公开(公告)号：US06413518B1

公开(公告)日：2002-07-02

申请号：US09672595

申请日：2000-09-28

申请人： David M. Koelle ,  Hongbo Chen ,  Lawrence Corey ,  Nancy Ann Hosken ,  Patrick McGowan ,  Steven P. Fling ,  Christine M. Posavad

发明人： David M. Koelle ,  Hongbo Chen ,  Lawrence Corey ,  Nancy Ann Hosken ,  Patrick McGowan ,  Steven P. Fling ,  Christine M. Posavad

IPC分类号： A16K39245

CPC分类号： C07K14/005 ,  A61K35/12 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/5154 ,  A61K2039/53 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2710/24143

摘要： The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.