公开(公告)号：US06646160B2

公开(公告)日：2003-11-11

申请号：US09563683

申请日：2000-05-03

申请人： Thaddeus S. Franczyk, II ,  William L. Moench, Jr.

发明人： Thaddeus S. Franczyk, II ,  William L. Moench, Jr.

IPC分类号： C07C51291

CPC分类号： C07C227/02 ,  C07C229/08 ,  C07C229/12 ,  C07C229/16

摘要： The present invention provides a new and useful improvement in the process to manufacture a carboxylic acid salt, particularly an amino carboxylic acid salt, from a primary alcohol, particularly a primary aminoalcohol. The process of manufacturing amino carboxylic acid salts comprises contacting an aqueous solution of a primary aminoalcohol with a strong hydroxide base selected from the group consisting of an alkali metal hydroxide, an alkaline earth metal hydroxide, an ammonium hydroxide compound including a tetraalkyl ammonium hydroxide, or the like, in the presence of an effective amount of a catalyst. The catalyst comprises one or more of elements selected from the group consisting of copper, cobalt, nickel, and cadmium as well as optionally lesser amounts of chromium, titanium, niobium, tantalum, zirconium, vanadium, molybdenum, manganese, tungsten, cobalt, nickel, or mixtures thereof. The reaction mixture contains less than about 3000 ppm, preferably less than about 500 ppm, more preferably less than about 100 ppm of oxidized copper (Cu+ and/or Cu2+) during the reaction. The concentration of oxidizing agents in the reactants is minimized to prevent formation of oxidized copper from metallic copper catalyst.

摘要翻译： 本发明提供了从伯醇，特别是伯氨基醇制备羧酸盐，特别是氨基羧酸盐的方法中的新的和有用的改进。 制备氨基羧酸盐的方法包括将伯氨基醇的水溶液与选自碱金属氢氧化物，碱土金属氢氧化物，氢氧化铵，氢氧化四烷基铵或氢氧化四烷基铵的强氢氧化物碱 在有效量的催化剂存在下进行。 催化剂包含一种或多种选自铜，钴，镍和镉的元素，以及任选少量的铬，钛，铌，钽，锆，钒，钼，锰，钨，钴，镍 ，或其混合物。 反应混合物在反应期间含有小于约3000ppm，优选小于约500ppm，更优选小于约100ppm的氧化铜（Cu 2+和/或Cu 2+）。 反应物中氧化剂的浓度被最小化以防止金属铜催化剂形成氧化铜。