公开(公告)号：WO2023091446A1

公开(公告)日：2023-05-25

申请号：PCT/US2022/050042

申请日：2022-11-16

申请人： EDWARDS LIFESCIENCES CORPORATION

发明人： DVORSKY, Anatoly ,  WITZMAN, Ofir ,  MAIMON, David

IPC分类号： A61F2/24

摘要： Method and devices for displacing leaflets of an existing valvular structure at an aortic valve position away from coronary ostia of an aorta are disclosed. An example method can include implanting a prosthetic heart valve within a native valve or previously implanted heart valve such that a commissure of the prosthetic heart valve is circumferentially aligned with a mid-portion of a leaflet of the native or previously implanted heart valve. The method further includes, during radially expanding the prosthetic heart valve into the native or previously implanted heart valve, applying pressure to the mid-portion of the leaflet with the commissure such that the leaflet is displaced away from the commissure and toward an inflow end of the prosthetic heart valve.

公开(公告)号：WO2023091419A1

公开(公告)日：2023-05-25

申请号：PCT/US2022/049975

申请日：2022-11-15

申请人： EDWARDS LIFESCIENCES CORPORATION

发明人： LEVI, Tamir, S. ,  YOHANAN, Ziv ,  BASH, Assaf

IPC分类号： A61B17/04 ,  A61B17/06 ,  A61B17/00 ,  A61B17/068 ,  A61B17/064 ,  A61F2/06 ,  A61F2/24

摘要： A method of valve implantation includes installing a leaflet lasso on a host leaflet assembly at an implantation site within a patient's body. The method includes positioning an expandable prosthetic heart valve in a crimped state within a central region of the host leaflet assembly. The method includes radially expanding the prosthetic heart valve to a working diameter. During at least a portion of radially expanding the prosthetic heart valve, the prosthetic heart valve contacts a central lasso portion of the leaflet lasso and applies a radial force to the central lasso portion that results in folding of at least one leaflet of the leaflet assembly.

公开(公告)号：WO2023088392A1

公开(公告)日：2023-05-25

申请号：PCT/CN2022/132662

申请日：2022-11-17

申请人： 北京佰仁医疗科技股份有限公司

发明人： 金磊 ,  魏来 ,  吴康健 ,  吴嘉 ,  范志豪 ,  李丽艳

IPC分类号： A61F2/24

摘要： 一种分体式可精准锚定的介入环中瓣系统，包括分体的介入环中瓣锚定支架（10）和介入人工生物环中瓣（20），介入环中瓣锚定支架（10）的形态和结构与此前植入过瓣膜成形环（30）发生术后瓣膜失功的患者影像数据经三维重建后的瓣环及瓣上和瓣下的真实结构相匹配，介入环中瓣锚定支架（10）首先被输送至患者失功瓣环内释放、形变、与失功瓣环的瓣上和瓣下组织对位接合；介入人工生物环中瓣（20）被输送至介入环中瓣锚定支架（10）内释放，介入人工生物环中瓣（20）的瓣膜支架形变扩启至介入环中瓣的功能状态，使介入环中瓣锚定支架（10）再次形变与扩启的介入环中瓣结合，同时介入环中瓣锚定支架（10）的再次形变致介入环中瓣锚定支架（10）与瓣下结构再次结合而锚定。

公开(公告)号：WO2023088369A1

公开(公告)日：2023-05-25

申请号：PCT/CN2022/132578

申请日：2022-11-17

申请人： 北京佰仁医疗科技股份有限公司

发明人： 金磊 ,  郭应强 ,  吴嘉 ,  李丽艳 ,  慕宏 ,  吴康健 ,  范志豪

IPC分类号： A61F2/24

摘要： 一种分体式可精准锚定的介入二尖瓣系统，包括分体的介入二尖瓣锚定支架（10）和介入人工生物二尖瓣（20），介入二尖瓣锚定支架（10）的形态和结构与患者影像数据经三维重建后的二尖瓣真实结构相匹配，介入二尖瓣锚定支架（10）先被输送至患者二尖瓣位释放、形变、与患者二尖瓣位瓣上和瓣下的组织个性化精准对位接合；介入人工生物二尖瓣（20）被输送至介入二尖瓣锚定支架（10）内释放，介入人工生物二尖瓣（20）被释放形变扩启至功能状态，使介入二尖瓣锚定支架（10）再次形变与扩启的介入人工生物二尖瓣（20）结合，同时介入二尖瓣锚定支架（10）的再次形变致介入二尖瓣锚定支架（10）与瓣下组织完成事先预设的结合而锚定。该分体式可精准锚定的介入二尖瓣系统基于三维重建而设计的系统，可以实现介入二尖瓣个性化的精准锚定。

公开(公告)号：WO2023086548A1

公开(公告)日：2023-05-19

申请号：PCT/US2022/049666

申请日：2022-11-11

申请人： EDWARDS LIFESCIENCES CORPORATION

发明人： LEVI, Tamir, S. ,  SHERMAN, Elena ,  LAZOVSKI, Shir ,  YOHANAN, Ziv ,  GUROVICH, Nikolai ,  PHAM, Bich, Hoang

IPC分类号： A61F2/24

摘要： A prosthetic heart valve including a plurality of leaflets attached to the frame is disclosed. The plurality of leaflets is disposed within the frame and configured to regulate the flow of blood through the frame in one direction, each leaflet comprising a cusp edge portion. The prosthetic heart valve can further include at least one suture extending along a cusp edge portion of at least a first leaflet of the plurality of leaflets, a plurality of in-and-out stitches extending through the suture and the cusp edge portion of the first leaflet, and a plurality of whip stitches that extend around selected struts of the frame and the suture to couple the cusp edge portion of the first leaflet to the frame.

公开(公告)号：WO2023086147A1

公开(公告)日：2023-05-19

申请号：PCT/US2022/042079

申请日：2022-08-30

申请人： BOSTON SCIENTIFIC SCIMED, INC.

发明人： GIESE, Troy Anthony ,  EGGERT, Joel T. ,  BARRON, Nicholas ,  JONES, Matthew P. ,  OTT, Kristen Elizabeth

IPC分类号： A61B17/128 ,  A61F2/24 ,  A61B17/122 ,  A61B17/00

摘要： Implantable devices formed of materials which are not readily imageable are delivered and deployed with a deployment/delivery device having one or more sensors generating a signal indicating a condition of the implantable device relative to the deployment site. For instance, the signal indicates at least one or more of the following: purchase of the implantable device with tissue, level of purchase of the implantable device with tissue, the position of the implantable device relative to the deployment site, seating of tissue with respect to the implantable device, extent of contact of the implantable device with tissue, or further information about the implantable device and/or the delivery/deployment device. As such, the implantable device need not be imaged to determine the relationship of the implantable device relative to the deployment site.

公开(公告)号：WO2023082579A1

公开(公告)日：2023-05-19

申请号：PCT/CN2022/092937

申请日：2022-05-16

申请人： 上海臻亿医疗科技有限公司 ,  江苏臻亿医疗科技有限公司

发明人： 张海军 ,  赵婧 ,  刘祥

IPC分类号： A61F2/24

摘要： 一种人工心脏瓣膜，用以设置在右心房(1)和右心室(2)之间，包括外层支架(100)、裙边(200)和人工瓣叶(300)。外层支架(100)包括沿轴向依次连接的法兰段(110)、主体段(120)和抓耳段(130)。法兰段(110)的直径沿轴向朝向远离主体段(120)侧逐渐增大，并用于压设在三尖瓣瓣环(3)上。主体段(120)用以设置在三尖瓣瓣叶(4)的内侧。抓耳段(130)包括隔瓣抓耳(131)和前后瓣抓耳(132)。隔瓣抓耳(131)用以锚固在三尖瓣瓣叶(4)的隔瓣上，前后瓣抓耳(132)用以锚固在三尖瓣瓣叶(4)的前瓣和/或后瓣上，使得三尖瓣瓣叶(4)夹持在法兰段(110)和抓耳段(130)之间，且前后瓣抓耳(132)的长度大于隔瓣抓耳(131)的长度。

公开(公告)号：WO2023081236A1

公开(公告)日：2023-05-11

申请号：PCT/US2022/048744

申请日：2022-11-02

申请人： EDWARDS LIFESCIENCES CORPORATION

发明人： BECERRA, Matthew, Michael ,  LANDON, David, Robert ,  SAFFARI, Payam ,  KAUFMAN, Yevgeniy, Davidovich ,  EDWARDS, Jesse, Robert ,  TAYLOR, David, M. ,  SHARY, Scott, Louis ,  WHITE, Richard, D.

IPC分类号： A61F2/24

摘要： A prosthetic heart valve delivery system having one or more features which facilitate access to a target annulus and improve maneuverability. The system may have a flexible access sheath having an inner lumen and a proximal handle attached to an elongated flexible catheter extending distally therefrom and having an outer diameter sized to fit through the access sheath. An expandable prosthetic heart valve is crimped and positioned in an inner lumen and near the distal end of the delivery catheter. A distal tapered nose cone attaches to the delivery catheter and facilitates passage through the patient's vasculature. An inner tube extends from the proximal handle through the delivery catheter inner lumen, through the prosthetic heart valve, and attaches to the nose cone. Finally, the system has a guidewire that extends through the proximal handle along the delivery catheter and projects distally from the nose cone. The system is especially useful for transfemoral atrioventricular valve replacements.

公开(公告)号：WO2023076516A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/048089

申请日：2022-10-27

申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY ,  MARSDEN, Alison ,  MA, Michael

发明人： HAN, Kyung Won ,  CUTKOSKY, Mark R.

IPC分类号： A61F2/24

摘要： Devices and methods are provided for inducing ventricular growth in a single ventricle patient that include a plurality of anchors spaced apart from one another in an annular configuration; a plurality of springs with respective springs coupled to adjacent anchors around a perimeter of the annular configuration to bias the anchors to expand radially outwardly; and one or more elongate elements extending around the perimeter between the anchors to limit radial expansion of the anchors.

公开(公告)号：WO2023069518A1

公开(公告)日：2023-04-27

申请号：PCT/US2022/047134

申请日：2022-10-19

申请人： RAJAGOPAL, Keshava

发明人： RAJAGOPAL, Keshava

IPC分类号： A61F2/24

摘要： A transcatheter valve implant assembly has a ventricular assist device, a prosthetic valve, a stent frame structure, and a docking station, and is implanted at an aortic or a pulmonary valve. During implantation, the native valve leaflets of the respective valve at the implantation site are engaged with the prosthetic valve and/or the stent frame structure while the stent frame structure is connected to the docking station with the prosthetic valve adjacent to the proximal end of the stent frame structure. The ventricular assist device is inserted into the interior the stent frame structure with an inlet of ventricular assist device positioned in the respective ventricle associated with the implantation site and the outlet of the ventricular assist device positioned to discharge into the respective blood vessel associated with the implantation site. The ventricular assist device is releasably connected with the stent frame structure and the docking station.