公开(公告)号：WO2017004274A3

公开(公告)日：2017-01-05

申请号：PCT/US2016/040212

申请日：2016-06-29

Applicant: NANTBIOSCIENCE, INC.

Inventor： RABIZADEH, Shahrooz ,  BUZKO, Oleksandr ,  WEINGARTEN, Paul ,  MCFARLANE, Heather ,  TSAI, Connie ,  BENZ, Stephen Charles ,  NIAZI, Kayvan ,  SOON-SHIONG, Patrick

IPC: A61K31/415 ,  A61K31/4453 ,  A61K31/4465 ,  A61K31/538 ,  A61K45/06

Abstract: Various compounds, compositions, and methods for inhibition of Rit1 are presented. In especially preferred aspects, contemplated compounds and compositions are suitable for treatment of cancers and other diseases associated with Rit1 signaling.

公开(公告)号：WO2017004274A2

公开(公告)日：2017-01-05

申请号：PCT/US2016/040212

申请日：2016-06-29

Applicant: NANTBIOSCIENCE, INC.

Inventor： RABIZADEH, Shahrooz ,  BUZKO, Oleksandr ,  WEINGARTEN, Paul ,  MCFARLANE, Heather ,  TSAI, Connie ,  BENZ, Stephen Charles ,  NIAZI, Kayvan ,  SOON-SHIONG, Patrick

IPC: A61K31/415 ,  A61K31/4453 ,  A61K31/4465 ,  A61K31/538 ,  A61K45/06

CPC classification number: A61K31/4196 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/538 ,  A61K45/06 ,  A61P35/00 ,  A61K2300/00

Abstract: Various compounds, compositions, and methods for inhibition of Rit1 are presented. In especially preferred aspects, contemplated compounds and compositions are suitable for treatment of cancers and other diseases associated with Rit1 signaling.

Abstract translation: 介绍了用于抑制Rit1的各种化合物，组合物和方法。 在特别优选的方面，所考虑的化合物和组合物适用于治疗与Rit1信号传导相关的癌症和其他疾病。

公开(公告)号：WO2016161361A1

公开(公告)日：2016-10-06

申请号：PCT/US2016/025697

申请日：2016-04-01

Applicant: NANTBIOSCIENCE, INC. ,  NANTOMICS, LLC ,  NANT HOLDINGS IP, LLC

Inventor： RABIZADEH, Shahrooz ,  KAYVAN, Niazi ,  BUZKO, Sasha ,  WEINGARTEN, Paul ,  MCFARLANE, Heather ,  JUNCKER-JENSEN, Anna ,  GOLOVATO, Justin ,  SOON-SHIONG, Patrick ,  TAO, Chunlin ,  HO, David

IPC: C07D417/12 ,  C07D417/14 ,  A61K31/427 ,  A61K31/4725 ,  A61P35/00

CPC classification number: C07D417/14 ,  A61P35/00 ,  C07D277/46 ,  C07D417/04 ,  C07D417/12 ,  C07D471/06 ,  C07F9/65583

Abstract: Compounds and compositions are presented that inhibit K-ras, and especially mutant K-ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.

Abstract translation: 提供了抑制K-ras，尤其是突变型K-ras的化合物和组合物。 某些化合物优先或甚至选择性抑制特定形式的突变型K-Ras，特别是G12D突变体形式。