公开(公告)号：WO2020014301A1

公开(公告)日：2020-01-16

申请号：PCT/US2019/041119

申请日：2019-07-10

Applicant: CTEC LLC

Inventor： LUCKE-WOLD, Brandon ,  TURNER, Ryan ,  LOGSDON, Aric

IPC: A61K31/47 ,  C07D215/40

Abstract: The invention relates to compounds, compositions and methods to effectively treat traumatic brain injury (TBI) and chronic traumatic encephalopathy (CTE). As a result of administering a therapeutically effective amount of 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino) thioxomethyl] amino] ethyl]-2-propenamide and/or guanabenz, the effects of traumatic brain injury are mitigated and/or the development of chronic traumatic encephalopathy is reduced or precluded.