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1.发明申请
公开(公告)号：WO2022031362A1
公开(公告)日：2022-02-10
申请号：PCT/US2021/036128
申请日：2021-06-07
Applicant: OJAI RETINAL TECHNOLOGY, LLC
Inventor： LUTTRULL, Jeffrey K. , CHANG, David B.
IPC: A61N1/40
Abstract: A protective therapy system for biological tissues or fluids includes applying a pulsed energy source to a target tissue or a target fluid having a chronic progressive disease or a risk of having a chronic progressive disease to therapeutically or prophylactically treat the target tissue or target fluid. A pulsed energy source having selected energy parameters may be applied to a brain of an individual who has Alzheimer's or other neurodegenerative disease or is at risk of developing such a neurodegenerative disease so as to prevent or treat the neurodegenerative disease.
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2.发明申请
公开(公告)号：WO2020112234A1
公开(公告)日：2020-06-04
申请号：PCT/US2019/053553
申请日：2019-09-27
Applicant: OJAI RETINAL TECHNOLOGY, LLC
Inventor： LUTTRULL, Jeffrey K. , CHANG, David B.
Abstract: A system and process for safely providing retinal phototherapy includes generating first and second light beams of a different wavelength. The first and second light beams are applied to a retinal pigment epithelium (RPE) (24) and choroid (26) of an eye (10). The amount of light reflected from the eye from the first light beam and the second light beam is measured, such as using a reflectometer (110). A level or concentration of the melanin within the eye is calculated using the measured amount of light reflected from the eye from the first and second light beams. When the content or density of melanin in the RPE exceeds a predetermined amount, one or more treatment parameters of the retinal phototherapy is adjusted.
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3.发明申请
公开(公告)号：WO2020112163A1
公开(公告)日：2020-06-04
申请号：PCT/US2019/029636
申请日：2019-04-29
Applicant: OJAI RETINAL TECHNOLOGY, LLC
Inventor： LUTTRULL, Jeffrey K. , CHANG, David B.
Abstract: A process for safely providing retinal phototherapy includes generating first and second light beams of a different wavelength. The first and second light beams are applied to a retinal pigment epithelium (RPE) and choroid of an eye The amount of light reflected from the eye from the first light beam and the second light beam is measured, such as using a reflectometer. A level or concentration of the melanin within the eye is calculated using the measured amount of light reflected from the eye from the first and second light beams. When the content or density of melanin in the RPE exceeds a predetermined amount, one or more treatment parameters of the retinal phototherapy is adjusted.
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公开(公告)号：WO2018169560A1
公开(公告)日：2018-09-20
申请号：PCT/US2017/044337
申请日：2017-07-28
Applicant: OJAI RETINAL TECHNOLOGY, LLC
Inventor： LUTTRULL, Jeffrey K. , CHANG, David B. , MARGOLIS, Benjamin W. L.
IPC: A61F9/008
CPC classification number: A61F9/008 , A61F2009/00863 , A61N1/403 , A61N5/025 , A61N5/0603 , A61N5/062 , A61N5/0625 , A61N7/00 , A61N7/02 , A61N2005/0608 , A61N2005/0609 , A61N2005/0648 , A61N2005/0659 , A61N2005/0662 , A61N2005/067
Abstract: A process for heat treating biological tissue includes applying a pulsed energy to a first treatment area of a target tissue to create a therapeutic effect to the target tissue without destroying or permanently damaging the target tissue. After a predetermined interval of time, within a single treatment session, the pulsed energy is reapplied to the first treatment area. During the interval of time between pulsed energy applications to the first treatment area, the pulsed energy is applied to a second treatment area of the target tissue that is spaced apart from the first treatment area. The pulsed energy is repeatedly applied to each of the areas to be treated until a predetermined number of applications to each area to be treated has been achieved.
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5.发明申请
公开(公告)号：WO2022260781A1
公开(公告)日：2022-12-15
申请号：PCT/US2022/027447
申请日：2022-05-03
Applicant: OJAI RETINAL TECHNOLOGY, LLC
Inventor： LUTTRULL, Jeffrey K.
IPC: A61F9/008
Abstract: At least one pulsed light beam is applied to eye tissue to raise the temperature of the eye tissue to photostimulate the tissue. The at least one light beam has parameters of wavelength, duty cycle, power and pulse train duration selected to achieve a therapeutic or prophylactic effect while not permanently damaging the eye tissue. The eye tissue photostimulation improves ocular health and function and slows or prevents disorders associated with a normally aging eye.
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Patent Agency Ranking
公开(公告)号：WO2019099068A1
公开(公告)日：2019-05-23
申请号：PCT/US2018/042833
申请日：2018-07-19
Applicant: OJAI RETINAL TECHNOLOGY, LLC
Inventor： LUTTRULL, Jeffrey K. , CHANG, David B. , MARGOLIS, Benjamin W. L.
Abstract: A process for heat treating biological tissue includes generating treatment radiation having a predetermined wavelength and average power. The treatment radiation is applied to biological tissue, such as retinal tissue, such that at least one treatment spot is formed on the biological tissue and the biological tissue is heat stimulated sufficiently to create a therapeutic effect without destroying the tissue.
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公开(公告)号：WO2018169969A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/022201
申请日：2018-03-13
Applicant: OJAI RETINAL TECHNOLOGY, LLC
Inventor： LUTTRULL, Jeffrey K. , CHANG, David B. , MARGOLIS, Benjamin W. L.
IPC: A61N7/02
Abstract: A process for heat treating biological tissue includes repeatedly applying a pulsed energy to a target tissue over a period of time so as to controllably raise a temperature of the target tissue to create a therapeutic effect to the target tissue without destroying or permanently damaging the target tissue. After the first treatment is concluded the application of the pulsed energy to the target tissue is halted for an interval of time. Within a single treatment session a second treatment is performed on the target tissue after the interval of time by repeatedly reapplying the pulsed energy to the target tissue so as to controllably raise the temperature of the target tissue to therapeutically treat the target tissue without destroying or permanently damaging the target tissue.
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公开(公告)号：WO2017069819A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/042200
申请日：2016-07-14
Applicant: OJAI RETINAL TECHNOLOGY, LLC
Inventor： LUTTRULL, Jeffrey K. , BENJAMIN W. L., Margolis , CHANG, David B.
IPC: A61F9/008
CPC classification number: A61F9/00821 , A61F2009/00863
Abstract: A process for performing retinal phototherapy or photostimulation includes generating a laser light that creates a therapeutic effect to retinal and/or foveal tissues exposed to the laser light without destroying or permanently damaging the retinal or foveal tissue. The laser light is applied to a first treatment area of the retina. After a predetermined interval of time, within a single treatment session, the laser light is reapplied to the first treatment area of the retina. During the interval of time between the laser light applications to the first treatment area, the laser light is applied to one or more additional areas of the retina that is spaced apart from the first treatment area and one another. The laser light is repeatedly applied to each of the areas to be treated until a predetermined number of laser light applications to each area to be treated has been achieved.
Abstract translation:
一种用于执行视网膜光疗或光刺激过程包括生成用于创建到暴露于激光光视网膜和/或视网膜中央凹的组织而不会破坏或永久损坏视网膜中央凹或组织中的治疗效果的激光。 激光被施加到视网膜的第一治疗区域。 在预定的时间间隔之后，在单次治疗期间内，将激光重新施加到视网膜的第一治疗区域。 在激光施加到第一治疗区域之间的时间间隔期间，将激光施加到视网膜的与第一治疗区域间隔开的一个或多个另外的区域并且彼此相邻。 将激光重复施加到每个待处理区域，直到已经达到预定数量的激光照射到每个待处理区域为止。
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公开(公告)号：WO2019177654A1
公开(公告)日：2019-09-19
申请号：PCT/US2018/042903
申请日：2018-07-19
Applicant: OJAI RETINAL TECHNOLOGY, LLC
Inventor： LUTTRULL, Jeffrey, K. , CHANG, David, B. , MARGOLIS, Benjamin W., L.
Abstract: A process for heat treating biological tissue includes providing a plurality of energy emitters formed into an array. Treatment energy is generated from the plurality of emitters and applied to target tissue. The treatment energy has energy and application parameters selected so as to raise the target tissue temperature sufficiently to create a therapeutic effect while maintaining an average temperature of the target tissue over several minutes at or below a predetermined temperature so as not to destroy or permanently damage the target tissue.
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公开(公告)号：WO2017192168A1
公开(公告)日：2017-11-09
申请号：PCT/US2016/062421
申请日：2016-11-17
Applicant: OJAI RETINAL TECHNOLOGY, LLC
Inventor： LUTTRULL, Jeffrey K. , MARGOLIS, Benjamin W. L. , CHANG, David B.
IPC: A61F9/008
Abstract: Providing neuroprotective therapy for glaucoma includes generating a micropulsed laser light beam having parameters and characteristics, including pulse length, power, and duty cycle, selected to create a therapeutic effect with no visible laser lesions or tissue damage to the retina. The laser light beam is applied to retinal and/or foveal tissue of an eye having glaucoma or a risk of glaucoma to create a therapeutic effect to the retinal and/or foveal tissue exposed to the laser light beam without destroying or permanently damaging the retinal and/or foveal tissue and improve function or condition of an optic nerve and/or retinal ganglion cells of the eye.
Abstract translation: 为青光眼提供神经保护疗法包括产生具有参数和特征（包括脉冲长度，功率和占空比）的微脉冲激光束，所述微脉冲激光光束被选择以产生治疗效果，而没有可见的激光损伤或组织损伤 视网膜。 将激光束施加到患有青光眼或具有青光眼风险的眼睛的视网膜和/或中心凹组织，以对暴露于激光束的视网膜和/或中心凹组织产生治疗效果而不破坏或永久损伤视网膜和 /或中心凹组织并且改善眼睛的视神经和/或视网膜神经节细胞的功能或状况。
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