公开(公告)号：US07244307B2

公开(公告)日：2007-07-17

申请号：US10513154

申请日：2003-05-08

申请人： Linda Jane McCausland

发明人： Linda Jane McCausland

IPC分类号： C30B15/01

CPC分类号： B01D9/0013 ,  B01D9/005 ,  B01D9/0054 ,  B01D9/0081

摘要： A crystalline material sufficiently pure for use in pharmaceuticals may be made by forming a saturated solution of the material changing the temperature of the solution so it becomes supersaturated, and briefly subjecting the solution to irradiation by high intensity ultrasound, before allowing the solution to cool gradually without further irradiation. The ultrasound may be applied using a vessel with an array of ultrasonic transducers attached to a wall, so each transducer radiates no more than 3 W/cm2 yet the power dissipation within the vessel is between 25 and 150 W/litre. This method can reduce the metastable zone width to less than 10 K. There is no erosion of the wall and consequently no formation of small particles of metal. It is applicable for example to aspartame, and to amino acids.

摘要翻译： 用于药物的足够纯的结晶物质可以通过形成改变溶液温度的材料的饱和溶液使其变得过饱和，并且在使溶液逐渐冷却之前将溶液短暂地经过高强度超声波照射， 无需进一步照射。 可以使用具有附接到壁的超声波换能器阵列的血管来应用超声波，因此每个换能器辐射不超过3W / cm 2，而容器内的功率耗散在25和150之间 W /升。 这种方法可以将亚稳区宽度减小到小于10K。没有壁的侵蚀，因此没有形成小的金属颗粒。 它适用于例如阿斯巴甜和氨基酸。