公开(公告)号：US5266561A

公开(公告)日：1993-11-30

申请号：US715302

申请日：1991-06-04

申请人： Garth J. S. Cooper ,  Howard Greene, Jr.

发明人： Garth J. S. Cooper ,  Howard Greene, Jr.

IPC分类号： A61K38/00 ,  A61P3/10 ,  C07K14/575 ,  C07K16/26 ,  C61K37/02 ,  C07K7/06 ,  C07K7/08 ,  C07K7/10

CPC分类号： C07K16/26 ,  C07K14/575 ,  A61K38/00 ,  Y10S514/866

摘要： Compounds and methods for blocking the effects of diabetes-associated peptide, or "amylin", a hormone found in the amyloid masses of Type 2 diabetics. This putative hormone has been discovered to function both to inhibit insulin secretion and to inhibit glycogen synthesis. Regulation is accomplished by blocking the binding of amylin or amylin agonists, including calcitonin gene related peptide (CGRP], or biologically active sub-peptides thereof. Inhibitors include substituted peptides or sub-peptides of amylin or CGRP, cross-linked amylin and amylin agonists, synthetic amylin, anti-amylin receptor antibodies and anti-idiotype antibodies, and antibodies directed to amylin and amylin agonist active sites. Other antagonists include organic compounds which can be screened and assayed for anti-amylin effects by disclosed methods.

摘要翻译： 用于阻断糖尿病相关肽或“胰岛淀粉样多肽”的作用的化合物和方法，其是在2型糖尿病患者的淀粉样蛋白质中发现的激素。 已经发现这种推定的激素既能抑制胰岛素分泌又抑制糖原合成。 调节是通过阻断胰岛淀粉样多肽或胰岛淀粉样多肽激动剂（包括降钙素基因相关肽（CGRP）或其生物活性亚肽）的结合来实现的。抑制剂包括取代的肽或胰岛淀粉样多肽或CGRP的亚肽，交联的胰岛淀粉样多肽和胰岛淀粉样多肽激动剂 ，合成的胰岛淀粉样多肽，抗胰岛淀粉样多肽受体抗体和抗独特型抗体，以及针对胰岛淀粉样多肽和胰岛淀粉样多肽激动剂活性位点的抗体。其它拮抗剂包括通过公开的方法可筛选和测定抗胰淀素作用的有机化合物。