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    TRANSESOPHAGEAL IMPLANTATION OF CARDIAC ELECTRODES
    2.
    发明申请
    TRANSESOPHAGEAL IMPLANTATION OF CARDIAC ELECTRODES 审中-公开
    心脏电极的透视植入

    公开(公告)号：WO2007149588A3

    公开(公告)日：2008-09-12

    申请号：PCT/US2007014715

    申请日：2007-06-25

    Applicant: BELSON AMIR

    Inventor： BELSON AMIR

    IPC: A61N1/00

    CPC classification number: A61N1/0587 ,  A61B18/1492 ,  A61M5/00 ,  A61N1/0517 ,  A61N1/37205 ,  A61N1/375 ,  A61N5/0601 ,  A61N5/1002 ,  A61N2005/0609 ,  A61N2005/063 ,  A61N2005/0652

    Abstract: The present invention provides for transesophageal implantation of cardiac electrodes (102) and (104) for pacing and/or defibrillation The electronic module (110) could be implanted in the abdomen or thorax using a transesophageal, transgatric, thoracoscopic or open surgical approach In another aspect, the invention provides for transesophageal delivery of other cardiac therapies including ablation, phototherapy, radiation therapy and implantation or injection of therapeutic substances into the heart The transesophageal approach takes advantage of the proximity between the esophagus and the chambers of the heart, allowing surgical access to the heart with very low morbidity and risk of complications.

    Abstract translation: 本发明提供用于起搏和/或除颤的心脏电极（102）和（104）的经食管植入。电子模块（110）可以使用经食管，经皮，胸腔镜或开放手术方法植入腹部或胸部。另一方面 方面，本发明提供了其他心脏治疗的经食管递送，包括消融，光疗，放射治疗以及将治疗物质注入或注入心脏。经食管方法利用了食道和心脏室之间的接近，允许外科手术 心脏发病率低，发生并发症的风险很高。

    DILATATION BALLOON CATHETER INCLUDING EXTERNAL MEANS FOR ENDOLUMINAL THERAPY AND FOR DRUG ACTIVATION
    5.
    发明申请
    DILATATION BALLOON CATHETER INCLUDING EXTERNAL MEANS FOR ENDOLUMINAL THERAPY AND FOR DRUG ACTIVATION 审中-公开
    放射性气囊导管，包括内分泌治疗和药物启动的外部手段

    公开(公告)号：WO2005081633A3

    公开(公告)日：2005-11-10

    申请号：PCT/IL2005000234

    申请日：2005-02-27

    Applicant: SEGALESCU VICTOR A ,  BARTAL GABRIEL

    Inventor： SEGALESCU VICTOR A ,  BARTAL GABRIEL

    IPC: A61B18/18 ,  A61F2/958 ,  A61M29/02

    CPC classification number: A61M25/1002 ,  A61B2017/22051 ,  A61M25/104 ,  A61M2025/1004 ,  A61M2025/1086 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0609 ,  A61N2005/061 ,  A61N2005/0611

    Abstract: An inflatable device to be used in treatment of stenotic lesions includes external optical fibers with a segment capable of emitting substantially uniform radial energy. The design of the optical fibers ensures a high optical coupling factor and a high efficiency in delivering light-energy to the adjacent tissue volume. A light source is connected to the optical fibers during the inflation of the device. The parameters of the light source: wavelength, waveform and intensity and the design of the optical fibers ensure that the light-tissue interaction depth is within a thin layer of stenotic lesion without inducing irreversible damage to the vessel wall. During the inflation of the device, the external optical fibers pressure the same tissue volume that interacted with the radial emitted light-energy. The confined radial light energy and the mechanical effects induced by the optical fibers create an opto-mechanical effect that facilitates the dilatation of stenotic lesions and reduces the risk of restenosis. The external optical fibers can also facilitate endoluminal drug activation, wherein light activated drugs are used to prevent restenosis or to treat cardiovascular, system, benign and malignant stenosis and other diseases. Various combinations of optical fibers with different capabilities can be used in the same device. The device can be used in treatment of stenosis in the vascular system and in non-vascular systems (such as the urinary or biliary systems). The design of the device ensures that the attachment of the external optical fibers does not obstruct the advancement and maneuvering of the device through tortuous anatomical structures such as stenotic or partially occluded blood vessels.

    Abstract translation: 用于治疗狭窄病变的充气装置包括具有能够发射基本均匀的径向能量的部分的外部光纤。 光纤的设计确保了高的光学耦合因子，并且将光能传递到相邻组织体积的高效率。 在设备充气期间，光源连接到光纤。 光源的参数：波长，波形和强度以及光纤的设计确保光组织相互作用深度在狭窄的狭窄层内，而不会对血管壁造成不可逆的损伤。 在装置的充气期间，外部光纤压力与径向发射的光能相互作用的相同组织体积。 限制的径向光能和由光纤引起的机械效应产生光学机械效应，其有助于狭窄病变的扩张并降低再狭窄的风险。 外部光纤还可以促进腔内药物活化，其中使用光活化药物来预防再狭窄或治疗心血管系统，良性和恶性狭窄等疾病。 具有不同能力的光纤的各种组合可用于同一设备。 该装置可用于治疗血管系统和非血管系统（如尿液或胆道系统）的狭窄。 该设备的设计确保外部光纤的连接不会妨碍通过曲折解剖结构（例如狭窄或部分闭塞的血管）的装置的前进和操纵。

    DILATATION BALLOON CATHETER INCLUDING EXTERNAL MEANS FOR ENDOLUMINAL THERAPY AND FOR DRUG ACTIVATION
    6.
    发明申请
    DILATATION BALLOON CATHETER INCLUDING EXTERNAL MEANS FOR ENDOLUMINAL THERAPY AND FOR DRUG ACTIVATION 审中-公开
    扩张球囊导管包括用于内窥镜治疗和药物激活的外部手段

    公开(公告)号：WO2005081633A2

    公开(公告)日：2005-09-09

    申请号：PCT/IL2005/000234

    申请日：2005-02-27

    Applicant: SEGALESCU, Victor, A. ,  BARTAL, Gabriel

    Inventor： SEGALESCU, Victor, A. ,  BARTAL, Gabriel

    IPC: A61B18/18 ,  A61F2/958 ,  A61M29/02

    CPC classification number: A61M25/1002 ,  A61B2017/22051 ,  A61M25/104 ,  A61M2025/1004 ,  A61M2025/1086 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0609 ,  A61N2005/061 ,  A61N2005/0611

    Abstract: An inflatable device to be used in treatment of stenotic lesions includes external optical fibers with a segment capable of emitting substantially uniform radial energy. The design of the optical fibers ensures a high optical coupling factor and a high efficiency in delivering light-energy to the adjacent tissue volume. A light source is connected to the optical fibers during the inflation of the device. The parameters of the light source: wavelength, waveform and intensity and the design of the optical fibers ensure that the light-tissue interaction depth is within a thin layer of stenotic lesion without inducing irreversible damage to the vessel wall. During the inflation of the device, the external optical fibers pressure the same tissue volume that interacted with the radial emitted light-energy. The confined radial light energy and the mechanical effects induced by the optical fibers create an opto-mechanical effect that facilitates the dilatation of stenotic lesions and reduces the risk of restenosis. The external optical fibers can also facilitate endoluminal drug activation, wherein light activated drugs are used to prevent restenosis or to treat cardiovascular, system, benign and malignant stenosis and other diseases. Various combinations of optical fibers with different capabilities can be used in the same device. The device can be used in treatment of stenosis in the vascular system and in non-vascular systems (such as the urinary or biliary systems). The design of the device ensures that the attachment of the external optical fibers does not obstruct the advancement and maneuvering of the device through tortuous anatomical structures such as stenotic or partially occluded blood vessels.

    Abstract translation: 用于治疗狭窄病变的可充气装置包括具有能够发射基本均匀径向能量的节段的外部光纤。 光纤的设计确保高光耦合因子和高效的光能传递给相邻的组织体积。 在装置充气期间光源连接到光纤。 光源的参数：波长，波形和强度以及光纤的设计确保光 - 组织相互作用深度位于狭窄损伤薄层内，而不会对血管壁造成不可逆损伤。 在装置充气期间，外部光纤压迫与径向发射的光能相互作用的相同组织体积。 受限的径向光能和由光纤引起的机械效应产生光机械效应，促进狭窄病变的扩张并降低再狭窄的风险。 外部光纤也可以促进腔内药物活化，其中光活化药物用于预防再狭窄或治疗心血管系统，良性和恶性狭窄以及其他疾病。 具有不同能力的光纤的各种组合可以用于相同的设备中。 该装置可用于治疗血管系统和非血管系统（如泌尿系统或胆系统）的狭窄。 该设备的设计确保了外部光纤的连接不会通过曲折的解剖结构，如狭窄或部分闭塞的血管阻碍设备的前进和操纵。

    TREATMENT FOR EPITHELIAL DISEASES
    7.
    发明申请
    TREATMENT FOR EPITHELIAL DISEASES 审中-公开
    治疗上皮疾病

    公开(公告)号：WO02007630A1

    公开(公告)日：2002-01-31

    申请号：PCT/US2001/022701

    申请日：2001-07-19

    IPC: A61B17/22 ,  A61B18/00 ,  A61B18/22 ,  A61N5/06 ,  A61B18/18

    CPC classification number: A61N5/062 ,  A61B18/22 ,  A61B2017/22054 ,  A61B2018/00982 ,  A61B2018/2261 ,  A61N5/0601 ,  A61N2005/0609

    Abstract: An apparatus and method for treating epithelial hyperproliferative diseases by application of an active composition over the diseased irregular tissue which is in the form of a viscous gel to carry the photosensitizer. The gel's viscosity allows it to adhere to the tissue for a sufficient time to transfer the photosensitizer or for a mechanical device such an expanding balloon to press the gel into the tissue. The photosensitizer within the gel is activated by the corresponding wavelenght of radiation. An extended multi-ballon system limits the area of treatment and localizes the spread of the gel. The apparatus, designed to be used with an endoscope, contains a catheter with at least two balloons, one to block drainage of the gel and one to limit the height of the treatment area and to press the gelinto the tissue.

    Abstract translation: 一种用于通过将活性组合物施用在呈粘性凝胶形式的病态不规则组织上以携带光敏剂来治疗上皮过度增殖性疾病的装置和方法。 凝胶的粘度允许其粘附到组织足够的时间以转移光敏剂或用于机械装置如膨胀气囊将凝胶压入组织。 凝胶内的光敏剂被相应的辐射波长激活。 扩展的多气囊系统限制了治疗面积，并定位了凝胶的扩散。 设计为与内窥镜一起使用的装置包含具有至少两个气囊的导管，一个用于阻止凝胶的引流，一个限制治疗区域的高度并将凝胶压入组织。

    NONINVASIVE VASCULAR THERAPY
    8.
    发明申请
    NONINVASIVE VASCULAR THERAPY 审中-公开
    无创血管治疗

    公开(公告)号：WO0041726A2

    公开(公告)日：2000-07-20

    申请号：PCT/US0000852

    申请日：2000-01-14

    Applicant: LIGHT SCIENCES LTD ,  CHEN JAMES

    Inventor： CHEN JAMES

    IPC: A61N5/06 ,  A61D7/00 ,  A61K31/197 ,  A61K31/404 ,  A61K31/5415 ,  A61K31/609 ,  A61K39/395 ,  A61K41/00 ,  A61P9/10 ,  A61P35/00 ,  A61P43/00

    CPC classification number: A61N5/062 ,  A61B18/1815 ,  A61B2090/378 ,  A61K41/0057 ,  A61K41/0071 ,  A61N5/0601 ,  A61N2005/0602 ,  A61N2005/0604 ,  A61N2005/0609 ,  A61N2005/0651 ,  A61N2005/0659

    Abstract: The present invention is drawn to methods and compounds for transcutaneous photodynamic therapy ("PDT") of a target tissue or compositions in a mammalian subject, which includes administering to the subject a therapeutically effective amount of a photosensitizing agent or a photosensitizing agent delivery system or a prodrug, where the photosensitizing agent or photosensitizing agent delivery system or prodrug selectively binds to the target tissue; and irradiating at least a portion of the subject with light at a wavelength absorbed by the photosensitizing agent or if prodrug, by a prodrug product thereof, where the light is provided by a light source, and where the irradiation is at low fluence rate that results in the activation of the photosensitizing agent or prodrug product. These methods of transcutaneous PDT are useful in the treatment of specifically selected target tissues, such as: vascular endothelial tissue; abnormal vascular wall of tumors; tumors of the head and neck; tumors of the gastrointestinal tract; tumors of the liver; tumors of the esophopharyngeal; tumors of the lung; lymphoid tissue; lesions in the vascular system; bone marrow and tissue related to autoimmune disease.

    Abstract translation: 本发明涉及用于哺乳动物受试者中的目标组织或组合物的经皮光动力疗法（“PDT”）的方法和化合物，其包括向受试者施用治疗有效量的光敏剂或光敏剂递送系统或 前体药物，其中光敏剂或光敏剂递送系统或前药选择性地结合靶组织; 并且用由光敏剂吸收的波长的光照射至少一部分受试者，或者如果前药，由其前药产物照射，其中光由光源提供，并且其中照射的通量率低，结果 在光敏剂或前药产物的活化中。 这些经皮PDT方法可用于特异性选择的靶组织的治疗，例如：血管内皮组织; 肿瘤血管壁异常; 头部和颈部的肿瘤; 胃肠道肿瘤; 肝脏肿瘤; esophopharyngeal的肿瘤; 肺部肿瘤; 淋巴组织; 血管系统中的病变; 骨髓和与自身免疫疾病有关的组织。

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