专利检索 ap:("CEDARS-SINAI MEDICAL CENTER") AND inv:"KIM, Irene" 第 1 页

1.

发明申请
INTRA-RENAL INFUSIONS OF C1I INHIBITOR PRIOR TO TRANSPLANTATION OF ALLOGRAFTS TO REDUCE DELAYED GRAFT FUNCTION AND ISCHEMIA- REPERFUSION INJURY 审中-公开

公开(公告)号：WO2022140435A1

公开(公告)日：2022-06-30

申请号：PCT/US2021/064678

申请日：2021-12-21

申请人： CEDARS-SINAI MEDICAL CENTER

发明人： JORDAN, Stanley C. , AMMERMAN, Noriko , VO, Ashley , KIM, Irene , KUMAR, Sanjeev

IPC分类号： A61K38/57 , A61K47/02 , A61K47/12

摘要： The present invention describes method for reducing Delayed Graft Function (DGF) and Ischemia/Reperfusion Injury (IRI) by intra-renal infusion of a C1 esterase inhibitor.

2.

发明申请
USE OF CALCINEURIN INHIBITOR FREE CTLA4-IG + ANTI-IL6/IL6R FOR LONG TERM IMMUNOSUPPRESSION IN SOLID ORGAN TRANSPLANT RECIPIENTS 审中-公开

公开(公告)号：WO2021046361A1

公开(公告)日：2021-03-11

申请号：PCT/US2020/049422

申请日：2020-09-04

申请人： CEDARS-SINAI MEDICAL CENTER

发明人： JORDAN, Stanley, C. , VO, Ashley , AMMERMAN, Noriko , HUANG, Edmund , KIM, Irene

IPC分类号： C07K14/705 , C07K16/24 , C07K16/28

摘要： The present invention provides for methods and uses of (i) an IL-6 inhibitor or IL-6R inhibitor, or both; and (ii) CTLA-4 or CTLA-4 fusion proteins for immunosuppression and/or immunomodulation in a solid organ transplant recipient. Various embodiments of the method comprise administering an IL-6 inhibitor or IL-6R inhibitor, or both to the recipient; and administering a or CTLA-4 fusion protein such as CTLA4-Ig to the recipient and may further include administration or use of a calcineurin inhibitor.