公开(公告)号：WO2019169152A1

公开(公告)日：2019-09-06

申请号：PCT/US2019/020084

申请日：2019-02-28

申请人： NOUREDDINE, Achraf ,  BRINKER, Charles Jeffrey ,  HJELVIK, Elizabeth

发明人： NOUREDDINE, Achraf ,  BRINKER, Charles Jeffrey ,  HJELVIK, Elizabeth

IPC分类号： A61K9/51 ,  A61K9/14 ,  A61K47/04 ,  B82Y5/00 ,  B82Y40/00

摘要： The present disclosure is directed to methods of producing star-like mesoporous silica nanoparticles (SMSNPs) and protocells SMSNPs and their use for targeted drug delivery formulations and systems and for biomedical applications. Also provided are methods of producing monosized protocells from monodisperse SMSNPs and their use for targeted drug delivery formulations and systems and for biomedical applications.

公开(公告)号：WO2021202458A1

公开(公告)日：2021-10-07

申请号：PCT/US2021/024788

申请日：2021-03-30

申请人： UNM RAINFOREST INNOVATIONS ,  SERDA, Rita E. ,  GUO, Jimin ,  NOUREDDINE, Achraf ,  FRANCO, Stefan A. ,  DEMAY, Henning

发明人： SERDA, Rita E. ,  GUO, Jimin ,  NOUREDDINE, Achraf ,  FRANCO, Stefan A. ,  DEMAY, Henning

IPC分类号： C01B33/12 ,  A61K9/14 ,  A61K33/00 ,  A61K45/06 ,  B82B1/00 ,  B82Y5/00 ,  A61P35/00

摘要： A mesoporous silica nanoparticle includes a plurality of pores, a bioactive agent disposed in at least a portion of the pores, and an immunomodulatory moiety either disposed in a portion of the pores or bound to at least a portion of the outer surface of the nanoparticle.

公开(公告)号：WO2021202449A1

公开(公告)日：2021-10-07

申请号：PCT/US2021/024776

申请日：2021-03-30

申请人： UNM RAINFOREST INNOVATIONS ,  SERDA, Rita E. ,  GUO, Jimin ,  NOUREDDINE, Achraf ,  FRANCO, Stefan A. ,  DEMAY, Henning

发明人： SERDA, Rita E. ,  GUO, Jimin ,  NOUREDDINE, Achraf ,  FRANCO, Stefan A. ,  DEMAY, Henning

IPC分类号： A61K35/13 ,  A61K35/74 ,  A61K35/76 ,  A61K9/14 ,  C12N5/09 ,  C12N5/073 ,  C12N1/20 ,  C12N7/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  B82Y5/00

摘要： A silicified cell includes a nanoparticle that carries a bioactive agent. The silicified call can be a tumor cell, a bacterial cell, a virus, or a silicifiable compartment or fragment thereof. The silicified cell can optionally include an immunomodulatory moiety that may be carried within pores of the nanoparticle and/or bound to the surface of the nanoparticle. The silicified call can be used as a prophylactic or therapeutic treatment for treating tumors or bacterial infections.

公开(公告)号：WO2019173391A1

公开(公告)日：2019-09-12

申请号：PCT/US2019/020824

申请日：2019-03-05

申请人： SERDA, Rita Elena ,  NOUREDDINE, Achraf

发明人： SERDA, Rita Elena ,  NOUREDDINE, Achraf

IPC分类号： A61K31/704 ,  A61K31/739 ,  A61K38/17 ,  A61K47/02 ,  A61P37/02 ,  A61P35/00 ,  B82Y5/00

摘要： Compositions comprising, and methods of using, mesoporous hybrid siliceous nanoparticles comprising a TLR ligand or other immune stimulant(s), and an agent to induce immunogenic cell death.