公开(公告)号：WO2022250553A1

公开(公告)日：2022-12-01

申请号：PCT/PL2022/050030

申请日：2022-05-23

Applicant: UNIWERSYTET JAGIELLOŃSKI

Inventor： MALEC, Przemysław ,  ŻBIK, Paweł

IPC: B01D15/32 ,  B01D11/02 ,  C07C403/24 ,  A61K31/047

Abstract: The subject of the invention is a method of obtaining high-purity myxoxanthophylls, consisting of solvent extraction using sonication, centrifugation, decantation of the supernatant, obtaining the extract by evaporating the solvent or solvent mixture, purifying the dissolved extract on a chromatographic column, all steps being carried out in the absence of light.

公开(公告)号：WO2021235956A2

公开(公告)日：2021-11-25

申请号：PCT/PL2021/050033

申请日：2021-05-20

Applicant: UNIWERSYTET JAGIELLOŃSKI

Inventor： PANEK, Dawid ,  MALAWSKA, Barbara ,  PASIEKA, Anna ,  JOŃCZYK, Jakub ,  WIĘCKOWSKA, Anna ,  GODYŃ, Justyna ,  SZAŁAJ, Natalia ,  BAJDA, Marek ,  SAŁAT, Kinga

IPC: C07C215/28 ,  C07C217/58 ,  C07C233/11 ,  C07C233/62 ,  A61K31/137 ,  A61K31/165 ,  A61P25/28 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2603/18

Abstract: A group of novel 9H-fluorcnc derivatives suitable for the preparation of active substances for the treatment of Alzheimer's disease, in particular as multifunctional inhibitors of the BuChE and BACE1 enzymes and beta-amyloid aggregation.

公开(公告)号：WO2021141507A1

公开(公告)日：2021-07-15

申请号：PCT/PL2020/050005

申请日：2020-01-10

Applicant: UNIWERSYTET JAGIELLOŃSKI

Inventor： CHŁOPICKI, Stefan ,  KALVINS, Ivars ,  PRZYBOROWSKI, Kamil ,  STOJAK, Marta ,  ANDRIANOV, Victor ,  DOMRACEVA, Ilona ,  KANEPE-LAPSA, Iveta ,  ZELENCOVA, Diana ,  WIETRZYK, Joanna ,  TURLEJ, Eliza ,  STACHOWICZ, Martyna ,  JAROSZ, Joanna ,  MILCZAREK, Magdalena ,  KRAMKOWSKI, Karol

IPC: A61P7/00 ,  A61P9/00 ,  A61P35/00 ,  C07D203/24 ,  C07D401/12 ,  C07D405/12 ,  A61K31/396

Abstract: The invention relates to a new group of aromatic sulphonamides derivatives of formula (I) and their synthesis and use for modulation of the activity of protein disulfide isomerase (PDI). More particularly, the invention provides small molecule inhibitors of PDI A3 that display antiplatelet, antithrombotic and anticancer activities.

公开(公告)号：WO2020251379A1

公开(公告)日：2020-12-17

申请号：PCT/PL2020/050048

申请日：2020-06-12

Applicant: UNIWERSYTET JAGIELLOŃSKI

Inventor： TURNAU, Katarzyna ,  WAŻNY, Rafał ,  ROZPĄDEK, Piotr

IPC: A01N63/30 ,  C12N1/14 ,  A01N25/08 ,  A01N25/04

Abstract: The invention relates to inoculum for biotization of American blueberry, comprising Xylaria sp. strain No. KKP 2073p, deposited in the International Collection of Industrial Microorganisms of the Institute of Agricultural and Food Biotechnology in Warsaw under the number KKP 2073p., a method of preparing the inoculum for biotization of American blueberry and a method of biotization of American blueberry.

公开(公告)号：WO2020185104A1

公开(公告)日：2020-09-17

申请号：PCT/PL2020/050021

申请日：2020-03-11

Applicant: UNIWERSYTET JAGIELLOŃSKI ,  LIPID SYSTEMS SP. Z O.O.

Inventor： BAR, Anna ,  BOROWIK, Tomasz ,  CHŁOPICKI, Stefan ,  LANGNER, Marek ,  PRZYBYŁO, Magdalena

IPC: A61K49/18

Abstract: MRI contrast agent for use in the diagnosis of early changes in the endothelium of blood vessels

公开(公告)号：WO2020171724A1

公开(公告)日：2020-08-27

申请号：PCT/PL2020/050020

申请日：2020-02-21

Applicant: UNIWERSYTET JAGIELLOŃSKI

Inventor： STĘPIEŃ, Ewa Łucja ,  KAMIŃSKA, Agnieszka ,  PIEKOSZEWSKI, Wojciech ,  KASPRZYK, Joanna

IPC: G01N33/68 ,  G01N33/543

Abstract: A method is disclosed of determination of the degree of renal damage occurring in subjects with diabetes, wherein gal-3 protein concentration is determined in a urine sample from a subject suffering from diabetes.

公开(公告)号：WO2020145831A1

公开(公告)日：2020-07-16

申请号：PCT/PL2020/050001

申请日：2020-01-07

Applicant: UNIWERSYTET JAGIELLOŃSKI ,  WARSZAWSKI UNIWERSYTET MEDYCZNY

Inventor： KAMIŃSKI, Krzysztof ,  ABRAM, Michał ,  RAPACZ, Anna ,  MOGILSKI, Szczepan ,  LATACZ, Gniewomir ,  SZULCZYK, Bartłomiej

IPC: C07D401/06 ,  C07D207/40 ,  C07D207/416 ,  A61P25/06 ,  A61P25/08 ,  A61K31/4465 ,  A61K31/4015

Abstract: The first object of the invention is the compound of general formula (I) or pharmaceutically acceptable salts thereof. A second object of the invention is the use of compounds described by general formula (I) as active ingredient in pharmaceutical compositions for the treatment of epileptic seizures or neuropathic pain or migraine.

公开(公告)号：WO2019177475A1

公开(公告)日：2019-09-19

申请号：PCT/PL2019/050015

申请日：2019-03-13

Applicant: UNIWERSYTET JAGIELLOŃSKI

Inventor： NOWAKOWSKA, Maria ,  PYRĆ, Krzysztof ,  SZCZUBIAŁKA, Krzysztof ,  PACHOTA, Magdalena

IPC: A61K31/785 ,  A61P31/22

Abstract: The invention relates to the use of block copolymers with chains composed of a polyethylene glycol) (PEG) block and poly(3-(methacryloylamino)propyl)trimethylammonium chloride) (PMAPTAC) block for the preparation of a formulation for the treatment and prophylaxis of diseases caused by the HSV-1 virus.

公开(公告)号：WO2018199785A1

公开(公告)日：2018-11-01

申请号：PCT/PL2018/050016

申请日：2018-04-26

Applicant: UNIWERSYTET JAGIELLOŃSKI

Inventor： KAMIŃSKI, Kamil ,  JAROSZ, Magdalena ,  GAWLAK, Karolina ,  GRUDZIEŃ, Joanna ,  SULKA, Grzegorz D. ,  NOWAKOWSKA, Maria

IPC: H01M8/16 ,  H01M4/88 ,  H01M4/90 ,  C12R1/225

CPC classification number: C12N1/20 ,  H01M4/8825 ,  H01M4/8842 ,  H01M4/90 ,  H01M8/16 ,  Y02E60/527

Abstract: A method for preparation of a layer of a bacterial biofilm of Lactobacillus rhamnosus GG on a surface of gold, by covering the metal with a polycation using the LbL method, and a bioelectrode obtained by this method and the electrode's application, are disclosed.

公开(公告)号：WO2016083911A1

公开(公告)日：2016-06-02

申请号：PCT/IB2015/056710

申请日：2015-09-03

Applicant: UNIWERSYTET JAGIELLOŃSKI

Inventor： BERETA, Joanna ,  JUCHA, Jarosław

IPC: C12N9/42 ,  C07K1/22 ,  C07K14/315

CPC classification number: C12N9/2442 ,  C07K1/22 ,  C07K14/315 ,  C12Y302/01014

Abstract: A protein complex containing protein G and non-covalently bound chitinase A or a protein containing a chitinase fragment with affinity to protein G and the method of separation of chitinase A or or a protein containing a chitinase fragment with affinity to protein G from a water solution were disclosed.

Abstract translation: 含有蛋白G和非共价结合的几丁质酶A或含有对蛋白G具有亲和性的几丁质酶片段的蛋白质的蛋白质复合物和从水溶液中与蛋白G具有亲和力的几丁质酶A或含有几丁质酶片段的蛋白质的分离方法 被披露。