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公开(公告)号：US20240336657A1
公开(公告)日：2024-10-10
申请号：US18287637
申请日：2022-04-26
Inventor： Kevan M. Shokat , Qi Hu , Shizhong Dai , Hiroaki Suga , Rong Gao , Hayden Peacock
Abstract: Described herein, inter alia, are Gas peptide inhibitors and uses thereof.
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公开(公告)号：US20240262864A1
公开(公告)日：2024-08-08
申请号：US18006110
申请日：2022-06-17
Applicant: Shanghai Techwell Biopharmaceutical Co., Ltd
Inventor： Rongguo SHI , Min CHEN , Yushan GUO , Yan LI , Xiaoming JI
Abstract: The present disclosure provides an echinocandin drug impurity and preparation and purification methods and use thereof. The echinocandin drug impurity has a structure shown in Formula I:
In the present disclosure, micafungin sodium is reacted with a protonic acid aqueous solution to obtain an echinocandin drug impurity, and a high-purity echinocandin drug impurity is obtained after chromatographic purification. The present disclosure overcomes problems that an echinocandin drug impurity is prone to being degraded during the purification, and purification difficulty is high, and an HPLC purity of the obtained echinocandin drug impurity may reach 90% or more. The echinocandin drug impurity may be used as a reference substance for establishing an analysis method for use in echinocandin drug quality control.-
公开(公告)号：US20240209026A1
公开(公告)日：2024-06-27
申请号：US18501864
申请日：2023-11-03
Applicant: Protagonist Therapeutics, Inc.
Inventor： Ashok BHANDARI , Dinesh V. PATEL , Genet ZEMEDE , Brian Troy FREDERICK , Larry C. MATTHEAKIS , David LIU
IPC: C07K7/56 , A61K38/00 , A61K38/12 , A61K47/54 , A61K47/60 , A61K47/64 , C07K7/06 , C07K7/08 , C07K14/705
CPC classification number: C07K7/56 , A61K38/12 , A61K47/54 , A61K47/545 , A61K47/60 , A61K47/64 , C07K7/06 , C07K7/08 , C07K14/70546 , A61K38/00
Abstract: The invention relates to thioether monomer and dimer peptide molecules which inhibit binding of a4β7 to the mucosal addressing cell adhesion molecule (MAdCAM) in vivo.
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公开(公告)号：US12004514B2
公开(公告)日：2024-06-11
申请号：US17113764
申请日：2020-12-07
Inventor： James Leif Smith , Akshaya Ravichandran , Shien Lu , Ganyu Gu
CPC classification number: A01N63/50 , A01N43/713 , A61K38/12 , C07K7/54 , C07K7/56 , C12N9/16 , C12Y301/02 , A01N63/50 , A01N63/20
Abstract: Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar activity. This invention is directed to compositions enriched for particular occidiofungin diastereomers/conformers, methods of making compositions enriched for particular diastereomers/conformers and microorganisms suitable for producing enriched compositions of particular diastereomers/conformers. Methods of treating fungal infections or plants infected by fungi are also provided.
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公开(公告)号：US20240158443A1
公开(公告)日：2024-05-16
申请号：US18272674
申请日：2022-01-19
Inventor： Michael Stowell , William Old , Brady Worrell , John Mayer
Abstract: The invention described herein includes a novel platform for the development of novel shapeshifting drug-like compounds that overcome physical mass limitations as they possess the ability to interconvert internally and spontaneously, i.e., shapeshift, between multiple chemical structures with varying pharmacophore properties. In one preferred embodiment, the invention include systems, methods, and compositions for the synthesis of novel bullvalene amino acid (Bvas) compounds that may further be incorporated into Shape Shifting Cyclic Peptides (SSCP) with varying pharmacophore properties and their use as novel therapeutic compounds.
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Patent Agency Ranking
公开(公告)号：US20230295235A1
公开(公告)日：2023-09-21
申请号：US18011997
申请日：2021-06-25
Applicant: ZEALAND PHARMA A/S
Inventor： Andrew Roughton , Narendrakumar Patel , Adam Paul Kafal , Manuel Perez Vazquez , Jennifer Hickey , Sai Kumar Chakka , Monzur Morshed
Abstract: Abstract: Compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, are described. The compounds are α4β7 antagonists and are useful in the prevention or treatment of inflammatory conditions and/or autoimmune diseases, especially inflammatory bowel disease.
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公开(公告)号：US11746126B2
公开(公告)日：2023-09-05
申请号：US17060409
申请日：2020-10-01
Applicant: BicycleRD Limited
Inventor： Gavin Bennett , Daniel Paul Teufel
CPC classification number: C07K7/56 , A61K49/0032 , A61K49/0043 , A61K49/0056 , A61K51/088 , C07K7/08 , C07K14/001
Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
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公开(公告)号：US20180346518A1
公开(公告)日：2018-12-06
申请号：US15752936
申请日：2016-08-16
Applicant: BAYER ANIMAL HEALTH GMBH
Inventor： Guido Schiffer , Stefan Falker , Gert Daube , Kristine Fraatz , Wolfgang Wiehl , Johannes Kobberling
Abstract: The present invention relates to lysobactin for use in the treatment of bovine mastitis.
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公开(公告)号：US20180327453A1
公开(公告)日：2018-11-15
申请号：US15774141
申请日：2016-11-07
Applicant: Stephen FIACCO , Amanda HARDY , EVORX TECHNOLOGIES, INC.
Inventor： Stephen FIACCO , Amanda HARDY
Abstract: Disclosed are highly potent peptides, peptide conjugates, host cells and compositions containing one or more of these peptides, peptide conjugates and/or host cells that are useful to inhibit the growth of a breast cancer cell or treat breast cancer in a patient in need of such treatment.
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公开(公告)号：US20180200378A1
公开(公告)日：2018-07-19
申请号：US15862964
申请日：2018-01-05
Applicant: Bicycle Therapeutics Limited
Inventor： Gavin Bennett , Daniel Paul Teufel
Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
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