利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

165 条记录 (耗时 0.028 秒)

    Adaptors for nucleic acid constructs in transmembrane sequencing
    1.
    发明授权
    Adaptors for nucleic acid constructs in transmembrane sequencing 有权

    公开(公告)号：US11459606B2

    公开(公告)日：2022-10-04

    申请号：US15906964

    申请日：2018-02-27

    申请人： Oxford Nanopore Technologies Ltd.

    发明人： Brian McKeown

    IPC分类号： C12P19/34 ,  C12Q1/6869 ,  C07H21/04

    摘要： The invention relates to adaptors for sequencing nucleic acids. The adaptors may be used to generate single stranded constructs of nucleic acid for sequencing purposes. Such constructs may contain both strands from a double stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) template. The invention also relates to the constructs generated using the adaptors, methods of making the adaptors and constructs, as well as methods of sequencing double stranded nucleic acids.

    FORMATION OF ARRAY OF MEMBRANES AND APPARATUS THEREFOR
    4.
    发明申请
    FORMATION OF ARRAY OF MEMBRANES AND APPARATUS THEREFOR 有权

    公开(公告)号：US20220023819A1

    公开(公告)日：2022-01-27

    申请号：US17365517

    申请日：2021-07-01

    申请人： Oxford Nanopore Technologies Ltd.

    发明人： Jason Robert Hyde ,  Pedro Miguel Ortiz Bahamon ,  Clive Gavin Brown ,  Andrew John ,  Paul Raymond Mackett

    IPC分类号： B01J19/00

    摘要： An array of membranes comprising amphipathic molecules is formed using an apparatus comprising a support defining an array of compartments. Volumes comprising polar medium are provided within respective compartments and a layer comprising apolar medium is provided extending across the openings with the volumes. Polar medium is flowed across the support to displace apolar medium and form a layer in contact with the volumes, forming membranes comprising amphipathic molecules at the interfaces. In one construction of the apparatus, the support that comprises partitions which comprise inner portions and outer portions. The inner portions define inner recesses without gaps therebetween that are capable of constraining the volumes comprising polar medium contained in neighbouring inner recesses from contacting each other. The outer portions extend outwardly from the inner portions and have gaps allowing the flow of an apolar medium across the substrate.

    Biochemical analysis instrument
    5.
    发明授权
    Biochemical analysis instrument 有权

    公开(公告)号：US11169113B2

    公开(公告)日：2021-11-09

    申请号：US16170620

    申请日：2018-10-25

    申请人： Oxford Nanopore Technologies Ltd.

    发明人： Clive Gavin Brown ,  James Peter Willcocks

    IPC分类号： G01N27/00 ,  G01N33/00 ,  G01N15/00 ,  G01N27/447 ,  G01N33/487 ,  C12Q1/6869 ,  G01N15/14

    摘要： An analysis instrument comprises plural modules connected together over a data network, each module comprising an analysis apparatus operable to perform biochemical analysis of a sample. Each module comprises a control unit that controls the operation of the analysis apparatus. The control units are addressable to select an arbitrary number of modules to operate as a cluster for performing a common biochemical analysis. The control units communicate over the data network, repeatedly during the performance of the common biochemical analysis, to determine the operation of the analysis apparatus of each module required to meet the global performance targets, on the basis of measures of performance derived from the output data produced by the modules. The arrangement of the instrument as modules interacting in this manner provides a scalable analysis instrument.