
摘要翻译： 本发明一般涉及用于神经活性类固醇麻醉剂的药物递送系统领域。 更具体地，以包含一种或多种神经活性类固醇麻醉剂和环糊精的宿主/客体制剂的形式提供麻醉剂和镇静剂制剂。 预期的具体环糊精包括磺基烷基醚环糊精及其修饰形式。
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公开(公告)号：US08975245B2
公开(公告)日：2015-03-10
申请号：US14069751
申请日：2013-11-01
CPC分类号： A61K47/40 , A61K31/56 , A61K31/57 , A61K31/573 , A61K47/6951 , B82Y5/00
摘要： The present invention relates generally to the field of drug delivery systems for neuroactive steroid anaesthetic agents. More particularly, anaesthetic and sedative formulations are provided in the form of host/guest preparations comprising one or more neuroactive steroid anaesthetics and a cyclodextrin. Particular cyclodextrins contemplated include sulfoalkyl ether cyclodextrins and modified forms thereof.
摘要翻译： 本发明一般涉及用于神经活性类固醇麻醉剂的药物递送系统领域。 更具体地，以包含一种或多种神经活性类固醇麻醉剂和环糊精的宿主/客体制剂的形式提供麻醉剂和镇静剂制剂。 预期的具体环糊精包括磺基烷基醚环糊精及其修饰形式。
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公开(公告)号：US11472833B2
公开(公告)日：2022-10-18
申请号：US17256777
申请日：2019-07-03
发明人： Ian Edmonds , Edward J. Hessler
摘要： Neuroactive steroid anaesthetic agents, methods for their preparation and compositions comprising the same are disclosed. Also provided are scaled up and/or GMP methods for preparing neuroactive steroids, such as alfaxalone, alfadolone and alfadolone acetate.
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公开(公告)号：US08697678B2
公开(公告)日：2014-04-15
申请号：US13574201
申请日：2011-01-19
IPC分类号： A61K31/56
CPC分类号： A61K47/40 , A61K31/56 , A61K31/57 , A61K31/573 , A61K47/6951 , B82Y5/00
摘要： The present invention relates generally to the field of drug delivery systems for neuroactive steroid anaesthetic agents. More particularly, anaesthetic and sedative formulations are provided in the form of host/guest preparations comprising one or more neuroactive steroid anaesthetics and a cyclodextrin. Particular cyclodextrins contemplated include sulfoalkyl ether cyclodextrins and modified forms thereof.
摘要翻译： 本发明一般涉及用于神经活性类固醇麻醉剂的药物递送系统领域。 更具体地，以包含一种或多种神经活性类固醇麻醉剂和环糊精的宿主/客体制剂的形式提供麻醉剂和镇静剂制剂。 预期的具体环糊精包括磺基烷基醚环糊精及其修饰形式。
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