公开(公告)号：US5290776A

公开(公告)日：1994-03-01

申请号：US886798

申请日：1992-05-21

申请人： Peter W. R. Caulkett ,  Geraint Jones ,  Michael G. Collis ,  Simon M. Poucher

发明人： Peter W. R. Caulkett ,  Geraint Jones ,  Michael G. Collis ,  Simon M. Poucher

IPC分类号： A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  C07D487/04 ,  C07D405/14 ,  A51K31/53

CPC分类号： C07D487/04

摘要： A compound of the formula I ##STR1## wherein: R.sup.1 is hydrogen, (1-6C)alkyl, or (1-4C)alkanoyl;R.sup.2 is phenyl, a C-linked aromatic 5- or 6-membered heterocyclic ring containing one of oxygen and sulphur and/or one or two nitrogen, or (1-8C)alkyl, alkenyl or alkynyl unsubstituted or substituted by a phenyl or a C-linked aromatic 5- or 6-membered heterocylic ring containing one of oxygen and sulphur and/or one or two nitrogen, any phenyl being unsubstituted or substituted by one, two or three of (1-4C)alkyl, (1-4C)alkoxy, halogen, trifluoromethyl, hydroxy, benzyloxy and (1-5C)alkanoyloxy;A is N or CT in which T is hydrogen or (1-4C)alkyl;or a pharmaceutically acceptable salt thereof, processes for the manufacture of the compounds, and pharmaceutical compositions containing them. The compounds are useful as adenosine antagonists.

摘要翻译： 式I化合物（*化学结构*）Ⅰ其中：R1为氢，（1-6C）烷基或（1-4C）烷酰基; R2是苯基，含有氧和硫之一和/或一个或两个氮的C-连接的芳香族5-或6-元杂环，或未被取代或被苯基取代或（1-8C）烷基， 含有一个氧和硫和/或一个或两个氮的C连接的芳族5-或6-元杂环，任何未被取代或被一个，两个或三个（1-4C）烷基取代的苯基（1-4C ）烷氧基，卤素，三氟甲基，羟基，苄氧基和（1-5C）烷酰氧基; A是N或CT，其中T是氢或（1-4C）烷基; 或其药学上可接受的盐，用于制备化合物的方法和含有它们的药物组合物。 这些化合物可用作腺苷拮抗剂。