公开(公告)号：US5891456A

公开(公告)日：1999-04-06

申请号：US885675

申请日：1997-06-30

申请人： Jaymin C. Shah ,  Saleh Allababidi

发明人： Jaymin C. Shah ,  Saleh Allababidi

IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/28 ,  A61R2/02 ,  A01N25/12 ,  A61K47/30

CPC分类号： A61K9/0024 ,  A61K9/2013 ,  A61K9/2031 ,  A61K9/282

摘要： A method to administer a drug locally to a subject in which biodegradable dosage forms that contain the drug are implanted at a localized site beneath the skin of the subject whereupon the dosage forms release the drug over a desired period of time at a substantially continuous rate. Glyceryl monostearate based compositions that accomplish the method are also provided. Compositions are further provided that affect the release profile or release duration of drugs that are released from the compositions, as are methods that employ these varying release profiles to provide implantable dosage forms that release drugs at a prescribed rate over a prescribed period of time. The compositions are particularly well adapted to implantable dosage forms because they biodegrade quickly to an acceptable level after delivering the drug.

摘要翻译： 将药物局部施用于其中含有药物的可生物降解剂型的受试者的方法植入受试者皮肤下方的局部位置，由此剂型以基本上连续的速率在期望的时间段内释放药物。 也提供了完成该方法的基于单硬脂酸甘油酯的组合物。 进一步提供影响从组合物释放的药物的释放曲线或释放持续时间的组合物，使用这些变化释放曲线的方法提供在规定时间内以规定速率释放药物的可植入剂型。 组合物特别适合于可植入的剂型，因为它们在递送药物之后快速生物降解至可接受的水平。

公开(公告)号：US6083524A

公开(公告)日：2000-07-04

申请号：US944739

申请日：1997-10-06

申请人： Amarpreet S. Sawhney ,  David J. Enscore ,  Stephen D. Goodrich ,  William C. Nason ,  Fei Yao ,  Douglas Weaver ,  Peter K. Jarrett ,  Arthur J. Coury ,  Ronald S. Rudowsky ,  Michelle D. Powell ,  Luis Z. Avila ,  Shikha P. Barman

发明人： Amarpreet S. Sawhney ,  David J. Enscore ,  Stephen D. Goodrich ,  William C. Nason ,  Fei Yao ,  Douglas Weaver ,  Peter K. Jarrett ,  Arthur J. Coury ,  Ronald S. Rudowsky ,  Michelle D. Powell ,  Luis Z. Avila ,  Shikha P. Barman

IPC分类号： A61K9/16 ,  A61L24/00 ,  A61L24/04 ,  A61L26/00 ,  A61L31/06 ,  A61L31/14 ,  C08G63/64 ,  A61R2/02 ,  A61K31/74

CPC分类号： C08G63/64 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L31/06 ,  A61L31/148 ,  A61K9/1635

摘要： Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.

摘要翻译： 描述了包括由碳酸酯或二恶烷酮基团形成的至少一种可水解键，至少一种水溶性聚合物嵌段和至少一种可聚合基团的水溶性大分子单体及其制备方法和用途。 大分子单体优选在长波长紫外光或可见光激发的影响下使用自由基引发剂进行聚合。 生物降解发生在延伸低聚物内的连接处，并导致无毒且容易从体内去除的碎片。 大分子单体可用于包封细胞，以受控的方式递送预防性，治疗性或诊断性药物，堵塞组织中的渗漏，防止外科手术后的粘连形成，暂时保护或分离组织表面，以及将组织粘附或密封在一起。