公开(公告)号：WO2021141507A1

公开(公告)日：2021-07-15

申请号：PCT/PL2020/050005

申请日：2020-01-10

Applicant: UNIWERSYTET JAGIELLOŃSKI

Inventor： CHŁOPICKI, Stefan ,  KALVINS, Ivars ,  PRZYBOROWSKI, Kamil ,  STOJAK, Marta ,  ANDRIANOV, Victor ,  DOMRACEVA, Ilona ,  KANEPE-LAPSA, Iveta ,  ZELENCOVA, Diana ,  WIETRZYK, Joanna ,  TURLEJ, Eliza ,  STACHOWICZ, Martyna ,  JAROSZ, Joanna ,  MILCZAREK, Magdalena ,  KRAMKOWSKI, Karol

IPC: A61P7/00 ,  A61P9/00 ,  A61P35/00 ,  C07D203/24 ,  C07D401/12 ,  C07D405/12 ,  A61K31/396

Abstract: The invention relates to a new group of aromatic sulphonamides derivatives of formula (I) and their synthesis and use for modulation of the activity of protein disulfide isomerase (PDI). More particularly, the invention provides small molecule inhibitors of PDI A3 that display antiplatelet, antithrombotic and anticancer activities.

公开(公告)号：WO2021141506A1

公开(公告)日：2021-07-15

申请号：PCT/PL2020/050004

申请日：2020-01-10

Applicant: UNIWERSYTET JAGIELLOŃSKI

Inventor： KALVINS, Ivars ,  CHŁOPICKI, Stefan ,  ANDRIANOV, Victor ,  STOJAK, Marta ,  DOMRACEVA, Ilona ,  KANEPE-LAPSA, Iveta ,  ZELENCOVA, Diana ,  WIETRZYK, Joanna ,  TURLEJ, Eliza ,  STACHOWICZ, Martyna ,  JAROSZ, Joanna ,  MILCZAREK, Magdalena ,  KRAMKOWSKI, Karol

IPC: A61P7/00 ,  A61P9/00 ,  A61P35/00 ,  C07D203/24 ,  C07D401/12 ,  C07D405/12 ,  A61K31/396

Abstract: The invention relates to a new group of aromatic sulphonamides derivatives of formula (I) and their synthesis and use for modulation of the activity of protein disulfide isomerase (PDI). More particularly, the invention provides small molecule inhibitors of PDI A1 that display antiplatelet, antithrombotic and anticancer activities.