公开(公告)号：US06841549B1

公开(公告)日：2005-01-11

申请号：US10018688

申请日：2000-06-30

申请人： Osamu Asano ,  Hitoshi Harada ,  Seiji Yoshikawa ,  Nobuhisa Watanabe ,  Takashi Inoue ,  Tatsuo Horizoe ,  Nobuyuki Yasuda ,  Kaya Ohashi ,  Hiroe Minami ,  Junsaku Nagaoka ,  Manabu Murakami ,  Seiichi Kobayashi ,  Isao Tanaka ,  Tsutomu Kawata ,  Naoyuki Shimomura ,  Hiroshi Akamatsu ,  Naoki Ozeki ,  Toshikazu Shimizu ,  Kenji Hayashi ,  Toyokazu Haga ,  Shigeto Negi ,  Toshihiko Naito

发明人： Osamu Asano ,  Hitoshi Harada ,  Seiji Yoshikawa ,  Nobuhisa Watanabe ,  Takashi Inoue ,  Tatsuo Horizoe ,  Nobuyuki Yasuda ,  Kaya Ohashi ,  Hiroe Minami ,  Junsaku Nagaoka ,  Manabu Murakami ,  Seiichi Kobayashi ,  Isao Tanaka ,  Tsutomu Kawata ,  Naoyuki Shimomura ,  Hiroshi Akamatsu ,  Naoki Ozeki ,  Toshikazu Shimizu ,  Kenji Hayashi ,  Toyokazu Haga ,  Shigeto Negi ,  Toshihiko Naito

IPC分类号： A61P3/10 ,  A61P43/00 ,  C07D471/04 ,  C07D473/00 ,  C07D473/34 ,  C07D473/40 ,  A16K31/33 ,  C07D239/70 ,  C07D471/00 ,  C07D487/00 ,  A16K31/52

CPC分类号： C07D471/04 ,  C07D473/00 ,  C07D473/34 ,  C07D473/40

摘要： The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action.That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, is effective for preventing or treating diabetes mellitus and diabetic complications, and is represented by the formula (I); (wherein R1 represents e.g. an amino group which may be substituted with an alkyl group; R2 represents e.g. hydrogen atom, an alkyl group, a cycloalkyl group or an alkyl group, alkenyl group or alkynyl group which may be substituted with hydrox etc.; R3 represents e.g. an optionally substituted alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, pyridinone group, pyrimidinone group or piperadinone group; Ar represents e.g. an optionally substituted aryl or heteroaryl group; and Q and W are the same as or different from each other and each represents N or CH), a pharmacologically acceptable salt or hydrates thereof.

摘要翻译： 本发明提供了一种基于腺苷A2受体拮抗剂作用的新型糖尿病和糖尿病并发症的预防或治疗剂。即提供了具有腺苷A2受体拮抗剂作用的新颖的缩合咪唑化合物，是 有效预防或治疗糖尿病和糖尿病并发症，并由式（I）表示;（其中R 1表示例如可被烷基取代的氨基; R 2表示例如氢原子， 可以被羟基取代的烷基，环烷基或烷基，烯基或炔基; R 3表示例如任选取代的烷基，烯基，炔基，芳基，杂芳基， 吡啶酮基，嘧啶酮基或哌嗪酮基; Ar表示例如任选取代的芳基或杂芳基; Q和W彼此相同或不同，每个代表 N或CH），其药理学上可接受的盐或其水合物。