公开(公告)号：WO2022104011A1

公开(公告)日：2022-05-19

申请号：PCT/US2021/059073

申请日：2021-11-12

申请人： YUMANITY THERAPEUTICS, INC.

发明人： VINCENT, Benjamin ,  TARDIFF, Daniel ,  PIOTROWSKI, Jeffrey ,  CHANG, Belle ,  CHOI, Jeonghoon ,  CHUNG, Chee-Yeun ,  SCANNEVIN, Robert

IPC分类号： A61K31/661 ,  A61K31/685 ,  A61K38/00 ,  A61K45/00 ,  A61P9/10 ,  A61P25/00

摘要： The present invention provides methods for treating alpha-synuclein-induced toxicity using phosphatidic acid to phosphoinositide biosynthesis pathway inhibitors, such as a nucleic acid molecule, a small molecule, or a nuclease, among others.