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1.发明申请
公开(公告)号：WO2019125512A1
公开(公告)日：2019-06-27
申请号：PCT/US2018/035259
申请日：2018-05-31
Applicant: ORIG3N, INC.
Inventor： SMITH, Robin Y. , GLICKSMAN, Marcie A. , FRAZIER, Shadrack Cgar
Abstract: Presented herein are systems and methods for automatically managing and filtering social media interactions and/or online content based on genetic profiles of users. These genetic profiles include identifications of genetic interests of the users and/or genetic information to which they have permitted access. Such permissioned personal genetic profiles may be used to facilitate, manage, and filter a variety of online interactions between the user and other members of various services and/or online content in order to lead to meaningful and successful real world interactions and/or to improve the relevance of online content delivered to a user.
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2.发明申请
公开(公告)号：WO2018140156A1
公开(公告)日：2018-08-02
申请号：PCT/US2017/067277
申请日：2017-12-19
Applicant: ORIG3N, INC.
Inventor： SMITH, Robin Y. , GLICKSMAN, Marcie A. , GUPTA, Sunil Anant , COFFEY, Edward Joseph , BLANCHARD, Kate , LENTO, Stephanie , FRAZIER, Shadrack Cgar
Abstract: Presented herein are systems and methods for automatically identifying and recommending purchases (e.g., in-app purchases) to a user based on the user's personal genetic profile. In certain embodiments, offers for such purchases are conveniently presented in the same software application (e.g., smartphone app or other computing device application) in which a user securely accesses his or her personalized genetic profile test results. Also presented herein are systems and methods for computer application developers to customize apps for presentation of recommended purchases based on a user's personal genetic profile. In certain embodiments, the systems and methods described herein provide for issuing of genetically tailored notifications to one or more mobile health devices of an individual based on an assessment of the individual's genetic profile. Such notifications, for example, can assist an individual in their adherence to particular recommended regiments, such as workout regimens.
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3.发明申请
公开(公告)号：WO2019045774A1
公开(公告)日：2019-03-07
申请号：PCT/US2018/022319
申请日：2018-03-14
Applicant: ORIG3N, INC.
Inventor： SMITH, Robin Y. , GLICKSMAN, Marcie A.
IPC: A61K35/17 , C07K14/705 , C07K16/30 , C07K14/725 , C12N5/0783
Abstract: Presented herein are systems and methods of producing "universal" and/or "off-the-shelf" CAR-T compositions suitable for cancer therapy to be administered to one or more individuals. A CAR-T composition is a composition comprising one or more types of chimeric antigen receptor T cells (CAR-T). The iPSCs and/or cell lines, and any iPSC-derived CAR-T compositions derived therefrom, are identified as compatible with one or more individuals using an identification of a cell type indicative of compatibility (e.g., HLA match and/or ABO blood match and/or RHD blood match). The compatible cells are then retrieved from a managed HLA-indexed (and/or otherwise indexed) repository or are derived from a biological sample of a donor. The retrieved compatible cells are then used to derive iPSC-derived CAR-T compositions, wherein the derived compositions are suitable for therapy of one or more individuals.
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4.发明申请
公开(公告)号：WO2018170046A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/022317
申请日：2018-03-14
Applicant: ORIG3N, INC.
Inventor： SMITH, Robin Y. , GLICKSMAN, Marcie A.
IPC: C12N5/0797 , C12N5/0789 , C12N5/095 , G06F17/30 , A61K35/28 , A61K35/545
Abstract: Described herein is a managed, indexed repository of hematopoietic stem cell (HSC) lines and/or blood progenitor cell lines derived from induced pluripotent stem cells (iPSCs) (or embryoid bodies formed from iPSCs), wherein each of the HSC lines, blood progenitor cell lines, embryoid bodies, and/or iPSC lines has corresponding data comprising a set of characterized HLA loci, said corresponding data being stored in a searchable database for retrieval of one or more matching physical cell lines upon query. The repository comprises an HLA-indexed bank of iPSCs, embryoid bodies, HSCs, and/or blood progenitor cells for each of a set of HLA types, for identification and provision of allogeneic cell lines suitable for transplantation to reestablish hematopoietic function in patients with damaged, diseased, or otherwise abnormal bone marrow and/or immune system.
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公开(公告)号：WO2018089630A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/060856
申请日：2017-11-09
Applicant: ORIG3N, INC.
Inventor： SMITH, Robin Y. , BLANCHARD, Kate
Abstract: Described herein are various systems, methods, apparatuses, and kits for phlebotomy. In certain embodiments, the phlebotomy kit or system includes a blood collection tube, a needle assembly, a holder for the blood collection tube, a bandage, a tourniquet, a wipe, and an absorbent pad. The disclosed systems, methods, apparatuses, and kits are useful for collecting a single small volume of blood, and collecting of a small volume of blood at remote non-hospital environments.
Abstract translation: 这里描述的是用于静脉切开术的各种系统，方法，装置和试剂盒。 在某些实施方案中，静脉切开术套件或系统包括采血管，针组件，用于血液采集管的支架，绷带，止血带，擦拭物和吸收垫。 所公开的系统，方法，装置和试剂盒可用于收集单个小体积的血液以及在偏远的非医院环境下收集少量血液。
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Patent Agency Ranking
公开(公告)号：WO2019173376A1
公开(公告)日：2019-09-12
申请号：PCT/US2019/020804
申请日：2019-03-05
Applicant: ORIG3N, INC.
Inventor： SMITH, Robin Y. , GLICKSMAN, Marcie A. , CORNIVELLI, Lizbeth
Abstract: Presented herein are personalized compositions comprising iPSCs and/or iPSC-derived cells (cells) and methods of producing personalized compositions suitable for various therapies, including chondrogenesis therapies, to be administered to an individual or a group of individuals. The cells and/or cell lines, and any compositions derived therefrom, are identified as compatible with a specific individual or specific group of individuals using an identification of a cell type indicative of compatibility such as an HLA match. The compatible cells are then used to derive "personalized" compositions, wherein the "personalized" compositions comprise one or more cell-secreted molecules suitable for therapy. It is found herein that a composition comprising one or more iPSC-derived MSCs, iPSC-derived chondrocytes, and iPSC-derived chondrons may provide improved treatment efficacy than would be offered by bone marrow-MSCs (BM-MSCs) or compositions comprising BM-MSCs.
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公开(公告)号：WO2019045775A1
公开(公告)日：2019-03-07
申请号：PCT/US2018/022325
申请日：2018-03-14
Applicant: ORIG3N, INC.
Inventor： SMITH, Robin Y. , GLICKSMAN, Marcie A.
Abstract: Presented herein are methods of producing "personalized" secretome compositions suitable for secretome based therapy to be administered to a specific individual and/or specific group of individuals. The iPSCs and/or iPSC-derived cells, and any iPSC-derived compositions derived therefrom, are identified as compatible with a specific individual or specific group of individuals using an identification of a cell type indicative of compatibility such as an HLA match and/or ABO blood match and/or RHD blood group match. The identified compatible cells are then retrieved from a managed HLA-indexed (and/or otherwise indexed) repository or are derived from a biological sample of a suitable donor. The retrieved compatible cells are then used to derive the "personalized" iPSC-derived secretome compositions, that comprise the complete secretome or a subset of the secretome suitable for treatment of a specific individual and/or specific group of individuals.
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8.发明申请
公开(公告)号：WO2018144693A1
公开(公告)日：2018-08-09
申请号：PCT/US2018/016382
申请日：2018-02-01
Applicant: ORIG3N, INC.
Inventor： SMITH, Robin Y. , GLICKSMAN, Marcie A.
IPC: A61K35/407 , A61K35/545 , C12N5/071 , C12N5/074
CPC classification number: A61K35/12 , A61K35/545
Abstract: Described herein are various systems and methods for customizing cell culture media for optimized cell proliferation based on genetic traits of the cells. Factors of the cells, such as genetics, can determine the optimum cell culture conditions for growth and use of individual cells in vitro. In certain embodiments, genetics can determine sensitivity from a toxic perspective. In certain embodiments, genetics can determine what concentration(s) of growth factor(s) and nutrient(s) are required for optimum growth.
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公开(公告)号：WO2020009920A1
公开(公告)日：2020-01-09
申请号：PCT/US2019/039735
申请日：2019-06-28
Applicant: ORIG3N, INC.
Inventor： SMITH, Robin Y.
Abstract: Embodiments of the present invention provide convenient foldable boxes for transporting materials related to genetic assessments (e.g., DNA tests). The foldable boxes are lightweight, compact, easily manufactured, and inexpensive. In certain embodiments, the present disclosure is directed to a genetic assessment kit which includes a foldable box, as described herein, a buccal swab, and other materials which support the efficient and collection and transport of a biological sample. For example, the genetic assessment kit may include a plastic bag or other appropriate vessel for storing a buccal swab after it is used to collect a biological sample (e.g., a DNA sample). The genetic assessment kit may also include a pre-addressed envelope so an individual may easily mail his/her biological sample to an appropriate test location.
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10.发明申请
公开(公告)号：WO2018190914A1
公开(公告)日：2018-10-18
申请号：PCT/US2017/067272
申请日：2017-12-19
Applicant: ORIG3N, INC.
Inventor： SMITH, Robin Y. , GUPTA, Sunil Anant , BLANCHARD, Kate , COFFEY, Edward Joseph , GLICKSMAN, Marcie A.
IPC: G16H10/40
Abstract: Described herein are systems and methods to record and track, via a graphical user interface, biological samples, and biological material extracted therefrom, used to generate genotyping data. As biological samples are processed in several stages to extract biological material and perform genotyping tests, IDs are assigned to biological samples and biological material for individuals as well as well plates used during processing of the biological samples and the biological material in order to organize the samples and the tests. Biological samples are assigned to well plates for use in extracting biological material. Biological material is assigned to genotyping plates for use in performing genotyping tests. By associating IDs corresponding to biological samples or biological material with IDs for well plates or genotyping plates, respectively, a user can track which extractions and/or tests need to be performed and record which biological samples have been received or genotyping plates analyzed.
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