公开(公告)号：WO2006060546A3

公开(公告)日：2006-07-13

申请号：PCT/US2005043425

申请日：2005-12-01

Applicant: COOK INC

Inventor： CASE BRIAN C ,  AGNEW CHARLES W

IPC: A61F2/24

CPC classification number: A61F2/2475 ,  A61F2/2418 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0026 ,  A61F2230/0067 ,  A61F2230/0095

Abstract: Medical devices (210) that provide valves for regulating fluid flow through a body vessel are provided. The venous valves include a support frame (216) having one or more adaptations (224) for forming a leak path (226) between the support frame (216) and an interior wall of a body vessel in which the valve is implanted. A controlled amount of retrograde flow is able to flow through the lead path (226) when the valve is implanted in a body vessel (280).

Abstract translation: 提供了提供用于调节通过身体容器的流体流动的阀的医疗装置（210）。 静脉瓣包括具有一个或多个适配件（224）的支撑框架（216），用于在支撑框架（216）和其中植入瓣膜的主体容器的内壁之间形成泄漏路径（226）。 当阀被植入身体容器（280）时，受控量的逆行流能够流过引导路径（226）。

公开(公告)号：WO2007016251A3

公开(公告)日：2008-04-03

申请号：PCT/US2006029209

申请日：2006-07-27

Applicant: COOK INC

Inventor： PURDY JAMES D JR ,  AGNEW CHARLES W ,  CASE BRIAN C ,  PAUL RAM H JR

IPC: A61L27/18 ,  A61L27/22 ,  A61L27/50 ,  A61L33/12

CPC classification number: A61F2/2412 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/2475 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61L27/18 ,  A61L27/227 ,  A61L27/507 ,  A61L33/12 ,  C08L75/04

Abstract: Medical devices for implantation within a body vessel comprising a thromboresistant material are provided. The thromboresistant material preferably comprises a biocompatible polyurethane, a remodelable material, a bioactive agent or any combination thereof. The medical device can be a prosthetic valve comprising a thromboresistant material. The medical device can also comprise a support frame with one or more valve leaflets attached to the support frame.

Abstract translation: 提供了用于植入包含抗血栓材料的体内容器内的医疗装置。 抗血栓材料优选包含生物相容性聚氨酯，可重塑材料，生物活性剂或其任何组合。 医疗装置可以是包含抗血栓材料的人造瓣膜。 医疗装置还可以包括具有连接到支撑框架的一个或多个瓣膜小叶的支撑框架。

公开(公告)号：WO2006113863A3

公开(公告)日：2007-09-27

申请号：PCT/US2006014864

申请日：2006-04-20

Applicant: COOK INC ,  PAL DHARMENDRA ,  AGNEW CHARLES W ,  FLAGLE JACOB A ,  LENTZ D CHRISTIAN ,  MELSHEIMER JEFFRY S ,  OSBORNE THOMAS A ,  PARKER FRED T

Inventor： PAL DHARMENDRA ,  AGNEW CHARLES W ,  FLAGLE JACOB A ,  LENTZ D CHRISTIAN ,  MELSHEIMER JEFFRY S ,  OSBORNE THOMAS A ,  PARKER FRED T

IPC: A61F2/84

CPC classification number: A61M25/0662 ,  A61F2/95 ,  A61F2002/9517 ,  A61M25/0045 ,  A61M25/005 ,  A61M25/0053

Abstract: Delivery systems for self-expanding devices are provided having a system proximal portion with a handle, an elongate middle section delivery device with an outer sheath and inner compression member, and a system distal portion including an outer guide channel member with first and second end portions defining a guide channel that slidably receives an inner guide channel member having a guide channel, the guide channels being substantially aligned. A mounting region for self-expanding devices is disposed radially between the inner and outer guide channel members. The outer guide channel member has a stepped profile from a first outer diameter to a second smaller outer diameter located near a transition region having a breech position opening for passage of a wire guide, catheter, or other medical instrument. The outer member is axially slideable relative to the inner member to deploy a self-expanding device. Methods of using and manufacturing are also provided.

Abstract translation: 提供了一种用于自扩张装置的输送系统，其具有带手柄的系统近端部分，具有外护套和内部压缩构件的细长中间部分输送装置，以及包括具有第一和第二端部的外部引导通道构件的系统远端部分 限定了可滑动地容纳具有引导通道的内部引导通道构件的引导通道，所述引导通道基本对齐。 用于自膨胀装置的安装区域径向地设置在内引导通道构件和外引导通道构件之间。 外引导通道构件具有从第一外径到第二较小外径的阶梯轮廓，位于具有用于导线器，导管或其他医疗器械通过的后膛位置开口的过渡区域附近。 外部构件相对于内部构件可轴向滑动以展开自扩张装置。 还提供了使用和制造方法。

公开(公告)号：WO2005099628A3

公开(公告)日：2005-12-08

申请号：PCT/US2005012421

申请日：2005-04-11

Applicant: COOK INC ,  CASE BRIAN C ,  FLAGLE JACOB A ,  AGNEW CHARLES W

Inventor： CASE BRIAN C ,  FLAGLE JACOB A ,  AGNEW CHARLES W

IPC: A61F2/00 ,  A61F2/02 ,  A61F2/24 ,  A61F2/86 ,  A61F2/90 ,  A61F2/06

CPC classification number: A61F2/86 ,  A61F2/07 ,  A61F2/2418 ,  A61F2/2475 ,  A61F2/848 ,  A61F2/89 ,  A61F2/90 ,  A61F2002/075 ,  A61F2210/0004 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0054 ,  A61F2250/0018 ,  A61F2250/0031 ,  A61F2250/0071

Abstract: Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. Embodiments of the invention relate to medical devices comprising a frame having a compliance that can change upon implantation of the medical device within the lumen of a body vessel. Controlled fracture of bioabsorption of frame material can, in some embodiments, increase the compliance of a frame after implantation. Medical devices comprising a frame and one or more valve members adapted to regulate fluid flow in a body vessel, such as a vein, are also provided.

Abstract translation: 提供了用于植入身体血管中的医疗设备，以及使用和制造该设备的方法。 本发明的实施例涉及医疗装置，其包括具有柔顺性的框架，所述柔顺性能够在将所述医疗装置植入身体血管的管腔内时改变。 在一些实施例中，框架材料的生物吸收的控制断裂可以在植入后增加框架的柔顺性。 还提供了包括框架和一个或多个阀构件的医疗装置，所述阀构件适于调节身体血管（例如静脉）中的流体流动。