公开(公告)号：US20020062049A1

公开(公告)日：2002-05-23

申请号：US09950905

申请日：2001-09-12

申请人： BASF Aktiengesellschaft

发明人： William Wakefield Wood

IPC分类号： C07C041/22

CPC分类号： C07C17/263 ,  C07C17/2637 ,  C07C22/08 ,  C07C41/30 ,  C07C43/29 ,  C07C2601/02

摘要： A two-step process for the preparation of fluoroolefin compounds of formula I 1 wherein R is hydrogen or alkyl, and R1 is alkyl or cyclopropyl, or R and R1 are taken together with the carbon atom to which they are attached to form a cyclopropyl group; Ar is phenyl or naphthyl both of which are optionally substituted; Ar1 is phenoxyphenyl, biphenyl, phenyl, benzylphenyl, or benzoylphenyl, all of which may be optionally substituted, comprising reacting fluorobromoolefin compounds of formula II 2 with organozinc compounds of formula III or IV 3 in the presence of a palladium catalyst and a solvent, which compounds of formula II are obtained by reacting aldehyde compounds of formula V 4 with (a) fluorotribromomethane, (b) a tri(substituted)phosphine or a hexaalkylphosphoramide or a mixture thereof, and (c) zinc, in the presence of a solvent, compounds of formula II.

摘要翻译： 制备式I的氟烯烃化合物的两步法，其中R是氢或烷基，R 1是烷基或环丙基，或R和R 1与它们所连接的碳原子一起形成环丙基; Ar是任选被取代的苯基或萘基; Ar1是苯氧基苯基，联苯基，苯基，苄基苯基或苯甲酰基苯基，所有这些可以任选被取代，包括在钯催化剂和溶剂的存在下使式II的氟代溴代烯烃化合物与式III或IV的有机锌化合物反应， 式II的化合物是通过使式V的醛化合物与（a）氟代溴甲烷，（b）三（取代的）膦或六烷基磷酰胺或其混合物的醛化合物反应而得到的，和（c）锌在溶剂存在下， 二，