公开(公告)号：US07098341B2

公开(公告)日：2006-08-29

申请号：US10876748

申请日：2004-06-25

申请人： Yong-Tae Lee ,  Hye-Sung Lee ,  Yoo-Jung Kim

发明人： Yong-Tae Lee ,  Hye-Sung Lee ,  Yoo-Jung Kim

IPC分类号： C07P211/72

CPC分类号： G01N33/5308 ,  C07F9/2458 ,  C07F9/58

摘要： The present invention relates to a process for preparing haptens for immunoassay of phosphorothioate pesticides, which comprises the steps of reacting O-methyl(ethyl) dichlorothiophosphate with a phenolic compound to obtain O-methyl(ethyl) O-aryl chlorothiophosphate, and reacting the O-(methyl)ethyl O-aryl chlorothiophosphate thus obtained with aminocarboxylic acid to give desired haptens. In accordance with the present invention, haptens having a structure of O-methyl(ethyl) O-aryl N-(carboxyalkyl)phosphoramidothioate or O-methyl(ethyl) O-aryl N-alkyl-N-(carboxyalkyl)phosphoramidothioate can be simply prepared with a high yield by employing two-step processes in a cost-efficient manner.

摘要翻译： 本发明涉及一种用于制备硫代磷酸酯农药免疫测定的半抗原的方法，其包括使O-甲基（乙基）二氯硫代磷酸酯与酚类化合物反应以获得O-甲基（乙基）O-芳基氯代硫代磷酸酯，并使O - （甲基）乙基O-芳基氯代硫代磷酸酯，由此得到所需的半抗原。 根据本发明，具有O-甲基（乙基）O-芳基N-（羧基烷基）氨基硫代磷酸酯或O-甲基（乙基）O-芳基N-烷基-N-（羧基烷基）氨基硫代磷酸酯的结构的半抗原可以简单地 通过以成本有效的方式采用两步法制备高产率。