公开(公告)号：WO2010004365A1

公开(公告)日：2010-01-14

申请号：PCT/IB2008/052787

申请日：2008-07-10

Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) ,  LASSER, Theo ,  VAN DE VILLE, Dimitri ,  MARTIN-WILLIAMS, Erica ,  LEUTENEGGER, Marcel ,  MAERKI, Iwan ,  FRIEDRICH, Michael ,  VILLIGER, Martin

Inventor： LASSER, Theo ,  VAN DE VILLE, Dimitri ,  MARTIN-WILLIAMS, Erica ,  LEUTENEGGER, Marcel ,  MAERKI, Iwan ,  FRIEDRICH, Michael ,  VILLIGER, Martin

IPC: A61B5/00 ,  A61B5/026 ,  A61B3/12

CPC classification number: A61B5/0066 ,  A61B3/102 ,  A61B3/1233 ,  A61B5/0048 ,  A61B5/0059 ,  A61B5/02028 ,  A61B5/413 ,  A61B5/7203 ,  A61B5/726 ,  A61B5/7278 ,  A61B5/742

Abstract: The present invention relates to a functional optical coherent imaging (fOCI) platform comprising at least one active camera unit (ACU) comprising a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOI). Further the invention relates to a process for acquiring stimuli activated subject data comprising the steps of aligning a body function unit at a subject and monitoring pre-selected body function; selecting a stimulus or stimuli; imaging a body area of interest; exerting one or a series of stimuli on the subject; imaging the body area of interest synchronous with said stimuli and the preselected body functions; and transferring said synchronized image, stimuli and body function data to a statistical analysis unit (SAU) and performing calculations to generate results pertaining to body functions.

Abstract translation: 功能性光学相干成像（fOCI）平台本发明涉及包括至少一个包括相干和/或部分相干光源的有源相机单元（ACU）的功能性光学相干成像（fOCI）平台，以及用于对感兴趣的所选择的身体区域进行频谱滤波和成像的装置; 用于预处理从ACU接收的数据的图像处理单元（IPU）; 向受试者传送刺激的至少一个刺激单元（STU）; 至少一个身体功能参考测量单元（BFMU）; 中央时钟和处理单元（CCU），与ACU，IPU，STU的互连，用于从IPU收集预处理的数据，以同步方式从BFMU的STU主体功能参考数据的刺激; 后处理单位（统计分析单位，SAU）; 和操作界面（HOI）。 此外，本发明涉及一种用于获取刺激激活的受试者数据的方法，包括以下步骤：对准受试者的身体功能单元并监测预先选择的身体功能; 选择刺激或刺激; 成像感兴趣的身体区域; 在该主题上施加一个或一系列刺激; 对与所述刺激同步的感兴趣的身体区域和预选的身体功能进行成像; 以及将所述同步图像，刺激和身体功能数据传送到统计分析单元（SAU）并执行计算以产生与身体功能有关的结果。

公开(公告)号：WO2008087613A3

公开(公告)日：2008-07-24

申请号：PCT/IB2008/050205

申请日：2008-01-21

Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) ,  LEITGEB, Rainer ,  BACHMANN, Adrian ,  VILLIGER, Martin ,  MICHAELY, Roland ,  LASSER, Theo

Inventor： LEITGEB, Rainer ,  BACHMANN, Adrian ,  VILLIGER, Martin ,  MICHAELY, Roland ,  LASSER, Theo

IPC: G01B9/02

Abstract: The present invention relates to an apparatus and a method combining achromatic complex FDOCT signal reconstruction with a common path and dual beam configuration. The complex signal reconstruction allows resolving the complex ambiguity of the Fourier transform and to enhance the achievable depth range by a factor of two. The dual beam configuration shares the property of high phase stability with common path FDOCT. This is of importance for a proper complex signal reconstruction and is in particular useful in combination with handheld probes such as in endoscopy and catheter applications. The advantages of the present invention are in particular the flexibility to choose arbitrarily positioned interfaces in the sample arm as reference together with the possibility to compensate for dispersion.

公开(公告)号：WO2011083420A3

公开(公告)日：2011-10-13

申请号：PCT/IB2011050020

申请日：2011-01-04

Applicant: ECOLE POLYTECH ,  VILLIGER MARTIN ,  PACHE CHRISTOPHE ,  LASSER THEO

Inventor： VILLIGER MARTIN ,  PACHE CHRISTOPHE ,  LASSER THEO

IPC: G02B21/12 ,  G01B9/02 ,  G01N21/47

CPC classification number: G02B21/125 ,  G01B9/02002 ,  G01B9/02057 ,  G01B9/02091 ,  G01B2290/50 ,  G01B2290/70 ,  G01J3/453

Abstract: The invention relates to an optical coherence microscopy system for fast, phase resolved imaging by means of optical coherence microscopy with decoupled illumination and detection apertures, producing a dark-field effect with an enhanced optical contrast. The setup uses a light source with an appropriate temporal coherence, an interferometer and an array detector combined with a spectrometer. The dark-field effect is produced by optical filter means in the illumination and detection paths, positioned in conjugated planes of the sample microscope objective. These optical means comprise for example refractive or diffractive elements, amplitude or phase masks, or programmable spatial light modulators. The object is scanned via a scanning unit allowing a point scan of the object.

Abstract translation: 本发明涉及一种光学相干显微术系统，用于借助光学相干显微镜（具有去耦合照明和检测孔径）的快速相位分辨成像，产生具有增强的光学对比度的暗场效应。 该设置使用具有适当时间相干性的光源，干涉仪和与光谱仪组合的阵列检测器。 暗场效应由照明和检测路径中的光学过滤装置产生，位于样品显微镜物镜的共轭平面中。 这些光学装置包括例如折射或衍射元件，振幅或相位掩模，或可编程空间光调制器。 物体通过扫描单元进行扫描，允许对物体进行点扫描。

公开(公告)号：WO2007085992A1

公开(公告)日：2007-08-02

申请号：PCT/IB2007/050195

申请日：2007-01-20

Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) ,  LEITGEB, Rainer ,  LASSER, Theo ,  BACHMANN, Adrian ,  STEINMANN, Lukas ,  VILLIGER, Martin

Inventor： LEITGEB, Rainer ,  LASSER, Theo ,  BACHMANN, Adrian ,  STEINMANN, Lukas ,  VILLIGER, Martin

IPC: G01N21/47

CPC classification number: G01N21/4795 ,  G01B9/02002 ,  G01B9/02035 ,  G01B9/02044 ,  G01B9/02091 ,  G01B2290/70

Abstract: The invention concerns an optical imaging apparatus comprising (o) a light source (1) , (p) sample holding means, (q) an interferometer, (r) reference means, (s) an objective (8) which is adapted to have its sample side focal plane crossing a sample held in said sample holding means, (t) optical or electro-optical means (2, 3, 5, 16) adapted to produce a ring shaped or multi-spot light source in the front focal plane (17) or any conjugated plane (17') of said objective (8) , at least one detector. The invention also includes a method for using said apparatus where the sample is illuminated by an interference pattern and the depth information is obtained by using optical Coherence Tomography.

Abstract translation: 本发明涉及一种光学成像设备，包括（o）光源（1），（p）样品保持装置，（q）干涉仪，（r）参考装置，（s）物镜（8） 其样品侧焦平面与保持在所述样品保持装置中的样品交叉;（t）适于在前焦平面中产生环形或多点光源的光学或电光装置（2,3,5,16） （17）或所述物镜（8）的任何共轭平面（17'），至少一个检测器。 本发明还包括使用所述装置的方法，其中样本被干涉图案照射，并且通过使用光学相干断层扫描获得深度信息。

公开(公告)号：WO2008087613A2

公开(公告)日：2008-07-24

申请号：PCT/IB2008050205

申请日：2008-01-21

Applicant: ECOLE POLYTECH ,  LEITGEB RAINER ,  BACHMANN ADRIAN ,  VILLIGER MARTIN ,  MICHAELY ROLAND ,  LASSER THEO

Inventor： LEITGEB RAINER ,  BACHMANN ADRIAN ,  VILLIGER MARTIN ,  MICHAELY ROLAND ,  LASSER THEO

IPC: G01B9/02

CPC classification number: G01N21/4795 ,  G01B9/02003 ,  G01B9/02044 ,  G01B9/02057 ,  G01B9/02069 ,  G01B9/02079 ,  G01B9/02091 ,  G01B2290/70

Abstract: The present invention relates to an apparatus and a method combining achromatic complex FDOCT signal reconstruction with a common path and dual beam configuration. The complex signal reconstruction allows resolving the complex ambiguity of the Fourier transform and to enhance the achievable depth range by a factor of two. The dual beam configuration shares the property of high phase stability with common path FDOCT. This is of importance for a proper complex signal reconstruction and is in particular useful in combination with handheld probes such as in endoscopy and catheter applications. The advantages of the present invention are in particular the flexibility to choose arbitrarily positioned interfaces in the sample arm as reference together with the possibility to compensate for dispersion.

Abstract translation: 本发明涉及将消色差复合FDOCT信号重建与公共路径和双光束配置组合的设备和方法。 复信号重构可以解决傅立叶变换的复杂模糊性，并将可实现的深度范围提高一倍。 双光束配置与普通路径FDOCT共享高相位稳定性。 这对于正确的复杂信号重建非常重要，特别适用于手持式探头，如内窥镜和导管应用。 本发明的优点特别在于选择样品臂中任意定位的界面作为参考的可能性以及补偿分散的可能性。

公开(公告)号：WO2011083420A2

公开(公告)日：2011-07-14

申请号：PCT/IB2011/050020

申请日：2011-01-04

Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) ,  VILLIGER, Martin ,  PACHE, Christophe ,  LASSER, Theo

Inventor： VILLIGER, Martin ,  PACHE, Christophe ,  LASSER, Theo

IPC: G02B21/12

CPC classification number: G02B21/125 ,  G01B9/02002 ,  G01B9/02057 ,  G01B9/02091 ,  G01B2290/50 ,  G01B2290/70 ,  G01J3/453

Abstract: The invention relates to an optical coherence microscopy system for fast, phase resolved imaging by means of optical coherence microscopy with decoupled illumination and detection apertures, producing a dark-field effect with an enhanced optical contrast. The setup uses a light source with an appropriate temporal coherence, an interferometer and an array detector combined with a spectrometer. The dark-field effect is produced by optical filter means in the illumination and detection paths, positioned in conjugated planes of the sample microscope objective. These optical means comprise for example refractive or diffractive elements, amplitude or phase masks, or programmable spatial light modulators. The object is scanned via a scanning unit allowing a point scan of the object.

Abstract translation: 本发明涉及通过具有解耦照明和检测孔径的光学相干显微镜进行快速，相位分辨成像的光学相干显微镜系统，产生具有增强的光学对比度的暗场效应。 该设置使用具有适当的时间相干性的光源，干涉仪和与光谱仪结合的阵列检测器。 暗场效应由位于样品显微镜物镜的共轭平面中的照明和检测路径中的滤光器装置产生。 这些光学装置包括例如折射或衍射元件，幅度或相位掩模或可编程空间光调制器。 通过允许对象的点扫描的扫描单元扫描物体。