公开(公告)号：US06958059B2

公开(公告)日：2005-10-25

申请号：US10035389

申请日：2001-12-28

申请人： Gholam-Reza Zadno-Azizi

发明人： Gholam-Reza Zadno-Azizi

IPC分类号： A61B17/12 ,  A61B17/22 ,  A61B18/24 ,  A61F2/01 ,  A61F2/958 ,  A61M1/00 ,  A61M25/00 ,  A61M29/02 ,  A61M31/00 ,  A61M37/00

CPC分类号： A61M25/10184 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/22 ,  A61B18/245 ,  A61B2017/22048 ,  A61B2017/22067 ,  A61B2017/22084 ,  A61B2217/005 ,  A61F2/01 ,  A61F2230/0006 ,  A61M25/0009 ,  A61M25/0026 ,  A61M25/0051 ,  A61M25/0052 ,  A61M25/0053 ,  A61M25/0054 ,  A61M25/0068 ,  A61M25/007 ,  A61M25/0071 ,  A61M25/0075 ,  A61M25/09 ,  A61M25/09033 ,  A61M25/10 ,  A61M25/1011 ,  A61M25/10182 ,  A61M25/104 ,  A61M2025/0018 ,  A61M2025/09008 ,  A61M2025/09116 ,  A61M2025/09125 ,  A61M2025/09141 ,  A61M2025/09175 ,  A61M2025/09183 ,  A61M2025/1015 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1079 ,  A61M2025/1081 ,  A61M2025/109 ,  A61M2025/1093 ,  A61M2210/0693

摘要： A method for delivering a drug to the site of an intravascular occlusion. A guidewire having a balloon at one end is advanced across the occlusion using a guide catheter, and the balloon is inflated distal to the occlusion to occlude the blood vessel. An aspiration catheter is then inserted into the vessel with its tip less than about 5 mm from the surface of the balloon, and a drug is delivered which flows distal to proximal to treat the occlusion.

摘要翻译： 将药物递送至血管内闭塞部位的方法。 在一端具有气球的导丝使用引导导管穿过闭塞，并且气囊在封闭物的远侧被充气以封闭血管。 然后将吸入导管插入到血管中，其末端距球囊表面小于约5mm，并且输送药物以远端近端流动以治疗闭塞。

公开(公告)号：US20050027236A1

公开(公告)日：2005-02-03

申请号：US10629824

申请日：2003-07-30

申请人： Nareak Douk

发明人： Nareak Douk

IPC分类号： A61M1/00 ,  A61M3/02

CPC分类号： A61M1/008 ,  A61M2025/0004 ,  A61M2025/0175 ,  A61M2025/1068

摘要： An aspiration catheter includes an aspiration shaft and a telescoping outer sheath which can be passed over a guidewire. The sheath includes “nesting” proximal and distal tubes. The distal tube slides within a proximal tube lumen, and the aspiration shaft slides within a distal tube lumen. The catheter can be placed in an expanded position by pushing the aspiration shaft, thereby causing the distal tube to be moved distally. The catheter can be retracted by pulling the aspiration shaft proximally so that a distal segment of the aspiration shaft is drawn into the distal tube lumen and the distal tube is drawn into the proximal tube lumen. Alternatively, a middle tube is slidingly disposed over the aspiration shaft between the proximal and distal tubes. In this embodiment, the middle tube nests within the proximal tube lumen and the distal tube nests within a middle tube lumen.

摘要翻译： 抽吸导管包括可以穿过导​​丝的抽吸轴和可伸缩的外护套。 护套包括“嵌套”近端和远端管。 远端管在近端管腔内滑动，并且抽吸轴在远端管腔内滑动。 导管可以通过推动抽吸轴而放置在扩张位置，从而使远端管能够向远侧移动。 可以通过将吸引轴向近侧拉动使得导管缩回，使得吸引轴的远侧部分被拉入远端管腔并且远端管被拉入近端管腔。 或者，中间管滑动地设置在近端管和远端管之间的抽吸轴之上。 在该实施例中，中管嵌套在近端管腔内，而远端管嵌套在中管腔内。

公开(公告)号：US20040215323A1

公开(公告)日：2004-10-28

申请号：US10423147

申请日：2003-04-24

申请人： Medtronic AVE, Inc.

发明人： Mark L. Stiger

IPC分类号： A61F002/06

CPC分类号： A61B17/0293 ,  A61B17/00234 ,  A61B17/0218 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61F2/2493 ,  A61F2/90

摘要： A structure and method for deploying an eyelet in a membrane, where the eyelet includes: a waist section; a first anchor section coupled to and flared from the waist section; and a second anchor section coupled to and flared from the waist section. The eyelet is deployed such that the waist section is located within a membrane opening of the membrane thus keeping the membrane opening open. Further, the membrane is sandwiched between the first and second anchor sections thus anchoring the eyelet to the membrane.

摘要翻译： 用于在膜中部署孔眼的结构和方法，其中孔眼包括：腰部; 耦合到腰部并从腰部部分扩张的第一锚固部分; 以及耦合到腰部并从腰部部分扩张的第二锚固部分。 孔眼部署成使得腰部位于膜的膜开口内，从而保持膜开口敞开。 此外，膜被夹在第一和第二锚定部分之间，从而将孔眼锚定在膜上。

公开(公告)号：US20040215165A1

公开(公告)日：2004-10-28

申请号：US10421906

申请日：2003-04-24

申请人： Medtronic AVE, Inc.

发明人： Noel Coyle ,  Patrick Duane

IPC分类号： A61M025/00

CPC分类号： A61M25/0169 ,  A61M25/0172 ,  A61M25/104 ,  A61M2025/0177 ,  A61M2025/0183 ,  A61M2025/0186

摘要： A balloon catheter includes a full-length inflation shaft and a guidewire shaft for fast catheter and guidewire exchange. The proximal portions of the inflation shaft and the guidewire shaft are detached from one another. The detached proximal shaft portions transition within a conversion portion of the catheter shaft and become coaxial within a distal portion of the catheter shaft. The proximal portion of the guidewire shaft may contain a continuous, longitudinally extending slot that acts as a guide member or guidewire track. Alternatively, the proximal portion of the guidewire shaft maybe removable from the catheter at a conversion joint via a snap-fit connection. Both embodiments allow for catheter exchange without removing the guidewire from a body lumen, or allow guidewire exchange without removing the catheter from the body lumen.

摘要翻译： 气囊导管包括全长膨胀轴和用于快速导管和导丝交换的导丝轴。 充气轴和导丝轴的近端部彼此分离。 分离的近侧轴部分在导管轴的转换部分内转变并且在导管轴的远侧部分内变得同轴。 导丝轴的近端部分可以包含用作引导构件或导丝轨迹的连续的纵向延伸的槽。 或者，导丝轴的近端部分可以通过卡扣配合连接在转换接头处从导管移除。 两个实施例允许导管交换而不从体腔移除导丝，或允许导丝交换而不从体腔移除导管。

公开(公告)号：US6110144A

公开(公告)日：2000-08-29

申请号：US359805

申请日：1999-07-26

申请人： Richard T. Choh ,  John R. Fagan ,  Stephen J. Forcucci

发明人： Richard T. Choh ,  John R. Fagan ,  Stephen J. Forcucci

IPC分类号： A61F2/958 ,  A61M29/00

CPC分类号： A61M25/10184 ,  A61M25/1018 ,  A61M2025/0001 ,  A61M2025/105

摘要： The invention relates to an apparatus and method for limiting the pressure of inflation fluid injected into a drug delivery catheter balloon, while permitting continuous and uninterrupted flow of such fluid to the balloon. The apparatus includes an elongated hollow housing having a fluid entrance, a fluid exit and a bore extending therebetween which forms an interconnecting chamber and passageway. A piston and piston shaft assembly is disposed inside the housing and is longitudinally movable within the chamber. The piston and piston shaft assembly is biased against the fluid pressure of the fluid entering the housing by a spring. The piston shaft has a distal end which extends toward the passageway inlet. As the incoming fluid pressure increases and approaches the predetermined maximum pressure level of the apparatus, the piston shaft distal end moves within the chamber against the biasing force of the spring toward a position adjacent the passageway inlet. When the incoming fluid pressure reaches and exceeds the predetermined maximum pressure level, the piston shaft distal end enters and extends into the passageway, thereby forming an annulus within the passageway. The annulus functions to restrict the flow rate and limit the pressure of the fluid exiting the housing and entering the catheter balloon.

摘要翻译： 本发明涉及一种用于限制注射到药物递送导管球囊中的充气流体的压力的装置和方法，同时允许这种流体连续且不间断地流入气囊。 该装置包括细长的中空壳体，其具有流体入口，流体出口和在其间延伸的孔，其形成互连室和通道。 活塞和活塞轴组件设置在壳体内部并且可在腔室内纵向移动。 活塞和活塞轴组件被抵抗通过弹簧进入壳体的流体的流体压力而偏置。 活塞轴具有朝向通道入口延伸的远端。 当进入的流体压力增加并且接近装置的预定最大压力水平时，活塞轴远端抵抗弹簧的偏置力抵抗通道入口附近的位置移动。 当进入的流体压力达到并超过预定的最大压力水平时，活塞轴远端进入并延伸到通道中，从而在通道内形成环形空间。 环的作用是限制流速并限制离开壳体并进入导管气囊的流体的压力。

公开(公告)号：US5993416A

公开(公告)日：1999-11-30

申请号：US7427

申请日：1998-01-15

申请人： Richard T. Choh ,  John R. Fagan ,  Stephen J. Forcucci

发明人： Richard T. Choh ,  John R. Fagan ,  Stephen J. Forcucci

IPC分类号： A61F2/958 ,  A61M29/00

CPC分类号： A61M25/10184 ,  A61M25/1018 ,  A61M2025/0001 ,  A61M2025/105

摘要： The invention relates to an apparatus and method for limiting the pressure of inflation fluid injected into a drug delivery catheter balloon, while permitting continuous and uninterrupted flow of such fluid to the balloon. The apparatus includes an elongated hollow housing having a fluid entrance, a fluid exit and a bore extending therebetween which forms an interconnecting chamber and passageway. A piston and piston shaft assembly is disposed inside the housing and is longitudinally movable within the chamber. The piston and piston shaft assembly is biased against the fluid pressure of the fluid entering the housing by a spring. The piston shaft has a distal end which extends toward the passageway inlet. As the incoming fluid pressure increases and approaches the predetermined maximum pressure level of the apparatus, the piston shaft distal end moves within the chamber against the biasing force of the spring toward a position adjacent the passageway inlet. When the incoming fluid pressure reaches and exceeds the predetermined maximum pressure level, the piston shaft distal end enters and extends into the passageway, thereby forming an annulus within the passageway. The annulus functions to restrict the flow rate and limit the pressure of the fluid exiting the housing and entering the catheter balloon.

公开(公告)号：US20050043786A1

公开(公告)日：2005-02-24

申请号：US10643649

申请日：2003-08-18

申请人： Jack Chu ,  Scott Doig ,  David Brin

发明人： Jack Chu ,  Scott Doig ,  David Brin

IPC分类号： A61F2/00 ,  A61F2/06 ,  A61F2/88

CPC分类号： A61F2/88 ,  A61F2250/0067

摘要： Methods and apparatus for aiding aneurysm repair are provided. Such apparatus is constructed to support or bolster the aneurysmal site initially, while contracting if the aneurysmal site shrinks or contracts. The apparatus also supplies a pharmaceutical agent to aid in healing the surrounding aneurysmal tissue. The apparatus may comprise a drug eluting polymer or may have a passive coating which can be selectively deployed by adding an activation agent after deployment. The device can be used alone or in conjunction with a AAA stent graft that isolates the aneurysmal sac from the vascular system.

摘要翻译： 提供了辅助动脉瘤修复的方法和装置。 这种装置被构造成最初支撑或支撑动脉瘤部位，同时如果动脉瘤部位缩小或收缩则承包。 该装置还提供药剂以帮助愈合周围的动脉瘤组织。 该装置可以包括药物洗脱聚合物或可以具有被动涂层，其可以在部署之后通过添加活化剂来选择性地部署。 该装置可以单独使用或与用于将动脉瘤囊与血管系统隔离的AAA支架移植物结合使用。

公开(公告)号：US06849068B1

公开(公告)日：2005-02-01

申请号：US09454522

申请日：1999-12-06

申请人： Celso J. Bagaoisan ,  Hung V. Ha ,  Mukund R. Patel ,  Sivette Lam

发明人： Celso J. Bagaoisan ,  Hung V. Ha ,  Mukund R. Patel ,  Sivette Lam

IPC分类号： A61F2/958 ,  A61M25/00

CPC分类号： A61M25/1011 ,  A61M2025/1015 ,  A61M2025/1052 ,  A61M2025/109 ,  A61M2025/1093

摘要： Aspiration catheters suitable for use in the treatment of an occlusion in a blood vessel are disclosed. These catheters are especially useful in the removal of occlusions from saphenous vein grafts, the coronary and carotid arteries, arteries above the aortic arch and even smaller vessels. The catheters of the present invention are provided in either over-the-wire or in single operator form. Radiopaque markers are preferably incorporated into distal ends of the catheters to facilitate their positioning within the body. The catheters are provided with varying flexibility along the length of the shaft, such that they are soft and flexible enough to be navigated through the vasculature of a patient without causing damage, but are stiff enough to sustain the axial push required to position the catheter properly and to sustain the aspiration pressures.

摘要翻译： 公开了适合用于治疗血管闭塞的吸引导管。 这些导管特别适用于从隐静脉移植物，冠状动脉和颈动脉，主动脉弓上方的动脉以及更小的血管中去除闭塞。 本发明的导管以线上或单个操作者形式提供。 不透射线标记物优选并入导管的远端，以便于它们在体内的定位。 导管沿着轴的长度设置有不同的柔性，使得它们柔软且足够灵活，以便穿过患者的脉管系统而不造成损伤，但足够坚硬以维持正确定位导管所需的轴向推动 并维持吸引压力。

公开(公告)号：US20040215327A1

公开(公告)日：2004-10-28

申请号：US10423297

申请日：2003-04-25

申请人： Medtronic AVE, Inc.

发明人： Scott Doig ,  James Machek

IPC分类号： A61F002/06

CPC分类号： A61F2/90 ,  A61F2/07 ,  A61F2/852 ,  A61F2/856 ,  A61F2002/061 ,  A61F2002/075 ,  A61F2002/826 ,  A61F2220/0033 ,  A61F2250/0008 ,  A61F2250/006 ,  A61F2250/0065

摘要： Universal modular stented graft assemblies are assembled, on site, and often in a patient's parent artery, from at least two components; a first component and a second component. The first and second components each include a window, or fenestration. The second component couples with the first component by fitting at least partially in the first component to form the universal modular stent graft assembly with an adjustable collateral opening. As the first and second components are assembled, the first and second components are adjusted relative to each other so that the first and second component windows overlap to form a collateral opening whose size is selectable, depending on the overlap, with the desired position and dimensions in the universal modular stent graft assembly.

摘要翻译： 通用模块化支架移植组件在现场并经常在患者的母体动脉中从至少两个组件组装; 第一组件和第二组件。 第一和第二组件各自包括窗口或开窗。 第二部件通过至少部分地配合在第一部件中而与第一部件联接以形成具有可调节的侧支开口的通用模块化支架移植物组件。 当组装第一和第二部件时，第一和第二部件相对于彼此进行调节，使得第一和第二部件窗口重叠以形成侧面开口，其尺寸可根据重叠与期望的位置和尺寸可选择 在通用模块化支架移植组件中。

公开(公告)号：US20040215229A1

公开(公告)日：2004-10-28

申请号：US10421290

申请日：2003-04-22

申请人： Medtronic AVE, Inc.

发明人： James Coyle

IPC分类号： A61F002/02 ,  A61M029/00

CPC分类号： A61F2/013 ,  A61F2/95 ,  A61F2/958 ,  A61F2002/9528 ,  A61F2002/9583 ,  A61F2230/0006

摘要： A filter is deployed adjacent an occlusion in a vessel. A device including a stent and a sheath is advanced to the occlusion, the sheath is retracted to deploy the stent, and the stent is post dilated by a balloon of the device. The sheath is advanced through the deployed stent and over the balloon and over the filter. Since the balloon and the filter are enclosed within the sheath, any possibility of the balloon and/or the filter catching on the stent during retraction is eliminated.

摘要翻译： 过滤器被部署在容器中的闭塞附近。 包括支架和护套的装置前进到闭塞，护套被缩回以展开支架，并且支架被装置的气囊后扩张。 护套通过部署的支架前进穿过气囊和过滤器。 由于气囊和过滤器被包封在护套内，消除了在收缩期间球囊和/或过滤器在支架上捕获的任何可能性。