公开(公告)号：WO2023287825A1

公开(公告)日：2023-01-19

申请号：PCT/US2022/036872

申请日：2022-07-12

Applicant: DIGNITY HEALTH

Inventor： BENET, Arnau ,  GRAHAM, Dakota

IPC: A61B17/32

Abstract: A system for inserting a medical tube within the body using a tunneler device enables formation of a tunnel within the body and further enables concurrent insertion of the medical tube within the body as the tunnel is formed, eliminating extra steps required by current technologies for insertion of the medical tube within the body. The tunneler device provides an attachment element that captures the medical tube and further provides a handle slidably mounted along the tunneler device to aid practitioners when inserting the tunneler device into the body. The tunneler device further provides a bend angle to aid practitioners in forming the tunnel past the clavicle of the body. The tunneler device enables practitioners to place medical tubes within the body while reducing time and friction commonly associated with medical tube placement procedures.

公开(公告)号：WO2023279110A1

公开(公告)日：2023-01-05

申请号：PCT/US2022/073392

申请日：2022-07-01

Applicant: DIGNITY HEALTH ,  BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY ,  VAN ANDEL RESEARCH INSTITUTE

Inventor： MANFREDSSON, Fredric ,  BRUNDIN, Lena

IPC: C12N15/52 ,  A61K38/51 ,  A61K48/00 ,  C12N9/88 ,  C12N15/113 ,  C12N15/86 ,  C12N15/861

Abstract: Compositions for increasing the expression of ACMSD in a target cell and methods of using the compositions to provide a general protective effect in a cell or tissue in a subject, or protect a subject from or treating a disease condition associated with inflammation, oxidative stress, protein aggregation, energy failure, toxic exposure such as exposure to pollutants, or any combination thereof.

公开(公告)号：WO2022081999A1

公开(公告)日：2022-04-21

申请号：PCT/US2021/055218

申请日：2021-10-15

Applicant: DIGNITY HEALTH

Inventor： COLE, Tyler ,  GRAHAM, Dakota

IPC: A61B17/11 ,  A61B17/00 ,  A61B17/04 ,  A61B17/115

Abstract: Various embodiments of a device for deep surgical corridor microvascular anastomosis are described herein. A device, comprising: an elongated body; a rod disposed at least partially within the channel of the elongated body; an actuator in association with the elongated body and the rod, wherein the actuator is operable to actuate the rod in a first axial direction; and a pair of coupling arms in association with the distal portion of the rod, wherein the actuator is operable to actuate the rod in a first axial direction such that the pivotable end of each coupling arm of the pair of coupling arms is consequently actuated in the first axial direction such that the pair of coupling arms are parallel with one another in a closed configuration.

公开(公告)号：WO2022056221A1

公开(公告)日：2022-03-17

申请号：PCT/US2021/049804

申请日：2021-09-10

Applicant: DIGNITY HEALTH ,  ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： HOULIHAN, Lena, Mary ,  NAUGHTON, David ,  PREUL, Mark, C.

IPC: A61G13/00 ,  G09B23/00

Abstract: Various embodiments of a system and associated method for determining a volume of surgical freedom using a plurality of three-dimensional extrema points along a surgical corridor in relation to a structure of interest are disclosed herein.

公开(公告)号：WO2021230871A1

公开(公告)日：2021-11-18

申请号：PCT/US2020/032845

申请日：2020-05-14

Applicant: DIGNITY HEALTH

Inventor： BOHL, Michael

IPC: A61B17/02 ,  A61B17/56 ,  A61B17/58 ,  A61B17/66 ,  A61B17/70 ,  A61B17/90

Abstract: Various embodiments of an anchor and intradiscal implant for surgical realignment of a misaligned spine are disclosed herein.

公开(公告)号：WO2021226389A2

公开(公告)日：2021-11-11

申请号：PCT/US2021/031167

申请日：2021-05-06

Applicant: DIGNITY HEALTH ,  BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY

Inventor： MANFREDSSON, Fredric ,  STEECE-COLLIER, Kathy

IPC: C12Q1/6886 ,  C07K14/705 ,  C12N15/113 ,  A61K31/713 ,  G16B25/00 ,  C12N15/1138 ,  C12N15/86 ,  C12N2310/14 ,  C12N2750/14143

Abstract: Disclosed are systems and compositions for reducing the expression of a CaV1.3 protein in a subject and methods of using the systems for treating dyskinesias induced by DA agonist therapy including levodopa-induced dyskinesias (LID), improving the response to levodopa, and improving the response to levodopa in a subject in need thereof; and slowing progression of Parkinson's disease by providing protection against death or dysfunction of substantia nigra dopamine neurons.

公开(公告)号：WO2020092847A1

公开(公告)日：2020-05-07

申请号：PCT/US2019/059270

申请日：2019-10-31

Applicant: DIGNITY HEALTH

Inventor： BOHL, Michael A.

IPC: A61B17/68 ,  A61B17/70 ,  A61B17/80 ,  A61B17/86 ,  A61B17/88 ,  A61F2/30 ,  A61F2/32

Abstract: The present disclosure generally relates to a sacroiliac joint coupler having a base plate and an angled plate for respective engagement with the sacrum and ilium are described herein. The sacroiliac joint coupler includes a bolt having a threaded distal end extending from a top face of the base plate and a fastener that couples the distal end of the bolt to the angled plate. In addition, the fastener may include a hinge or a locking ball.

公开(公告)号：WO2019165472A1

公开(公告)日：2019-08-29

申请号：PCT/US2019/019671

申请日：2019-02-26

Applicant: DIGNITY HEALTH

Inventor： BOWSER, Robert ,  VU, Lucas

IPC: A61K38/00 ,  A61K38/08 ,  C12Q1/68

Abstract: The present disclosure describes methods of determining a treatment protocol for and/or a prognosis for a subject suspected of or at risk of suffering from a neurologic disease or disorder, including such diseases and disorders that involve motor neuron function. In certain aspects, methods are provided for determining a concentration of a one or more chitinase proteins in a biological fluid sample containing or suspected of containing chitinase protein.

公开(公告)号：WO2018195043A1

公开(公告)日：2018-10-25

申请号：PCT/US2018/027916

申请日：2018-04-17

Applicant: DIGNITY HEALTH ,  ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： GARCIA, Antonio ,  LIEBERMAN, Abraham

IPC: G01N30/72 ,  G01N33/487

Abstract: Apparatus and methods for measuring a concentration of a target molecule from a biological sample are disclosed. For example, the apparatus comprises a porous pad, which is impregnated with a solution containing at least one agent and contains an unfilled capillary matrix, a housing for the porous pad, and a membrane that covers the porous pad.

公开(公告)号：WO2018098337A1

公开(公告)日：2018-05-31

申请号：PCT/US2017/063088

申请日：2017-11-22

Applicant: DIGNITY HEALTH

Inventor： BOHL, Michael ,  HANZE, Zachary ,  BAUMANN, Kevin ,  POTTINGER, Megan ,  XU, David

IPC: A61B17/02 ,  A61M27/00

Abstract: Various embodiments of a non-metal retractor device for retracting an incision and retaining a shunt are described herein.