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公开(公告)号：US07955677B2
公开(公告)日：2011-06-07
申请号：US11296604
申请日：2005-12-07
IPC分类号： B32B37/00
CPC分类号： A61K9/703 , A61F2013/0296 , Y10T428/14 , Y10T428/149 , Y10T428/1495 , Y10T428/15 , Y10T428/24273 , Y10T428/24298 , Y10T428/24314 , Y10T428/24322 , Y10T428/24331
摘要： Assemblies for the adhesive attachment to the skin or mucosa of a host are disclosed. The assembly or transdermal patch includes an outer backing layer, a first layer of adhesive on the inner surface of the outer backing layer, an inner backing layer, and an intermediate release liner between the first layer of adhesive and the inner backing layer. The intermediate release liner includes a releasable surface on both its inner and outer surfaces.
摘要翻译： 公开了用于粘合剂附着到宿主皮肤或粘膜的组件。 组装体或透皮贴片包括外背衬层，在外背衬层的内表面上的第一粘合剂层，内背衬层，以及在第一粘合剂层和内背衬层之间的中间剥离衬垫。 中间剥离衬垫包括其内表面和外表面上的可释放表面。
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公开(公告)号：US20060188558A1
公开(公告)日：2006-08-24
申请号：US11062084
申请日：2005-02-18
申请人： Kristin Jackson , Kenneth Miller , Pavan Bhat
发明人： Kristin Jackson , Kenneth Miller , Pavan Bhat
IPC分类号： A61K9/70
CPC分类号： A61K9/7061 , A61F13/0276 , A61F13/0283 , A61F13/0289 , A61F2013/0296 , A61K9/7053 , A61K9/7092 , A61K31/00 , A61K31/137 , A61K31/565 , A61K47/10 , A61K47/12
摘要： Transdermal delivery systems are disclosed including a backing layer, a polymer membrane within the backing layer, an adhesive layer for attaching the delivery system to the patient's skin or mucosa, and a releasable layer covering the adhesive layer prior to use, the polymer membrane impregnated with sufficient fluid medium to alter the rate of transmission of an active agent through the polymer membrane, with the amount of fluid medium being greater than the amount retained by the fluid membrane upon drying.
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公开(公告)号：US09226902B2
公开(公告)日：2016-01-05
申请号：US12475390
申请日：2009-05-29
申请人： Jiashang Tang
发明人： Jiashang Tang
CPC分类号： A61K9/7061 , A61K9/7069 , A61K9/7092 , Y10T156/10
摘要： A solid dispersion transdermal drug delivery system comprising a therapeutic agent in a stable amorphous form and a combination polymeric stabilizing and dispersing agent having a hydrogen bond-forming functional group, and a method of manufacturing these systems is provided. The weight ratio of the combination polymeric stabilizing and dispersing agent to the therapeutic agent is also disclosed.
摘要翻译： 提供了包含稳定无定形形式的治疗剂和具有形成氢键的官能团的聚合稳定分散剂的固体分散透皮药物递送系统及其制造方法。 还公开了组合聚合物稳定剂和分散剂与治疗剂的重量比。
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公开(公告)号：US20150246006A1
公开(公告)日：2015-09-03
申请号：US14700316
申请日：2015-04-30
IPC分类号： A61K9/70 , A61K31/137 , A61F13/02 , A61K31/565
CPC分类号： A61K9/7061 , A61F13/0276 , A61F13/0283 , A61F13/0289 , A61F2013/0296 , A61K9/7053 , A61K9/7092 , A61K31/00 , A61K31/137 , A61K31/565 , A61K47/10 , A61K47/12
摘要： Transdermal delivery systems are disclosed including a backing layer, a polymer membrane within the backing layer, an adhesive layer for attaching the delivery system to the patient's skin or mucosa, and a releasable layer covering the adhesive layer prior to use, the polymer membrane impregnated with sufficient fluid medium to alter the rate of transmission of an active agent through the polymer membrane, with the amount of fluid medium being greater than the amount retained by the fluid membrane upon drying.
摘要翻译： 公开了透皮递送系统，其包括背衬层，背衬层内的聚合物膜，用于将递送系统附着到患者皮肤或粘膜的粘合剂层，以及在使用之前覆盖粘合剂层的可释放层，所述聚合物膜浸渍 足够的流体介质来改变活性剂通过聚合物膜的传播速率，流体介质的量大于干燥时由流体膜保留的量。
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公开(公告)号：US09017301B2
公开(公告)日：2015-04-28
申请号：US11899136
申请日：2007-09-04
申请人： Jiansheng Tang
发明人： Jiansheng Tang
CPC分类号： A61M37/00 , A61F13/00063 , A61F13/02 , A61F13/0206 , A61F13/0226 , A61F13/0253 , A61F13/0259 , A61F13/0276 , A61K9/703 , A61K9/7053 , A61K9/7084 , A61K9/7092
摘要： The present invention refers to a transdermal delivery device comprising a backing layer, at least one adhesive layer, and a release liner coated with a UV-cured highly crosslinked silicone. The present invention also refers to a method of preparing a transdermal delivery device comprising a backing layer, at least one adhesive layer, and a release liner coated with a UV-cured silicone.
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6.发明授权公开(公告)号：US08846093B2
公开(公告)日：2014-09-30
申请号：US13100581
申请日：2011-05-04
申请人： Sharad K. Govil , Ludwig J. Weimann
发明人： Sharad K. Govil , Ludwig J. Weimann
IPC分类号： A61K9/14 , A61K9/70 , A61K31/137 , A61K31/138 , A61K31/4402
CPC分类号： A61K9/7061 , A61K31/137 , A61K31/138 , A61K31/4402 , A61K45/06 , A61K47/32
摘要： Transdermal drug delivery patches and methods of their production are described. The patches can be made such that the accommodate highly plasticizing drugs such as selegiline and/or the use of protonated forms of various drugs.
摘要翻译： 描述了透皮药物递送贴剂及其生产方法。 可以制备贴片使得容纳高度增塑药物如司来吉兰和/或使用质子化形式的各种药物。
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公开(公告)号：US20110123613A1
公开(公告)日：2011-05-26
申请号：US12977713
申请日：2010-12-23
申请人： Pavan Bhat , Sarat C. Chattaraj , Andrew A. Shaw
发明人： Pavan Bhat , Sarat C. Chattaraj , Andrew A. Shaw
IPC分类号： A61K9/16 , A61K31/138 , A61K9/54 , A61K9/24
CPC分类号： A61K31/138 , A61K9/501 , A61K9/5015 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K9/5073 , A61K9/5084
摘要： Provided are pharmaceutical formulations comprising sustained release particles each having an inner core bead comprising an active pharmaceutical ingredient an intermediate coating substantially surrounding the inner core bead, and an outer coating substantially surrounding the intermediate coating comprising a pH independent polymer. Also provided is a pharmaceutical formulation comprising two bead populations wherein each of the first and second bead populations have a different drug release profile. Also provided is a method of preparing an extended release dosage composition comprising one or more bead populations.
摘要翻译： 提供了包含持续释放颗粒的药物制剂，其各自具有包含活性药物成分的内芯珠，基本上围绕内芯珠的中间涂层，以及基本上围绕包含pH独立聚合物的中间涂层的外涂层。 还提供了包含两个珠粒的药物制剂，其中第一和第二珠粒中的每一个具有不同的药物释放曲线。 还提供了制备包含一个或多个珠粒的延长释放剂量组合物的方法。
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公开(公告)号：US20090299304A1
公开(公告)日：2009-12-03
申请号：US12475390
申请日：2009-05-29
申请人： Jiashang Tang
发明人： Jiashang Tang
CPC分类号： A61K9/7061 , A61K9/7069 , A61K9/7092 , Y10T156/10
摘要： A solid dispersion transdermal drug delivery system comprising a therapeutic agent in a stable amorphous form and a combination polymeric stabilizing and dispersing agent having a hydrogen bond-forming functional group, and a method of manufacturing these systems is provided. The weight ratio of the combination polymeric stabilizing and dispersing agent to the therapeutic agent is also disclosed.
摘要翻译： 提供了包含稳定无定形形式的治疗剂和具有形成氢键的官能团的聚合稳定分散剂的固体分散透皮药物递送系统及其制造方法。 还公开了组合聚合物稳定剂和分散剂与治疗剂的重量比。
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9.发明申请Amorphous drug transdermal systems, manufacturing methods, and stabilization 审中-公开无定形药物透皮系统，制造方法和稳定性公开(公告)号：US20080226698A1
公开(公告)日：2008-09-18
申请号：US11725159
申请日：2007-03-16
IPC分类号： A61K31/215 , A61F13/02 , A61K31/4353 , A61K31/4355 , A61K9/70 , A61P43/00
CPC分类号： A61K9/7053 , A61K9/7069
摘要： The present invention refers to a transdermal delivery device comprising a backing layer, an adhesive matrix layer comprising a supersaturated concentration of an active agent substantially in amorphous form within the adhesive matrix, and a release liner. The present invention also refers to a method of preparing an adhesive matrix containing at least one supersaturated active agent substantially in amorphous form. Further, the present invention refers to a method to stabilize and a method to reestablish the meta-stable amorphous-drug transdermal system during its manufacturing, storing, shipping and handling process.
摘要翻译： 本发明涉及一种透皮递送装置，其包括背衬层，包含过饱和浓度的基本上为无定形形式的粘合剂基质中的活性剂的粘合剂基质层和释放衬垫。 本发明还涉及制备含有至少一种基本上为无定形形式的过饱和活性剂的粘合剂基质的方法。 此外，本发明涉及一种稳定化方法以及在其制造，储存，运输和处理过程中重新建立间 - 稳定非晶药物透皮系统的方法。
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公开(公告)号：US20070125483A1
公开(公告)日：2007-06-07
申请号：US11296604
申请日：2005-12-07
申请人： Brad Barnett , Martin Fletcher , Kenneth Miller
发明人： Brad Barnett , Martin Fletcher , Kenneth Miller
IPC分类号： B32B37/00
CPC分类号： A61K9/703 , A61F2013/0296 , Y10T428/14 , Y10T428/149 , Y10T428/1495 , Y10T428/15 , Y10T428/24273 , Y10T428/24298 , Y10T428/24314 , Y10T428/24322 , Y10T428/24331
摘要： Assemblies for the adhesive attachment to the skin or mucosa of a host are disclosed. The assembly or transdermal patch includes an outer backing layer, a first layer of adhesive on the inner surface of the outer backing layer, an inner backing layer, and an intermediate release liner between the first layer of adhesive and the inner backing layer. The intermediate release liner includes a releasable surface on both its inner and outer surfaces.
摘要翻译： 公开了用于粘合剂附着到宿主皮肤或粘膜的组件。 组装体或透皮贴片包括外背衬层，在外背衬层的内表面上的第一粘合剂层，内背衬层，以及在第一粘合剂层和内背衬层之间的中间剥离衬垫。 中间剥离衬垫包括其内表面和外表面上的可释放表面。
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