公开(公告)号：US06204380B1

公开(公告)日：2001-03-20

申请号：US09284799

申请日：1999-04-21

申请人： Takashi Furukawa

发明人： Takashi Furukawa

IPC分类号： C07C25176

CPC分类号： C07D277/68 ,  C07C251/76 ,  C07D237/14 ,  C07D265/36

摘要： Carboxylic acid ester derivatives of formula (1): wherein R is C1-C6 alkyl, R2 and R3 are independently hydrogen or C1-C3 alkyl, and Q is optionally substituted phenyl, can be easily converted by ring closing into pyridazin-3-one derivatives of formula (7): The carboxylic acids of formula (1) can be produced by reacting hydrazone compounds of formula (5): wherein R3 and Q are as defined above, with malonic acid monoester derivatives of formula (6): wherein R and R2 are as defined above, in the presence of a base.

摘要翻译： 式（1）的羧酸酯衍生物：其中R是C1-C6烷基，R2和R3独立地是氢或C1-C3烷基，Q是任选取代的苯基，可以容易地通过闭环转化成哒嗪-3-酮 式（7）的衍生物：式（1）的羧酸可以通过使式（5）的腙化合物（其中R 3和Q如上所定义）与式（6）的丙二酸单酯衍生物反应制备：其中R 和R2如上所定义，在碱的存在下。