公开(公告)号：US20130296229A1

公开(公告)日：2013-11-07

申请号：US13884750

申请日：2011-11-10

申请人： Bingming He ,  Ming Li ,  Zhijun Tang ,  Xiaoming Ji

发明人： Bingming He ,  Ming Li ,  Zhijun Tang ,  Xiaoming Ji

IPC分类号： C07K7/56

CPC分类号： C07K7/56 ,  A61K38/00 ,  A61K38/12

摘要： Disclosed are a caspofungin analog and applications thereof. Said caspofungin analog is a compound having a structure as indicated in Formula (4), or pharmaceutically acceptable slats thereof. R1 can be chosen from hydroxyl, benzyloxy, phenoxy, substituted phenoxy, or substituted benzyloxy. R2, R3, R4, R5 can be chosen from hydrogen, C1-C6 alkyl, C1-C6 alkoxy, hydroxyl, benzyloxyphenyl, substituted benzyloxyphenyl, nitro, fluorine, chlorine, bromine, or iodine. Also disclosed are a preparation method for and applications of said compound.

摘要翻译： 公开了卡泊芬净类似物及其应用。 所述卡泊芬净类似物是具有式（4）所示结构的化合物或其药学上可接受的盐条。 R 1可以选自羟基，苄氧基，苯氧基，取代的苯氧基或取代的苄氧基。 R2，R3，R4，R5可以选自氢，C1-C6烷基，C1-C6烷氧基，羟基，苄氧基苯基，取代的苄氧基苯基，硝基，氟，氯，溴或碘。 还公开了所述化合物的制备方法和应用。