公开(公告)号：US06204391B1

公开(公告)日：2001-03-20

申请号：US09246011

申请日：1998-09-21

申请人： Simon H. Friedman ,  Raymond F. Schinazi ,  Fred Wudl ,  Craig L. Hill ,  Diane L. DeCamp ,  Rintje P. Sijbesma ,  George L. Kenyon

发明人： Simon H. Friedman ,  Raymond F. Schinazi ,  Fred Wudl ,  Craig L. Hill ,  Diane L. DeCamp ,  Rintje P. Sijbesma ,  George L. Kenyon

IPC分类号： C07C22932

CPC分类号： C07C57/50 ,  C07C13/64 ,  C07C49/255 ,  C07C55/00 ,  C07C211/27 ,  C07C211/42 ,  C07C211/50 ,  C07C233/36 ,  C07C2601/00 ,  C07C2601/14 ,  C07C2603/18 ,  C07C2603/94 ,  C07D231/56 ,  C07D233/64 ,  C07D239/26 ,  C07D261/08 ,  C07D471/10 ,  C07D487/10 ,  Y10S977/904

摘要： A water soluble derivative of buckministerfullerene (C60) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containing 1 to 20 carbon atoms and optionally further containing oxygen or nitrogen.