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公开(公告)号：US11434225B2
公开(公告)日：2022-09-06
申请号：US16635656
申请日：2018-08-01
IPC分类号： C07D403/06
摘要： The present disclosure relates to Plinabulin solid state forms, Plinabulin salts including hydrochloride and solid state forms thereof, processes for preparation thereof and pharmaceutical compositions thereof.
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公开(公告)号：US10807953B2
公开(公告)日：2020-10-20
申请号：US16423810
申请日：2019-05-28
发明人： Tomislav Biljan , Jasna Dogan , Leonid Metsger , Sara Morasi Pipercic , Marina Ratkaj , Maja Matanovic Skugor , Yi Wang
IPC分类号： C07D211/58 , C07D233/60 , C07C259/06 , C07C269/04 , C07C271/48 , C07D233/61 , C07D273/01
摘要： The present disclosure relates to novel, safe and efficient processes for the synthesis of Pimavanserin and salts thereof, as well as novel intermediates that can be used in these processes.
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3.发明授权Pharmaceutically acceptable salt and polymorphic forms of flupirtine maleate 有权马来酸氟吡汀的药学上可接受的盐和多晶型物公开(公告)号：US08138349B2
公开(公告)日：2012-03-20
申请号：US12309260
申请日：2007-07-13
申请人： Aleksandar Danilovski , Maja Dev{hacek over (c)}ić , Marina Marinković , Ernest Me{hacek over (s)}trović , Tina Mundorfer , Iva Tunjić
发明人： Aleksandar Danilovski , Maja Dev{hacek over (c)}ić , Marina Marinković , Ernest Me{hacek over (s)}trović , Tina Mundorfer , Iva Tunjić
IPC分类号： C07D213/00 , A61K31/44
CPC分类号： C07D213/75
摘要： The present invention is concerned with new polymorphic forms of flupirtine maleate, processes for preparing the new polymorphic forms, pharmaceutical compositions containing them, therapeutic uses thereof and methods of treatment employing them.
摘要翻译： 本发明涉及马来酸氟吡汀的新型多晶型物，新型多晶型物的制备方法，含有它们的药物组合物，其治疗用途和使用它们的治疗方法。
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4.发明申请SOLID STATE FORMS OF FOSAMPRENAVIR CALCIUM SALT AND PROCESSES FOR PREPARATION THEREOF 审中-公开FOSAMPRENAVIR钙盐的固体状态及其制备方法公开(公告)号：US20110165202A1
公开(公告)日：2011-07-07
申请号：US12986125
申请日：2011-01-06
申请人： Edislav LEKSIC , Dragan SEPAC , Dubravka PAVLICIC
发明人： Edislav LEKSIC , Dragan SEPAC , Dubravka PAVLICIC
IPC分类号： A61K9/00 , C07F9/655 , A61K31/665 , A61P31/18
CPC分类号： C07F9/65515
摘要： The present invention relates to solid state forms of fosamprenavir calcium salt, process for preparing said solid state forms, and pharmaceutical compositions thereof.
摘要翻译： 本发明涉及福桑那韦钙盐的固体形式，制备所述固体形式的方法及其药物组合物。
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公开(公告)号：US20220289764A1
公开(公告)日：2022-09-15
申请号：US17624870
申请日：2020-07-10
IPC分类号： C07D498/18
摘要： The present disclosure relates to crystalline Lorlatinib:Fumaric acid, solid state forms thereof, processes for preparation N thereof, pharmaceutical compositions and methods of use thereof.
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公开(公告)号：US20210122738A1
公开(公告)日：2021-04-29
申请号：US16635656
申请日：2018-08-01
IPC分类号： C07D403/06
摘要： The present disclosure relates to Plinabulin solid state forms, Plinabulin salts including hydrochloride and solid state forms thereof, processes for preparation thereof and pharmaceutical compositions thereof.
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公开(公告)号：US10343993B2
公开(公告)日：2019-07-09
申请号：US15555092
申请日：2016-03-02
发明人： Tomislav Biljan , Jasna Dogan , Leonid Metsger , Sara Morasi Pipercic , Marina Ratkaj , Maja Matanovic Skugor , Yi Wang
IPC分类号： C07D211/58 , C07D233/60 , C07C259/06 , C07C269/04 , C07C271/48 , C07D233/61 , C07D273/01
摘要： The present disclosure relates to novel, safe and efficient processes for the synthesis of Pimavanserin and salts thereof, as well as novel intermediates that can be used in these processes.
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8.发明授权Polymorphs of eltrombopag and eltrombopag salts and processes for preparation thereof 有权埃曲波帕和埃曲波帕盐的多晶型物及其制备方法公开(公告)号：US08217021B2
公开(公告)日：2012-07-10
申请号：US13198214
申请日：2011-08-04
申请人： Edislav Leksic , Helena Ceric , Tina Mundorfer , Irena Zrinski Antonac , Zrinka Mastelic Samardzic
发明人： Edislav Leksic , Helena Ceric , Tina Mundorfer , Irena Zrinski Antonac , Zrinka Mastelic Samardzic
IPC分类号： C07D231/46 , A61K31/4152
CPC分类号： C07D231/46
摘要： New polymorphs of Eltrombopag and Eltrombopag ethanolamine salt have been obtained and characterized. These polymorphs and pharmaceutical compositions comprising them are useful, for example, in treating conditions leading to thrombocytopenia.
摘要翻译： 已经获得并表征了Eltrombopag和Eltrombopag乙醇胺盐的新多晶型物。 这些多晶型物和包含它们的药物组合物可用于例如治疗导致血小板减少症的病症。
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9.发明申请POLYMORPHS OF ELTROMBOPAG AND ELTROMBOPAG SALTS AND PROCESSES FOR PREPARATION THEREOF 有权铝土壤和铝土壤盐的聚合物及其制备方法公开(公告)号：US20120022124A1
公开(公告)日：2012-01-26
申请号：US13198214
申请日：2011-08-04
申请人： Edislav LEKSIC , Helena CERIC , Tina MUNDORFER , Irena Zrinski ANTONAC , Zrinka Mastelic SAMARDZIC
发明人： Edislav LEKSIC , Helena CERIC , Tina MUNDORFER , Irena Zrinski ANTONAC , Zrinka Mastelic SAMARDZIC
IPC分类号： A61K31/4152 , A61P7/00 , C07D231/46
CPC分类号： C07D231/46
摘要： New polymorphs of Eltrombopag and Eltrombopag ethanolamine salt have been obtained and characterized. These polymorphs and pharmaceutical compositions comprising them are useful, for example, in treating conditions leading to thrombocytopenia.
摘要翻译： 已经获得并表征了Eltrombopag和Eltrombopag乙醇胺盐的新多晶型物。 这些多晶型物和包含它们的药物组合物可用于例如治疗导致血小板减少症的病症。
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公开(公告)号：US08022093B2
公开(公告)日：2011-09-20
申请号：US13089482
申请日：2011-04-19
申请人： Edislav Leksic , Helena Ceric , Tina Mundorfer , Irena Zrinski Antonac , Zrinka Mastelic Samardzic
发明人： Edislav Leksic , Helena Ceric , Tina Mundorfer , Irena Zrinski Antonac , Zrinka Mastelic Samardzic
IPC分类号： A61K31/4152 , A61K31/655 , C07D231/46
CPC分类号： C07D231/46
摘要： New polymorphs of Eltrombopag and Eltrombopag ethanolamine salt have been obtained and characterized. These polymorphs and pharmaceutical compositions comprising them are useful, for example, in treating conditions leading to thrombocytopenia.
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