公开(公告)号：US06828424B2

公开(公告)日：2004-12-07

申请号：US10116064

申请日：2002-04-05

申请人： John M. Greene ,  Craig A. Rosen

发明人： John M. Greene ,  Craig A. Rosen

IPC分类号： C07K1638

CPC分类号： C07K14/8146 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： A human tissue inhibitor of metalloproteinases-4 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for the treatment of diseases, including arthritis and cancer. Antagonists against such polypeptides and their use as a therapeutic to resorb scar tissue are also disclosed. Diagnostic assays for detecting levels of human TIMP-4 protein and mutations in human TIMP-4 nucleic acid sequence are also disclosed.

摘要翻译： 金属蛋白酶-4多肽的人体组织抑制剂和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽治疗包括关节炎和癌症在内的疾病的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗疤痕组织再吸收的用途。 还公开了用于检测人类TIMP-4蛋白水平和人TIMP-4核酸序列突变的诊断测定法。

公开(公告)号：US06656746B2

公开(公告)日：2003-12-02

申请号：US09904621

申请日：2001-07-13

申请人： Cindy A. Sprecher ,  Walt Kisiel ,  Donald C. Foster

发明人： Cindy A. Sprecher ,  Walt Kisiel ,  Donald C. Foster

IPC分类号： C07K1638

CPC分类号： C07K14/8114 ,  A61K38/00

摘要： The present invention provides isolated DNA molecules comprising a DNA segment encoding novel human Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human Kunitz-type inhibitor wherein said first DNA segment is operably linked to additional DNA segments required for the expression for the first DNA segment, host cells containing such DNA constructs, methods for producing proteins from the host cells, as well as antibodies directed towards same.

摘要翻译： 本发明提供了分离的DNA分子，其包含编码新型人Kunitz型抑制剂的DNA区段。 还提供了包含编码新型人Kunitz型抑制剂的第一DNA区段的DNA构建体，其中所述第一DNA区段可操作地连接到第一DNA区段表达所需的其它DNA区段，含有这种DNA构建体的宿主细胞， 来自宿主细胞的蛋白质，以及针对其的抗体。