公开(公告)号：WO2019140315A2

公开(公告)日：2019-07-18

申请号：PCT/US2019/013367

申请日：2019-01-11

Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  THE GENERAL HOSPITAL CORPORATION

Inventor： PAREKKADAN, Biju ,  LI, Matthew

IPC: C12N5/07

Abstract: Systems and methods for the dynamic co-culturing of two cell populations are provided. The system includes a barrier configured to physically separate a stimulator cell population from a responder cell population disposed within a container. The barrier is permeable to the secreted factors of at least one of the cell populations. The responder cell population can thereby be altered by exposure to the secreted factors to produce a population of reprogrammed cells that includes biomolecules (e.g., nucleic acids) originating from the stimulator cell population and/or that exhibits one or more additional or modified functional activities than a parental population of the reprogrammed cells.

公开(公告)号：WO2019140315A3

公开(公告)日：2019-07-18

申请号：PCT/US2019/013367

申请日：2019-01-11

Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  THE GENERAL HOSPITAL CORPORATION

Inventor： PAREKKADAN, Biju ,  LI, Matthew

IPC: A61K35/15

Abstract: Systems and methods for the dynamic co-culturing of two cell populations are provided. The system includes a barrier configured to physically separate a stimulator cell population from a responder cell population disposed within a container. The barrier is permeable to the secreted factors of at least one of the cell populations. The responder cell population can thereby be altered by exposure to the secreted factors to produce a population of reprogrammed cells that includes biomolecules (e.g., nucleic acids) originating from the stimulator cell population and/or that exhibits one or more additional or modified functional activities than a parental population of the reprogrammed cells.

公开(公告)号：WO2019104154A1

公开(公告)日：2019-05-31

申请号：PCT/US2018/062229

申请日：2018-11-21

Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

Inventor： PAREKKADAN, Biju ,  AIJAZ, Ayesha

IPC: C12M1/12 ,  C12N5/00

CPC classification number: C12M25/16 ,  C12N5/0012 ,  C12N5/0663 ,  C12N2533/30

Abstract: Systems and methods for growing cells are provided. A capsule for growing or storing cells includes a shell defining an interior compartment and a substrate for cell attachment located within the compartment. The substrate comprises a polymer and one or more adhesion molecules. The substrate for cell attachment can be an inner surface of the shell and/or a hydrogel disposed within the interior compartment. The capsule can further include a cell, such as a stem cell, adhered to the substrate

公开(公告)号：WO2020176744A1

公开(公告)日：2020-09-03

申请号：PCT/US2020/020125

申请日：2020-02-27

Applicant: THE GENERAL HOSPITAL CORPORATION ,  RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

Inventor： PAREKKADAN, Biju ,  BURR, Alexandra ,  TAMAYO, Alfred

IPC: C07K14/575 ,  C07K14/605 ,  A61K38/00 ,  A61K38/17

Abstract: Methods and compositions for use in engineering cells to secrete therapeutic biomolecules into the blood stream in vivo in response to an individual's personal biological needs.