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公开(公告)号：WO2017035009A1
公开(公告)日：2017-03-02
申请号：PCT/US2016/047851
申请日：2016-08-19
CPC分类号： C07K17/02 , A61K9/1272
摘要： Disclosed are positively-charged, cytotoxic nanoparticle compositions comprising immune modulators (such as the toll-like receptor (TLR)-4 ligand, monophosphoryl lipid (MPL)-A), and Interleukin (IL)-12)), which exhibit enhanced uptake by mammalian cancer cells, and cause increased cancer cell death and/or an increased release of cancer antigens following direct injection to populations of cancer or tumor cells. Also disclosed are nanoparticle-vectored, immunomodulatory compositions that stimulate antigen presenting immune cells and T cells, and support the development of anti-cancer immunity in mammalian hosts. The disclosed cationic liposomes represent an important advance in the area of cancer immunotherapeutics.
摘要翻译： 公开了包含免疫调节剂（例如toll样受体（TLR）-4配体，单磷酰脂肪（MPL）-A）和白细胞介素（IL）-12））的带正电荷的细胞毒性纳米颗粒组合物，其表现出增强的摄取 并且直接注射到癌症或肿瘤细胞群体后引起癌细胞死亡增加和/或增加的癌抗原释放。 还公开了刺激抗原呈递免疫细胞和T细胞的纳米粒子向量的免疫调节组合物，并且支持哺乳动物宿主中抗癌免疫的发展。 所公开的阳离子脂质体是癌症免疫治疗领域的重要进步。
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公开(公告)号：WO2019028387A1
公开(公告)日：2019-02-07
申请号：PCT/US2018/045218
申请日：2018-08-03
CPC分类号： A61P35/00 , A61K9/127 , A61K9/5123 , A61K39/39 , A61K2039/55555 , A61K2039/55572 , A61K2039/572 , A61K2039/6018 , A61P37/00 , B82Y5/00
摘要： The present disclosure is directed to methods of producing lipid coated nanoparticles useful for biomedical applications, e.g., vaccines, adjuvants. The present disclosure is also directed in part to, e.g., multilamellar or unilamellar, protocell vaccines.
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公开(公告)号：WO2019173391A1
公开(公告)日：2019-09-12
申请号：PCT/US2019/020824
申请日：2019-03-05
IPC分类号： A61K31/704 , A61K31/739 , A61K38/17 , A61K47/02 , A61P37/02 , A61P35/00 , B82Y5/00
摘要： Compositions comprising, and methods of using, mesoporous hybrid siliceous nanoparticles comprising a TLR ligand or other immune stimulant(s), and an agent to induce immunogenic cell death.
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