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    Transdermal patch incorporating a polymer film incorporated with an active agent
    3.
    发明授权
    Transdermal patch incorporating a polymer film incorporated with an active agent 失效
    包含掺入活性剂的聚合物膜的透皮贴剂

    公开(公告)号：US6010715A

    公开(公告)日：2000-01-04

    申请号：US954861

    申请日：1997-10-21

    申请人： John J. Wick ,  Ludwig J. Weimann ,  Wayne C. Pollock

    发明人： John J. Wick ,  Ludwig J. Weimann ,  Wayne C. Pollock

    IPC分类号： A61K9/70 ,  A61F13/02

    CPC分类号： A61K9/7084

    摘要： Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a backing layer and a monolithic carrier layer formed from a melt blend of an active ingredient with a thermoplastic matrix polymer without first dissolving or suspending the polymer or active ingredient in a solvent therefor, so that the carrier layer is substantially free of residual solvent, wherein the thermoplastic matrix polymer has a melt temperature between about 170.degree. C. and about 200.degree. C. and is selected from polyether block amides, ethylene methacrylic acid copolymers, ethylene acrylic acid copolymers, copolymers of polyether prepolymers with polybutylene terephthalate, copolymers of polyether prepolymers with polyisobutylene terephthalate and polyether polyurethanes, the active ingredient is heat stable at the melt temperature of the matrix polymer and is selected from active agents, active agent enhancers and mixtures thereof, and the laminate is provided with means for affixing the laminate to the skin or mucosa of the host so that the active ingredient is continuously released from the carrier layer thereto. Methods for assembling the device are also disclosed.

    摘要翻译： 公开了用于将活性剂受控释放到宿主皮肤或粘膜的装置，哪些装置是背衬层和由活性成分与热塑性基质聚合物的熔体共混物形成的整体载体层的叠层体，而没有首先溶解 或将聚合物或活性成分悬浮在其溶剂中，使得载体层基本上不含残留溶剂，其中热塑性基质聚合物的熔体温度在约170℃至约200℃之间，并且选自聚醚 嵌段酰胺，乙烯甲基丙烯酸共聚物，乙烯丙烯酸共聚物，聚醚预聚物与聚对苯二甲酸丁二醇酯的共聚物，聚醚预聚物与聚异丁烯对苯二甲酸酯和聚醚聚氨酯的共聚物，活性成分在基体聚合物的熔融温度下是热稳定的， 活性剂，活性剂增强剂及其混合物，以及Lami 本发明提供了用于将层压材料固定到主体的皮肤或粘膜上的装置，使得活性成分从载体层连续释放。 还公开了组装装置的方法。

    Process of assembling a transdermal patch incorporating a polymer film incorporated with an active agent
    4.
    发明授权
    Process of assembling a transdermal patch incorporating a polymer film incorporated with an active agent 失效
    组装含有掺入活性剂的聚合物膜的透皮贴剂的方法

    公开(公告)号：US5679373A

    公开(公告)日：1997-10-21

    申请号：US477042

    申请日：1995-06-07

    申请人： John Wick ,  Ludwig J. Weimann ,  Wayne C. Pollock

    发明人： John Wick ,  Ludwig J. Weimann ,  Wayne C. Pollock

    IPC分类号： A61M37/00 ,  A61K9/70 ,  A61F13/02

    CPC分类号： A61K9/703 ,  A61K9/7084

    摘要： Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a backing layer, a monolithic carrier layer of an active ingredient selected from active agent, active agent enhancers and mixtures thereof, melt-blended with a thermoplastic matrix polymer capable of controllably releasing the active ingredient, wherein the active ingredient is heat stable at the melt temperature of the matrix polymer, together with means for affixing the laminate to the skin or mucosa of the host so that the active ingredient is continuously released from the carrier layer thereto. Methods for assembling the device are also disclosed, in which a thermoplastic matrix polymer capable of controllably releasing an active ingredient is melt-blended with an active ingredient that is heat stable at the melt temperature of the matrix polymer, so that a melt-blend of the active ingredient and the thermoplastic matrix polymer is formed, which melt-blend is formed into a monolithic carrier layer, and the carrier layer is then combined with a backing layer and means for affixing the laminate to the skin or mucosa of the host so that the active ingredient is released from the carrier layer thereto.

    摘要翻译： 公开了将活性剂受控释放到宿主皮肤或粘膜的装置，哪些装置是背衬层的叠层，选自活性成分的活性成分的整体载体层，活性剂增强剂及其混合物，熔体 与能够可控地释放活性成分的热塑性基质聚合物共混，其中活性成分在基质聚合物的熔融温度下是热稳定的，以及用于将层压材料固定到主体的皮肤或粘膜的装置，使得活性成分 成分从载体层连续释放。 还公开了用于组装装置的方法，其中能够可控地释放活性成分的热塑性基质聚合物与在基质聚合物的熔融温度下热稳定的活性成分熔融共混，使得熔融共混物 形成活性成分和热塑性基质聚合物，将该熔融共混物形成为整体载体层，然后将载体层与背衬层组合，并将该层压材料固定在主体的皮肤或粘膜上，使得 活性成分从载体层释放出来。

    Transdermal Delivery Using Encapsulated Agent Activated by Ultrasound and or Heat
    5.
    发明申请
    Transdermal Delivery Using Encapsulated Agent Activated by Ultrasound and or Heat 有权
    使用通过超声和​​/或热激活的封装剂的透皮递送

    公开(公告)号：US20110004150A1

    公开(公告)日：2011-01-06

    申请号：US12883153

    申请日：2010-09-15

    申请人： Ludwig J. Weimann

    发明人： Ludwig J. Weimann

    IPC分类号： A61K9/70 ,  A61K38/28 ,  A61K9/50 ,  A61M37/00

    CPC分类号： A61K9/0009 ,  A61K9/0014 ,  A61K9/7084 ,  A61K9/7092 ,  A61M37/00 ,  A61M37/0092 ,  A61N1/30

    摘要： A method for delivery of substance through at least one dermal layer, by providing a substance in microcapsules at a predetermined size, within a medium (150) for holding the microcapsules; placing the medium for holding the microcapsules on a surface of a patch (100) adjacent the skin (320) of a human or animal; and applying energy (200) to the patch, the energy having a characteristic of disturbing the integrity of the microcapsules, thereby resulting in release of the substance from the microcapsules. The energy may be selectively applied to release the substance at desired times. The substance may be a drug or other active agent.

    摘要翻译： 通过在用于保持微胶囊的介质（150）内通过在预定尺寸的微胶囊中提供物质来输送物质通过至少一个真皮层的方法; 将用于保持微胶囊的介质放置在与人或动物的皮肤（320）相邻的贴片（100）的表面上; 并且将能量（200）施加到贴剂上，该能量具有干扰微胶囊完整性的特征，从而导致物质从微胶囊中释放出来。 可以选择性地施加能量以在期望的时间释放物质。 该物质可以是药物或其它活性剂。

    Foam laminate transdermal patch
    6.
    发明授权
    Foam laminate transdermal patch 失效
    泡沫层压透皮贴片

    公开(公告)号：US5503844A

    公开(公告)日：1996-04-02

    申请号：US63515

    申请日：1993-05-18

    申请人： Alfred Kwiatek ,  Ludwig J. Weimann ,  Wayne C. Pollock ,  Sharad K. Govil

    发明人： Alfred Kwiatek ,  Ludwig J. Weimann ,  Wayne C. Pollock ,  Sharad K. Govil

    IPC分类号： A61K9/70 ,  A61F13/00 ,  A61F13/02

    CPC分类号： A61K9/703 ,  A61K9/7084

    摘要： Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a cellular foam layer having a first surface and a second surface, which foam layer has an active agent incorporated therein; a backing layer having an inner surface and an outer surface, wherein the inner surface is affixed to the second surface of the foam layer so that the active agent cannot permeate from the second surface of the foam layer through the outer surface of the backing layer; and means for affixing the laminate to the skin or mucosa of the host so that the active agent is capable of being continuously released from the first surface of the foam layer thereto. Methods for assembling the laminate devices are also disclosed, as are methods in which the foam layer is formed from a prepolymer solution on the backing layer. Methods are also disclosed for the polymerization of cellular urethane foams having active agents uniformly dispersed therethrough.

    摘要翻译： 公开了将活性剂控制释放到主体的皮肤或粘膜上的装置，哪些装置是具有第一表面和第二表面的泡沫层的层压体，该泡沫层具有并入其中的活性剂; 背衬层，其具有内表面和外表面，其中内表面固定到泡沫层的第二表面，使得活性剂不能通过背衬层的外表面从泡沫层的第二表面渗透; 以及用于将层压材料固定到主体的皮肤或粘膜的装置，使得活性剂能够从泡沫层的第一表面连续释放。 还公开了组装层压装置的方法，以及其中泡沫层由背衬层上的预聚物溶液形成的方法。 还公开了具有均匀分散在其中的活性剂的聚氨酯泡沫聚合的方法。

    WEARABLE DEVICE TO SCREEN OPIOID INTOXICATION
    7.
    发明申请
    WEARABLE DEVICE TO SCREEN OPIOID INTOXICATION 有权

    公开(公告)号：US20210169410A1

    公开(公告)日：2021-06-10

    申请号：US17116566

    申请日：2020-12-09

    申请人： Ghassan S. Kassab ,  Ali Dabiri ,  Ludwig J. Weimann

    发明人： Ghassan S. Kassab ,  Ali Dabiri ,  Ludwig J. Weimann

    IPC分类号： A61B5/00 ,  A61B5/1473 ,  A61B5/145

    摘要： A microneedle device comprising a membrane having an adhesive thereon and a microneedle substrate adhered to the membrane via the adhesive. The microneedle substrate may have a plurality of microneedles coupled thereto, or the microneedle substrate can comprise the plurality of microneedles. The microneedle device can be mated with a reagent container and the microneedles aligned with wells on the reagent container said wells configured to hold reagents thus comprising a system for detecting opioids or other drugs. In another embodiment, the device comprises a sweat-absorbent swatch adhered to a membrane. This embodiment can be mated to a screening pad comprising blisters of reagents on the base layer of the screening pad. Upon mating, a needle device can be used to pierce the blisters such that the reagents are released and react with the sweat absorbent swatch to indicate the presence of opioids or other drugs.