公开(公告)号：US20050143472A1

公开(公告)日：2005-06-30

申请号：US10504601

申请日：2003-02-13

申请人： Tianyun Wu ,  William McIntire

发明人： Tianyun Wu ,  William McIntire

IPC分类号： A61K38/00 ,  C12N9/06 ,  G01N33/573 ,  C12Q1/68 ,  A61K31/13 ,  C07H21/04

CPC分类号： C12N9/0032 ,  A61K38/00 ,  C12Y105/03013 ,  G01N33/573

摘要： This invention relates to compositions and methods for the treatment of pathologies associated with intracellular polyamine dysregulation. In particular, the present invention provides compositions and methods involving mammalian polyamine oxidase (PAO) to treat cancer, cell damage, tissue damage caused by ischemia/reperfusion, inflammation, traumatic brain injury, stroke and tissue developmental disorders. Methods for diagnosis and prognosis of cancer and other diseases are also provided by the present invention.

摘要翻译： 本发明涉及用于治疗与细胞内多胺失调相关的病理学的组合物和方法。 特别地，本发明提供涉及哺乳动物多胺氧化酶（PAO）以治疗癌症，细胞损伤，由缺血/再灌注，炎症，创伤性脑损伤，中风和组织发育障碍引起的组织损伤的组合物和方法。 癌症及其他疾病的诊断和预后的方法也由本发明提供。