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公开(公告)号:US4252953A
公开(公告)日:1981-02-24
申请号:US35037
申请日:1979-05-01
申请人: Kuo S. Yang
发明人: Kuo S. Yang
IPC分类号: C07D505/06 , A61K31/5365 , A61K31/545 , A61P31/04 , C07D498/04 , C07D505/00 , C07D505/22 , C07D265/12
CPC分类号: C07D505/00
摘要: Crystalline D-diammonium salt represented by the formula ##STR1## a useful pharmaceutical form of the corresponding antibiotic diacid is provided and processes for the preparation thereof.
摘要翻译: 提供由式“IMAGE”表示的相应抗生素二酸的有用药物形式的结晶D-二铵盐及其制备方法。
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公开(公告)号:US4226864A
公开(公告)日:1980-10-07
申请号:US826818
申请日:1977-08-22
申请人: Masayuki Narisada , Teruji Tsuji , Mitsuru Yoshioka , Matsumura Hiromu , Yoshio Hamashima , Sadao Hayashi , Wataru Nagata
发明人: Masayuki Narisada , Teruji Tsuji , Mitsuru Yoshioka , Matsumura Hiromu , Yoshio Hamashima , Sadao Hayashi , Wataru Nagata
IPC分类号: C07D505/06 , A61K31/535 , A61K31/5365 , A61P31/00 , A61P31/04 , C07D501/36 , C07D505/00 , C07D505/20 , C07D505/22 , C07D265/04 , C07D413/02
CPC分类号: C07D505/00 , Y02P20/55
摘要: Antibacterial 7-substituted aminoacetamido oxadethiacephalosporins of the formula: ##STR1## [wherein R is substituted amino, substituted phenyl, or 5- or 6-membered hetero ring; Ar is aryl; Y is hydrogen or methoxy; Het is 5- or 6-membered aromatic hetero ring; and Z is hydroxy or carboxy protecting group] preparable e.g. by acylation of 7.alpha.-methoxy-7.beta.-amino-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivatives, are highly active against gram-positive and gram-negative bacteria, especially those resistant to other cephalosporins and penicillins.
摘要翻译: 具有下式的抗菌7-取代氨基乙酰氨基恶二硫醚类:其中R为取代氨基,取代苯基或5-或6-元杂环; Ar为芳基; Y是氢或甲氧基; Het是5-或6-元芳族杂环; 和Z是羟基或羧基保护基] 通过酰化7α-甲氧基-7β-氨基-3-杂环硫代甲基-3-头孢烯-4-羧酸衍生物对革兰氏阳性和革兰氏阴性细菌,特别是对其它头孢菌素和青霉素具有抗性的那些是高度活性的。
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