公开(公告)号：US06566506B2

公开(公告)日：2003-05-20

申请号：US09545066

申请日：2000-04-07

申请人： Richard B. Greenwald ,  Anthony J. Martinez

发明人： Richard B. Greenwald ,  Anthony J. Martinez

IPC分类号： C07C27110

CPC分类号： C12N11/08 ,  A61K47/60 ,  C07K17/08 ,  C08G65/329 ,  C08G65/3322 ,  C08G65/33396 ,  C08G65/337 ,  C08G65/338

摘要： Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating life in vivo. Substantially fewer sites on the biologically active material are used as attachment sites. Methods of forming the polymer, conjugating the polymers with biologically active moieties and methods of using the conjugates are also disclosed.

公开(公告)号：US06710203B2

公开(公告)日：2004-03-23

申请号：US09863558

申请日：2001-05-23

申请人： John H. Clements ,  Howard P. Klein ,  Edward T. Marquis ,  James R. Machac, Jr.

发明人： John H. Clements ,  Howard P. Klein ,  Edward T. Marquis ,  James R. Machac, Jr.

IPC分类号： C07C27110

CPC分类号： C07C269/00 ,  C07C271/16

摘要： A method of preparing hydroxyalkylcarbamates from six-membered cyclic carbonates. The method involves reacting a six-membered cyclic carbonate with anhydrous ammonia or aqueous ammonium hydroxide. The present invention also provides for hydroxyalkylcarbamates prepared from six-membered cyclic carbonates, and for coating compositions comprising hydroxyalkylcarbamates prepared according to the present invention.

摘要翻译： 从六元环状碳酸酯制备羟烷基氨基甲酸酯的方法。 该方法包括使六元环状碳酸酯与无水氨水或氢氧化铵水溶液反应。 本发明还提供由六元环状碳酸酯制备的羟烷基氨基甲酸酯，以及包含根据本发明制备的羟烷基氨基甲酸酯的涂料组合物。