专利检索 ipc:"C07D33504" 第 1 页

1.

发明授权
Heteroarotinoids containing urea or thiourea linker 有权
标题翻译：含有脲或硫脲接头的杂环类似物

公开(公告)号：US06586460B1

公开(公告)日：2003-07-01

申请号：US09824547

申请日：2001-04-02

申请人： Kenneth Darrell Berlin , Doris M. Benbrook , Eldon C. Nelson

发明人： Kenneth Darrell Berlin , Doris M. Benbrook , Eldon C. Nelson

IPC分类号： C07D33504

CPC分类号： C07D335/06 , C07D311/58 , C07D311/76

摘要： Compounds, known as heteroarotinoids, having varying abilities to inhibit growth of certain cancerous cells, induce normal cell differentiation, and induce apoptosis or death of cancerous cells, of the general formula: in which: Ar and Ar′ denote aryl substituents, and wherein at least one of said aryl substituents comprises an aromatic ring having at least one heteroatom in a fused, partially saturated ring; W denotes O or S; and Q denotes H or i-C3H7.

摘要翻译： 被称为杂亚油酸的化合物具有不同的抑制某些癌细胞生长的能力，诱导正常细胞分化，诱导癌细胞凋亡或死亡，其通式如下：其中Ar和Ar'表示芳基取代基，其中在所述芳基取代基中的至少一个包括在稠合部分饱和环中具有至少一个杂原子的芳环; W表示O或S; 且Q表示H或i-C 3 H 7。

2.

发明授权
Process for preparing substituted benzo[1,2-G]-chrome-3-ene, benzo[1,2-G]-thiochrom-3-ene and benzo[1,2-G]-1,2-dihydroquinoline derivatives 失效
标题翻译：取代苯并[1,2-G] - 色烯-3-烯，苯并[1,2-G] - 硫代色烯-3-烯和苯并[1,2-G] -1,2-二氢喹啉衍生物的制备方法

公开(公告)号：US06211385B1

公开(公告)日：2001-04-03

申请号：US09492492

申请日：2000-01-27

申请人： Vidyasagar Vuligonda , Roshantha A. Chandraratna

发明人： Vidyasagar Vuligonda , Roshantha A. Chandraratna

IPC分类号： C07D33504

CPC分类号： C07D307/92

摘要： Compounds of Formula 1 where the symbols have the meaning disclosed in the specification are prepared by reaction of a compound of Formula 2 with an organometal reagent R—M to provide a compound of Formula 3 that is reacted with the reagent X3—Y(R2)—A—B in the presence of a catalyst to provide the compounds of Formula 1.

摘要翻译： 符号具有本说明书中公开的含义的式1化合物通过式2的化合物与有机金属试剂RM的反应制备，得到式3的化合物，其在存在下与试剂X3-Y（R2）-AB反应的催化剂以提供式1的化合物。