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公开(公告)号：WO2023049177A1
公开(公告)日：2023-03-30
申请号：PCT/US2022/044245
申请日：2022-09-21
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Abstract: The present description provides methods, assays and reagents for linearly expanding a peptide. The methods and/or linear expanded peptide described herein have several uses such as, but not limited to, peptide (protein) sequencing, high-resolution interrogation of the proteome and enabling ultrasensitive diagnostics critical for early detection of diseases.
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公开(公告)号：WO2020146325A1
公开(公告)日：2020-07-16
申请号：PCT/US2020/012502
申请日：2020-01-07
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： ESTANDIAN, Daniel, Masao , CHOUEIRI, Alexi, Georges , BOYDEN, Edward, Stuart , WASSIE, Asmamaw
Abstract: The present description provides methods, assays and reagents useful for sequencing proteins. Sequencing proteins in a broad sense involves observing the plausible identity and order of amino acids, which is useful for sequencing single polypeptide molecules or multiple molecules of a single polypeptide. In one aspect, the methods are useful for sequencing multiple polypeptides. The methods and reagents described herein can be useful for high resolution interrogation of the proteome and enabling ultrasensitive diagnostics critical for early detection of diseases.
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