公开(公告)号：US06372733B1

公开(公告)日：2002-04-16

申请号：US09477246

申请日：2000-01-04

申请人： Charles G. Caldwell ,  Malcolm Maccoss ,  William K. Hagmann ,  Shrenik K. Shah ,  Kothandaraman Shankaran ,  Karla L. Furman

发明人： Charles G. Caldwell ,  Malcolm Maccoss ,  William K. Hagmann ,  Shrenik K. Shah ,  Kothandaraman Shankaran ,  Karla L. Furman

IPC分类号： C07D2806

CPC分类号： C07D281/06 ,  C07D243/08 ,  C07D267/16 ,  C07D337/04

摘要： Disclosed herein are compounds of Formula I and pharmaceutically acceptable salts thereof which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders, including neurodegenerative disorders, disorders of gastrointestinal motility and inflammation. These diseases and disorders include hypotension, septic shock, toxic shock syndrome, hemodialysis, IL-2 therapy such as in in cancer patients, cachexia, immunosuppression such as in transplant therapy, autoimmune and/or inflammatory indications including sunburn, eczema or psoriasis and respiratory conditions such as bronchitis, asthma, oxidant-induced lung injury and acute respiratory distress (ARDS), glomerulonephritis, restenosis, inflammatory sequelae of viral infections, myocarditis, heart failure, atherosclerosis, osteoarthritis, rheumatoid arthritis, septic arthritis, chronic or inflammatory bowel disease, ulcerative colitis, Crohn's disease, systemic lupus erythematosis (SLE), ocular conditions such as ocular hypertension, retinitis and uveitis, type 1 diabetes, insulin-dependent diabetes mellitus and cystic fibrosis.

摘要翻译： 本发明公开了已发现可用于治疗一氧化氮合酶介导的疾病和病症（包括神经退行性疾病，胃肠蠕动和炎症病症）的式I化合物及其药学上可接受的盐。 这些疾病和障碍包括低血压，脓毒性休克，中毒性休克综合征，血液透析，诸如癌症患者中的IL-2治疗，恶病质，免疫抑制如移植治疗，自身免疫和/或炎性指征，包括晒伤，湿疹或银屑病和呼吸 诸如支气管炎，哮喘，氧化剂诱发的肺损伤和急性呼吸窘迫（ARDS），肾小球性肾炎，再狭窄，病毒感染的炎症后遗症，心肌炎，心力衰竭，动脉粥样硬化，骨关节炎，类风湿性关节炎，脓毒性关节炎，慢性或炎性肠病 溃疡性结肠炎，克罗恩病，系统性红斑狼疮（SLE），眼部疾病如眼高压，视网膜炎和葡萄膜炎，1型糖尿病，胰岛素依赖性糖尿病和囊性纤维化。