公开(公告)号：US06699859B1

公开(公告)日：2004-03-02

申请号：US09582445

申请日：2000-06-26

申请人： William Robert Carling ,  Andrew Mitchinson ,  Leslie Joseph Street

发明人： William Robert Carling ,  Andrew Mitchinson ,  Leslie Joseph Street

IPC分类号： A61P2508

CPC分类号： C07D487/04

摘要： 1,2,4-triazolo[4,3-b]pyridazine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position, a substituted alkoxy moiety at the 6-position, an optionally substituted N-linked nitrogen-containing aliphatic ring at the 7-position, and a chloro at the 8-position are selective ligands for GABAZA receptors, in particular having high affinity for the &agr;2 and/or &agr;3 subunit thereof, are useful in the treatment of anxiety and convulsions.

摘要翻译： 具有任选取代的环烷基，3-位上的苯基或杂芳基取代基，6-位取代的烷氧基部分，任选取代的N-连接的氮原子的1,2,4-三唑并[4,3-b]哒嗪衍生物 含有7位的脂肪环，8位上的氯是GABAZA受体的选择性配体，特别是对其α2和/或α3亚基具有高亲和力，可用于治疗焦虑和抽搐。