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公开(公告)号:US07253194B2
公开(公告)日:2007-08-07
申请号:US10333871
申请日:2001-07-24
申请人: Robert C Reid , Christopher I Clark , Karl Hansford , Martin J Stoermer , Ross P McGeary , David P Fairlie , Karl Schafer
发明人: Robert C Reid , Christopher I Clark , Karl Hansford , Martin J Stoermer , Ross P McGeary , David P Fairlie , Karl Schafer
IPC分类号: A61K31/44 , A61K31/165 , A61K31/351 , C07C233/08 , C07C213/46
CPC分类号: C07D213/30 , C07C233/51 , C07C235/12 , C07C271/22 , C07D209/20 , C07D213/55 , C07D213/56 , C07D233/64 , C07D257/04 , C07F9/4006 , C07F9/4075
摘要: The present invention relates generally to amino acid derivatives and to methods of making the same. In particular, the invention relates to compounds bearing a stereochemical identity, that is, the same stereochemistry, with the chiral α-carbon of D-α-amino acids and their use in methods of therapy, including the treatment of inflammatory diseases, and to compositions and enantiomeric mixtures containing them.
摘要翻译: 本发明一般涉及氨基酸衍生物及其制备方法。 特别地,本发明涉及具有立体化学特征的化合物,即与D-α-氨基酸的手性α-碳相同的立体化学结构,以及它们在治疗方法中的应用,包括治疗炎性疾病,以及 组合物和含有它们的对映体混合物。